About me
Education
M.Sci Stockholm University 1988, M.Med.Sc Karolinska Institutet 1989
Ph.D Karolinska Institutet 1999, Associate Professor, Karolinska Institutet 2007
Research description
Periodontitis is a chronic inflammatory disease in which bacterial products, host response, genetic and environmental factors are involved. It is generally accepted that the bacterial products activate host immunoinflammatory responses and subsequently the production of inflammatory mediators, prostaglandins and proteolytic enzymes which, directly or indirectly, contribute to the destruction of the periodontal tissues. However, neither the precise molecular mechanism(s) nor the regulatory genes underlying periodontitis are fully understood. During past decades, reciprocal effects of periodontal disease have been considered as factors potentially affecting the progression of other chronic inflammatory diseases such as cardiovascular diseases, diabetes mellitus, obesity, and rheumatoid arthritis. The underlying pathological mechanisms of periodontitis and rheumatoid arthritis are strikingly similar although the link, strength and temporality of the association is still not understood.
Objectives of our research are:
- to identify predictive and diagnostic biomarkers for periodontitis - to develop anti-inflammatory agents targeting the enzyme prostaglandin E synthases for chronic inflammation and bone destruction - to investigate the relationship between periodontitis/periodontal pathogens and associated diseases such as rheumatoid arthritis and diabetes - to study the interactions between oral microbiome and carcinogenesis
Group members
Tülay Yucel-Lindberg – Associate professor; Carina Fie – PhD student; Anders Lindunger – PhD student; Carl Lundgren– PhD student; Kaja Eriksson – associated; Anna Lundmark – associated; Anna Kats – associated; Mehrad Mohammadi – KI’s summer research school; Elizabeth Stenwall – KI’s summer research school
Research grants
The Swedish Research Council, Vetenskapsrådet; The Patent Revenue Fund for Research in Preventive Odontology, Patentmedelsfonden; Stockholm County Council, KI/SLL for odontological research; Stockholm County Council, ALF; Reumatikerförbundet
Dissertations
Tove Båge - Prostaglandin E synthases in periodontitis-affected gingival tissue and in gingival fibroblasts
Anna Kats - Expression of prostaglandin E synthase-1 in periodontitis : in vivo and in vitro studies
Haleh Davanian - Gene expression profiling in periodontitis
Kaja Eriksson - Studies on the relationship between periodontitis and rheumatoid arthritis
Anna Lundmark - Transcriptomic and taxonomic profiling of periodontitis by massively parallel sequencing