Teresa Mortera Blanco

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About me

Teresa Mortera-Blanco is an MEng, MSc, PhD, who works as a Senior Research
Specialist and Biobank Manager at the Center for Hematology and Regenerative
Medicine (HERM) in Eva Hellström-Lindberg laboratory.
She took her undergraduate studies at Bath University (UK) where she obtained
a Masters degree in Chemical Engineering and afterwards moved to Nottingham
University (UK) where she received a Masters in Science in Applied
Biomolecular Technology. She then took her PhD in Chemical Engineering from
Imperial College London (UK) and joined the group at the Karolinska
Institutet in 2012.

Research

Her current research is focused on the isolation and functional
characterisation of stem cells from low risk MDS and specialises in 3D
culture systems, multi-colour flow cytometry and leukemic stem cell
biology.

Articles

Article: BLOOD. 2024;143(11):953-966

Identification and surveillance of rare relapse-initiating stem cells during complete remission after transplantation.

Dimitriou M; Mortera-Blanco T; Tobiasson M; Mazzi S; Lehander M; Högstrand K; Karimi M; Walldin G; Jansson M; Vonlanthen S; Ljungman P; Langemeijer S; Yoshizato T; Hellström-Lindberg E; Woll PS; Jacobsen SEW
Article: CANCER RESEARCH. 2024;84(2):211-225

Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts.

Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Björklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellström-Lindberg E
Article: CLINICAL CANCER RESEARCH. 2023;29(20):4256-4267

Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts.

Todisco G; Creignou M; Bernard E; Björklund A-C; Moura PL; Tesi B; Mortera-Blanco T; Sander B; Jansson M; Walldin G; Barbosa I; Reinsbach SE; Hofman IJ; Nilsson C; Yoshizato T; Dimitriou M; Chang D; Olafsdottir S; Venckute Larsson S; Tobiasson M; Malcovati L; Woll P; Jacobsen SEW; Papaemmanuil E; Hellström-Lindberg E
Journal article: HEMASPHERE. 2023;7(Suppl):e22964a1

P713: EXPLORING CLONAL COMPETITION THROUGH 12‐YEAR FOLLOW‐UP OF AN MDS‐RS PATIENT WITH DUAL SF3B1 MUTATIONS

Moura P; Hofman I; Nannya Y; Aliouat A; Mortera‐Blanco T; Yoshizato T; Saiki R; Nakagawa M; Björklund A; Walldin G; Barbosa I; Jansson M; Grasso F; Creignou M; Elvarsdottir E; Woll P; Jacobsen SE; Ogawa S; Lindberg EH
Journal article: LEUKEMIA RESEARCH. 2023;128:107256

UNDERSTANDING CMML BIOLOGY BY INTEGRATIVE ANALYSIS OF EXOME SEQUENCING, RNA SEQUENCING, AND METHYLOME IN A LARGE PATIENT COHORT

Kynning MK; Nannya Y; Todisco G; Yoshizato T; Tesi B; Mortera-Blanco T; Bjorklund A-C; Bruck O; Ohyashiki K; Ishikawa T; Ochi Y; Haferlach T; Mustjoki S; Hellstrom-Lindberg E; Ogawa S; Ungerstedt J
Journal article: LEUKEMIA RESEARCH. 2023;128:107135

ACCELERATED RNA SPLICING DYNAMICS DURING ERYTHROID DIFFERENTIATION AMPLIFY MIS-SPLICING IN SF3B1-MUTANT MDS-RS

Moura P; Mortera-Blanco T; Hofman I; Todisco G; Kretzschmar W; Bjorklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Granados D; Barbosa I; Walldin G; Jansson M; Mead A; Lundin V; Dimitriou M; Yoshizato T; Woll P; Ogawa S; Sandberg R; Jacobsen SE; Hellstrom-Lindberg E
Journal article: LEUKEMIA RESEARCH. 2023;128:107119

EARLY TRANSFUSION PATTERNS PREDICT OUTCOMES INDEPENDENTLY OF IPSS-M SCORE IN MYELODYSPLASTIC SYNDROMES

Creignou M; Bernard E; Crowther M; Tranberg A; Todisco G; Moura P; Ejerblad E; Nilsson L; Garelius H; Antunovic P; Lorenz F; Rasmussen B; Walldin G; Mortera-Blanco T; Jansson M; Tobiasson M; Edgren G; Jadersten M; Papaemmanuil E; Hellstrom-Lindberg E
Article: BLOOD ADVANCES. 2022;6(10):2992-3005

Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs.

Asimomitis G; Deslauriers AG; Kotini AG; Bernard E; Esposito D; Olszewska M; Spyrou N; Arango Ossa J; Mortera-Blanco T; Koche R; Nannya Y; Malcovati L; Ogawa S; Cazzola M; Aaronson SA; Hellström-Lindberg E; Papaemmanuil E; Papapetrou EP
Article: NATURE CELL BIOLOGY. 2022;24(3):299-306

Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome.

Guzzi N; Muthukumar S; Cieśla M; Todisco G; Ngoc PCT; Madej M; Munita R; Fazio S; Ekström S; Mortera-Blanco T; Jansson M; Nannya Y; Cazzola M; Ogawa S; Malcovati L; Hellström-Lindberg E; Dimitriou M; Bellodi C
Journal article: BLOOD. 2021;138:146

Integrative Analysis of Primary SF3B1 ^mt Ring Sideroblasts Provides Fundamental Insights into MDS-RS Pathogenesis and Dyserythropoiesis

Moura PL; Mortera-Blanco T; Hofman IJF; Todisco G; Kretzschmar WW; Barbosa I; Bjorklund A-C; Walldin G; Jansson M; Yoshizato T; Woll PS; Jacobsen SEW; Lindberg EH
Journal article: LEUKEMIA RESEARCH. 2021;108:106679.9

O13 Topic: AS01-Diagnosis/AS01c-Molecular aberrations (cytogenetic, genetic, gene expression) WHOLE TRANSCRIPTOME ANALYSIS IDENTIFIES DISTINCT GENE EXPRESSION PROFILES BETWEEN SF3B1MUT AND SF3B1WT MYELODYSPLASTIC SYNDROME WITH RING SIDEROBLASTS

Todisco G; Creignou M; Bernard E; Björklund A-C; Moura P; Jansson M; Barbosa I; Chang D; Venckute S; Walldin G; Tesi B; Mortera-Blanco T; Papaemmanuil E; Hellström-Lindberg E
Article: LEUKEMIA. 2020;34(1):271-282

A three-dimensional in vitro model of erythropoiesis recapitulates erythroid failure in myelodysplastic syndromes.

Elvarsdóttir EM; Mortera-Blanco T; Dimitriou M; Bouderlique T; Jansson M; Hofman IJF; Conte S; Karimi M; Sander B; Douagi I; Woll PS; Hellström-Lindberg E
Article: BLOOD. 2017;130(7):881-890

SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells.

Mortera-Blanco T; Dimitriou M; Woll PS; Karimi M; Elvarsdottir E; Conte S; Tobiasson M; Jansson M; Douagi I; Moarii M; Saft L; Papaemmanuil E; Jacobsen SEW; Hellström-Lindberg E
Article: ONCOTARGET. 2016;7(45):72685-72698

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.

Dimitriou M; Woll PS; Mortera-Blanco T; Karimi M; Wedge DC; Doolittle H; Douagi I; Papaemmanuil E; Jacobsen SEW; Hellström-Lindberg E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;171(4):478-490

Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts.

Conte S; Katayama S; Vesterlund L; Karimi M; Dimitriou M; Jansson M; Mortera-Blanco T; Unneberg P; Papaemmanuil E; Sander B; Skoog T; Campbell P; Walfridsson J; Kere J; Hellström-Lindberg E
Article: CANCER CELL. 2014;25(6):794-808

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Woll PS; Kjällquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Göhring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW
Journal article: BLOOD. 2013;122(21):4195

Diverse Genetic Lesions In Myelodysplastic Syndromes Originate Exclusively In Rare MDS Stem Cells

Woll P; Kjällquist U; Chowdhury O; Erlandsson R; Doolittle H; Ngara M; Anderson K; Giannoulatou E; Taylor S; Deng Q; Mead AJ; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Josefsen D; Kvalheim G; Göhring G; Schlegelberger B; Tobiasson M; Holm MS; Hokland P; Fenaux P; Nerlov C; Dybedal I; Nilsson L; Sandberg R; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW
Article: LEUKEMIA. 2013;27(4):889-896

The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts.

Nikpour M; Scharenberg C; Liu A; Conte S; Karimi M; Mortera-Blanco T; Giai V; Fernandez-Mercado M; Papaemmanuil E; Högstrand K; Jansson M; Vedin I; Wainscoat JS; Campbell P; Cazzola M; Boultwood J; Grandien A; Hellström-Lindberg E
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2012;(62):3654

Ex vivo mimicry of normal and abnormal human hematopoiesis.

Mortera-Blanco T; Rende M; Macedo H; Farah S; Bismarck A; Mantalaris A; Panoskaltsis N
Article: BIOMATERIALS. 2011;32(35):9263-9270

Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds.

Mortera-Blanco T; Mantalaris A; Bismarck A; Aqel N; Panoskaltsis N
Article: BIOMATERIALS. 2010;31(8):2243-2251

The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia.

Blanco TM; Mantalaris A; Bismarck A; Panoskaltsis N
Journal article: BLOOD. 2009;114(22):503

Long-Term in Vitro Cytokine-Free and Serum-Free Culture of Human Cord Blood Mononuclear Cells in a Three-Dimensional Scaffold.

Mortera-Blanco T; Mantalaris A; Bismarck A; Panoskaltsis N
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Preprint: BIORXIV. 2023

Erythroid differentiation intensifies RNA mis-splicing in SF3B1-mutant myelodysplastic syndromes with ring sideroblasts

Moura PL; Mortera-Blanco T; Hofman IJF; Todisco G; Kretzschmar WW; Björklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Granados DC; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellström-Lindberg E
Conference publication: BLOOD. 2022;140:6898-6899

Long-Term Clonal Inversion in an MDS-RS Case with Dual SF3B1 Mutations

Moura PL; Hofman IJF; Nannya Y; Aliouat A; Mortera-Blanco T; Yoshizato T; Saiki R; Nakagawa MM; Bjorklund A-C; Walldin G; Barbosa I; Jansson M; Grasso F; Creignou M; Elvarsdottir EM; Woll PS; Jacobsen SEW; Ogawa S; Hellstrom-Lindberg E
Meeting abstract: BLOOD. 2022;140:6968-6970

Transfusion Patterns during Early Follow-up Predict Overall Survival Independently of IPSS-M in Patients with Myelodysplastic Syndromes

Creignou M; Bernard E; Crowther M; Tranberg A; Ejerblad E; Nilsson L; Garelius H; Antunovic P; Rasmussen BEH; Lorenz F; Todisco G; Walldin G; Mortera-Blanco T; Jansson M; Tobiasson M; Edgren G; Jadersten M; Papaemmanuil E; Hellstrom-Lindberg E
Letter: BLOOD ADVANCES. 2022;6(16):4705-4709

The extent of residual WT HSPCs is associated with the degree of anemia in patients with SF3B1-mutated MDS-RS.

Hofman IJF; Mortera-Blanco T; Moura PL; Vestlund J; Larsson SV; Elvarsdottir EM; Walldin G; Tobiasson M; Sander B; Dimitriou M; Jacobsen S-EW; Woll PS; Jädersten M; Hellström-Lindberg E
Meeting abstract: BLOOD. 2021;138:147

Isogenic MDS-RS Patient-Derived iPSCs Define the Mis-Spliced Transcript Repertoire and Chromatin Landscape of SF3B1-Mutant Hematopoietic Stem/Progenitor Cells

Simomitis GA; Deslauriers AG; Kotini AG; Bernard E; Esposito D; Olszewska M; Spyrou N; Ossa JA; Mortera-Blanco T; Koche R; Aaronson S; Hellstrom-Lindberg E; Papaemmanuil E; Papapetrou EP
Meeting abstract: BLOOD. 2021;138:3695

Whole Transcriptome Analysis Identifies Distinct Gene Expression Profiles between SF3B1mut and SF3B1 wt Myelodysplastic Syndrome with Ring Sideroblasts

Todisco G; Creignou M; Bernard E; Björklund A-C; Moura PL; Jansson M; Chang D; Venckute S; Walldin G; Malcovati L; Tesi B; Mortera-Blanco T; Barbosa I; Papaemmanuil E; Lindberg EH
Conference publication: LEUKEMIA RESEARCH. 2021;108:S10-S11

WHOLE TRANSCRIPTOME ANALYSIS IDENTIFIES DISTINCT GENE EXPRESSION PROFILES BETWEEN SF3B1MUT AND SF3B1WT MYELODYSPLASTIC SYNDROME WITH RING SIDEROBLASTS

Todisco G; Creignou M; Bernard E; Bjorklund A-C; Moura P; Jansson M; Barbosa I; Chang D; Venckute S; Walldin G; Tesi B; Mortera-Blanco T; Papaemmanuil E; Hellstrom-Lindberg E
Conference publication: BLOOD. 2019;134:2993

Identification of an Expanded Immature Cell Population in Human Bone Marrow during Erythroid Responses to ESA Treatment

Hofman IJF; Mortera-Blanco T; Larsson SV; Jacobsen SEW; Woll PS; Dimitriou M; Lindberg EH
Review: WORLD JOURNAL OF STEM CELLS. 2019;11(8):476-490

Bone marrow microenvironment: The guardian of leukemia stem cells.

Houshmand M; Blanco TM; Circosta P; Yazdi N; Kazemi A; Saglio G; Zarif MN
Conference publication: HAEMATOLOGICA. 2016;101:69

A CULTURE MODEL MIMICKING THE BM-NICHE ALLOWS FOR STUDYING THE DYSREGULATED ERYTHROPOIESIS OF SF3B1 MUTATED MYELODYSPLASTIC SYNDROME WITH RINGED SIDEROBLASTS

Elvarsdottir EM; Mortera-Blanco T; Dimitriou M; Conte S; Sander B; Jansson M; Douagi I; Jacobsen SE; Hellstrom-Lindberg E
Conference publication: HAEMATOLOGICA. 2016;101:159

SF3B1 MUTATIONS IN MDS-RS ARISE IN MULTIPOTENT HEMOPOETIC STEM CELLS

Mortera-Blanco T; Dimitriou M; Woll PS; Elvarsdottir E; Karimi M; Conte S; Jansson M; Douagi I; Papaemmanuil E; Jacobsen SE; Hellstrom-Lindberg E
Book chapter: COMPREHENSIVE BIOTECHNOLOGY. 2016;p. 225-235

5.17 Tissue Engineering of Normal and Abnormal Bone Marrow☆

Mortera-Blanco T; Rende M; Panoskaltsis N; Mantalaris A
Conference publication: LEUKEMIA RESEARCH. 2015;39:S36

CHARACTERIZATION OF THE HEMATOPOIETIC STEM AND PROGENITOR CELL HIERARCHY IN MYELODYSPLASTIC SYNDROMES PATIENTS WITH MONOSOMY 7 AS THE SOLE CYTOGENETIC ABNORMALITY

Dimitriou M; Mortera-Blanco T; Woll PS; Karimi M; Doolittle H; Wedge DC; Papaemmanuil E; Jacobsen SE; Hellstrom-Lindberg E
Corrigendum: CANCER CELL. 2015;27(4):603-605

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)

Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Conference publication: BLOOD. 2014;124(21):3490

Characterization of the Hematopoietic Stem and Progenitor Cell Hierarchy in Myelodysplastic Syndromes Patients with Monosomy 7 As the Sole Cytogenetic Abnormality

Dimitriou M; Mortera-Blanco T; Woll PS; Karimi M; Doolittle H; Jacobsen SEW; Hellstrom-Lindberg E
Corrigendum: CANCER CELL. 2014;25(6):861

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)

Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Meeting abstract: BLOOD. 2013;122(21):2408

Erythropoiesis In SF3B1 Mutated RARS Is Disrupted During Terminal Erythroid Maturation

Conte S; Vesterlund L; Katayama S; Karimi M; Papaemmanuil E; Jansson M; Mortera-Blanco T; Dimitriou M; Sander B; Skoog T; Campbell PJ; Kere J; Unneberg P; Hellstroem-Lindberg E
Meeting abstract: LEUKEMIA RESEARCH. 2013;37:S24-S25

Aberrant splicing during erythroid differentiation in SF3B1 mutated sideroblastic anemia

Conte S; Vesterlund L; Katayama S; Karimi M; Unneberg P; Papaemmanuil E; Jansson M; Mortera-Blanco T; Dimitriou M; Sander B; Skoog T; Campbell P; Kere J; Hellstrom-Lindberg E
Conference publication: HAEMATOLOGICA. 2013;98:73-74

ABERRANT SPLICING DURING ERYTHROID DIFFERENTIATION IN SF3B1 MUTATED SIDEROBLASTIC

Conte S; Vesterlund L; Katayama S; Karimi M; Unneberg P; Papaemmanuil E; Jansson M; Mortera-Blanco T; Dimitriou M; Sander B; Skoog T; Campbells P; Kere J; Hellstrom-Lindberg E
Meeting abstract: BLOOD. 2012;120(21):276

Physiologic Erythropoiesis with Enhanced Globin Switching and Endogenous Cytokine Production in a Long-Term Serum-free in Vitro human Bone Marrow Biomimicry

Rende M; Fauzi I; Mortera-Blanco T; da Costa Medeiros JM; Mantalaris A; Panoskaltsis N
Book chapter: COMPREHENSIVE BIOTECHNOLOGY. 2011;p. 331-340

5.26 Tissue Engineering of Normal and Abnormal Bone Marrow

Mortera-Blanco T; Panoskaltsis N; Mantalaris A
Review: JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2009;6(32):209-232

Stem cell bioprocessing: fundamentals and principles.

Placzek MR; Chung I-M; Macedo HM; Ismail S; Mortera Blanco T; Lim M; Cha JM; Fauzi I; Kang Y; Yeo DCL; Ma CYJ; Polak JM; Panoskaltsis N; Mantalaris A
Conference publication: BLOOD. 2009;114(22):208

Long-Term in Vitro Cytokine-Free and Serum-Free Culture of Human Cord Blood Mononuclear Cells in a Three-Dimensional Scaffold

Mortera-Blanco T; Mantalaris A; Bismarck A; Panoskaltsis N
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