Ulf Eriksson

About me
Publications
Public outreach and news

About me

Ulf Eriksson is a Professor of Vascular Biochemistry, with a special focus on
growth factor-regulated endothelial cell functions, at the Department of
Medical Biochemistry and Biophysics.

Articles

Article: JOURNAL OF HEPATOLOGY. 2023;78(5):901-913

Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue.

Falkevall A; Mehlem A; Folestad E; Ning FC; Osorio-Conles Ó; Radmann R; de Hollanda A; Wright SD; Scotney P; Nash A; Eriksson U
Article: BLOOD. 2022;140(4):388-400

Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCβ phosphorylation of occludin.

Goncalves A; Su EJ; Muthusamy A; Zeitelhofer M; Torrente D; Nilsson I; Protzmann J; Fredriksson L; Eriksson U; Antonetti DA; Lawrence DA
Article: SCIENTIFIC REPORTS. 2020;10(1):22383

Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier.

Zeitelhofer M; Adzemovic MZ; Moessinger C; Stefanitsch C; Strell C; Muhl L; Brundin L; Fredriksson L; Olsson T; Eriksson U; Nilsson I
Article: LUNG CANCER. 2020;150:1-8

Analysis of angiogenic and stromal biomarkers in a large malignant mesothelioma cohort.

Chia PL; Russell P; Asadi K; Thapa B; Gebski V; Murone C; Walkiewicz M; Eriksson U; Scott AM; John T
Article: EMBO REPORTS. 2020;21(7):e49343

VEGF-B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content.

Moessinger C; Nilsson I; Muhl L; Zeitelhofer M; Heller Sahlgren B; Skogsberg J; Eriksson U
Article: SCIENTIFIC REPORTS. 2020;10(1):923

VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake.

Ning FC; Jensen N; Mi J; Lindström W; Balan M; Muhl L; Eriksson U; Nilsson I; Nyqvist D
Article: SCIENTIFIC REPORTS. 2019;9(1):14636

Noninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours.

Balan M; Trusohamn M; Ning FC; Jacob S; Pietras K; Eriksson U; Berggren P-O; Nyqvist D
Article: KIDNEY INTERNATIONAL. 2019;95(5):1103-1119

Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension.

van Roeyen CRC; Martin IV; Drescher A; Schuett KA; Hermert D; Raffetseder U; Otten S; Buhl EM; Braun GS; Kuppe C; Liehn E; Boor P; Weiskirchen R; Eriksson U; Gross O; Eitner F; Floege J; Ostendorf T
Article: NEURORADIOLOGY. 2018;60(7):759-768

Transcriptomic analysis of the harvested endothelial cells in a swine model of mechanical thrombectomy.

Jaff N; Grankvist R; Muhl L; Chireh A; Sandell M; Jonsson S; Arnberg F; Eriksson U; Holmin S
Article: NATURE MEDICINE. 2018;24(4):463-473

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Roswall P; Bocci M; Bartoschek M; Li H; Kristiansen G; Jansson S; Lehn S; Sjölund J; Reid S; Larsson C; Eriksson P; Anderberg C; Cortez E; Saal LH; Orsmark-Pietras C; Cordero E; Haller BK; Häkkinen J; Burvenich IJG; Lim E; Orimo A; Höglund M; Rydén L; Moch H; Scott AM; Eriksson U; Pietras K
Article: PLOS ONE. 2018;13(7):e0200649

Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CChum mice.

Zeitelhofer M; Li H; Adzemovic MZ; Nilsson I; Muhl L; Scott AM; Eriksson U
Article: PLOS ONE. 2018;13(7):e0201089

Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo.

Li H; Zeitelhofer M; Nilsson I; Liu X; Allan L; Gloria B; Perani A; Murone C; Catimel B; Neville AM; Scott FE; Scott AM; Eriksson U
Article: ACTA NEUROPATHOLOGICA. 2017;134(4):585-604

Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.

Su EJ; Cao C; Fredriksson L; Nilsson I; Stefanitsch C; Stevenson TK; Zhao J; Ragsdale M; Sun Y-Y; Yepes M; Kuan C-Y; Eriksson U; Strickland DK; Lawrence DA; Zhang L
Article: JOURNAL OF CELL SCIENCE. 2017;130(8):1365-1378

Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling.

Muhl L; Folestad EB; Gladh H; Wang Y; Moessinger C; Jakobsson L; Eriksson U
Article: CELL METABOLISM. 2017;25(3):713-726

Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.

Falkevall A; Mehlem A; Palombo I; Heller Sahlgren B; Ebarasi L; He L; Ytterberg AJ; Olauson H; Axelsson J; Sundelin B; Patrakka J; Scotney P; Nash A; Eriksson U
Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(3):273-283

Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis.

Wahlgren N; Thorén M; Höjeberg B; Käll T-B; Laska A-C; Sjöstrand C; Höijer J; Almqvist H; Holmin S; Lilja A; Fredriksson L; Lawrence D; Eriksson U; Ahmed N
Article: CELL AND TISSUE RESEARCH. 2016;365(1):51-63

Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney.

Muhl L; Moessinger C; Adzemovic MZ; Dijkstra MH; Nilsson I; Zeitelhofer M; Hagberg CE; Huusko J; Falkevall A; Ylä-Herttuala S; Eriksson U
Article: BIOLOGY OPEN. 2016;5(4):461-474

A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex.

Andrae J; Gouveia L; Gallini R; He L; Fredriksson L; Nilsson I; Johansson BR; Eriksson U; Betsholtz C
Article: KIDNEY INTERNATIONAL. 2016;89(4):848-861

The role of PDGF-D in healthy and fibrotic kidneys.

Buhl EM; Djudjaj S; Babickova J; Klinkhammer BM; Folestad E; Borkham-Kamphorst E; Weiskirchen R; Hudkins K; Alpers CE; Eriksson U; Floege J; Boor P
Article: DIABETES. 2016;65(4):861-873

PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B.

Mehlem A; Palombo I; Wang X; Hagberg CE; Eriksson U; Falkevall A
Article: ACTA NEUROPATHOLOGICA. 2016;131(3):453-464

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.

Lewandowski SA; Nilsson I; Fredriksson L; Lönnerberg P; Muhl L; Zeitelhofer M; Adzemovic MZ; Nichterwitz S; Lawrence DA; Hedlund E; Eriksson U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(7):E864-E873

Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD.

Cortez E; Gladh H; Braun S; Bocci M; Cordero E; Björkström NK; Miyazaki H; Michael IP; Eriksson U; Folestad E; Pietras K
Article: PLOS ONE. 2016;11(3):e0152276

Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype.

Gladh H; Folestad EB; Muhl L; Ehnman M; Tannenberg P; Lawrence A-L; Betsholtz C; Eriksson U
Article: JOURNAL OF NEUROTRAUMA. 2015;32(21):1645-1657

Delayed Imatinib Treatment for Acute Spinal Cord Injury: Functional Recovery and Serum Biomarkers.

Kjell J; Finn A; Hao J; Wellfelt K; Josephson A; Svensson CI; Wiesenfeld-Hallin Z; Eriksson U; Abrams M; Olson L
Article: AMERICAN JOURNAL OF PATHOLOGY. 2015;185(8):2132-2142

Role of platelet-derived growth factor-CC in capillary rarefaction in renal fibrosis.

Boor P; Bábíčková J; Steegh F; Hautvast P; Martin IV; Djudjaj S; Nakagawa T; Ehling J; Gremse F; Bücher E; Eriksson U; van Roeyen CRC; Eitner F; Lammers T; Floege J; Peutz-Kootstra CJ; Ostendorf T
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2015;308(7):L658-L671

Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma.

Johnson JR; Folestad E; Rowley JE; Noll EM; Walker SA; Lloyd CM; Rankin SM; Pietras K; Eriksson U; Fuxe J
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2015;9:385

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury.

Su EJ; Fredriksson L; Kanzawa M; Moore S; Folestad E; Stevenson TK; Nilsson I; Sashindranath M; Schielke GP; Warnock M; Ragsdale M; Mann K; Lawrence A-LE; Medcalf RL; Eriksson U; Murphy GG; Lawrence DA
Article: CARDIOVASCULAR RESEARCH. 2013;99(4):716-723

The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models.

Heinonen SE; Kivelä AM; Huusko J; Dijkstra MH; Gurzeler E; Mäkinen PI; Leppänen P; Olkkonen VM; Eriksson U; Jauhiainen M; Ylä-Herttuala S
Article: NATURE PROTOCOLS. 2013;8(6):1149-1154

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease.

Mehlem A; Hagberg CE; Muhl L; Eriksson U; Falkevall A
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2013;28(4):889-900

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts.

Seikrit C; Henkel C; van Roeyen CRC; Bokemeyer D; Eitner F; Martin IV; Boor P; Knüchel R; Meyer HE; Müller-Newen G; Eriksson U; Floege J; Ostendorf T
Article: CANCER RESEARCH. 2013;73(7):2139-2149

Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments.

Ehnman M; Missiaglia E; Folestad E; Selfe J; Strell C; Thway K; Brodin B; Pietras K; Shipley J; Östman A; Eriksson U
Article: PLOS ONE. 2013;8(2):e56586

Imatinib ameliorates neuroinflammation in a rat model of multiple sclerosis by enhancing blood-brain barrier integrity and by modulating the peripheral immune response.

Adzemovic MV; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(1):107-117

Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis.

Martin IV; Borkham-Kamphorst E; Zok S; van Roeyen CRC; Eriksson U; Boor P; Hittatiya K; Fischer H-P; Wasmuth HE; Weiskirchen R; Eitner F; Floege J; Ostendorf T
Article: NATURE. 2012;490(7420):426-430

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes.

Hagberg CE; Mehlem A; Falkevall A; Muhl L; Fam BC; Ortsäter H; Scotney P; Nyqvist D; Samén E; Lu L; Stone-Elander S; Proietto J; Andrikopoulos S; Sjöholm A; Nash A; Eriksson U
Article: AMERICAN JOURNAL OF PATHOLOGY. 2012;180(3):1136-1144

Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities.

Fredriksson L; Nilsson I; Su EJ; Andrae J; Ding H; Betsholtz C; Eriksson U; Lawrence DA
Article: PLOS ONE. 2012;7(6):e38760

Imatinib enhances functional outcome after spinal cord injury.

Abrams MB; Nilsson I; Lewandowski SA; Kjell J; Codeluppi S; Olson L; Eriksson U
Article: PLOS ONE. 2010;5(11):e14109

Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis.

Albrecht I; Kopfstein L; Strittmatter K; Schomber T; Falkevall A; Hagberg CE; Lorentz P; Jeltsch M; Alitalo K; Eriksson U; Christofori G; Pietras K
Article: JOURNAL OF NEUROSCIENCE. 2010;30(45):15052-15066

Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1.

Ruiz de Almodovar C; Coulon C; Salin PA; Knevels E; Chounlamountri N; Poesen K; Hermans K; Lambrechts D; Van Geyte K; Dhondt J; Dresselaers T; Renaud J; Aragones J; Zacchigna S; Geudens I; Gall D; Stroobants S; Mutin M; Dassonville K; Storkebaum E; Jordan BF; Eriksson U; Moons L; D'Hooge R; Haigh JJ; Belin M-F; Schiffmann S; Van Hecke P; Gallez B; Vinckier S; Chédotal A; Honnorat J; Thomasset N; Carmeliet P; Meissirel C
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(1):58-69

PDGF-C mediates glomerular capillary repair.

Boor P; van Roeyen CRC; Kunter U; Villa L; Bücher E; Hohenstein B; Hugo CPM; Eriksson U; Satchell SC; Mathieson PW; Eitner F; Floege J; Ostendorf T
Article: NATURE. 2010;464(7290):917-921

Vascular endothelial growth factor B controls endothelial fatty acid uptake.

Hagberg CE; Falkevall A; Wang X; Larsson E; Huusko J; Nilsson I; van Meeteren LA; Samen E; Lu L; Vanwildemeersch M; Klar J; Genove G; Pietras K; Stone-Elander S; Claesson-Welsh L; Ylä-Herttuala S; Lindahl P; Eriksson U
Article: CARDIOVASCULAR RESEARCH. 2010;86(1):122-130

The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice.

Huusko J; Merentie M; Dijkstra MH; Ryhänen M-M; Karvinen H; Rissanen TT; Vanwildemeersch M; Hedman M; Lipponen J; Heinonen SE; Eriksson U; Shibuya M; Ylä-Herttuala S
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2009;39(4):320-327

PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries.

Karvinen H; Rutanen J; Leppänen O; Lach R; Levonen A-L; Eriksson U; Ylä-Herttuala S
Article: CIRCULATION. 2009;119(6):845-856

Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms.

Lähteenvuo JE; Lähteenvuo MT; Kivelä A; Rosenlew C; Falkevall A; Klar J; Heikura T; Rissanen TT; Vähäkangas E; Korpisalo P; Enholm B; Carmeliet P; Alitalo K; Eriksson U; Ylä-Herttuala S
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2009;296(2):H442-H452

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.

Thomas JA; Deaton RA; Hastings NE; Shang Y; Moehle CW; Eriksson U; Topouzis S; Wamhoff BR; Blackman BR; Owens GK
Article: ONCOGENE. 2009;28(4):534-544

The uPA/uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growth.

Ehnman M; Li H; Fredriksson L; Pietras K; Eriksson U
Article: CANCER RESEARCH. 2009;69(1):369-378

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts.

Anderberg C; Li H; Fredriksson L; Andrae J; Betsholtz C; Li X; Eriksson U; Pietras K
Article: CIRCULATION RESEARCH. 2008;103(10):1092-1U71

Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.

Korpisalo P; Karvinen H; Rissanen TT; Kilpijoki J; Marjomäki V; Baluk P; McDonald DM; Cao Y; Eriksson U; Alitalo K; Ylä-Herttuala S
Article: JOURNAL OF NEUROSCIENCE. 2008;28(42):10451-10459

Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration.

Poesen K; Lambrechts D; Van Damme P; Dhondt J; Bender F; Frank N; Bogaert E; Claes B; Heylen L; Verheyen A; Raes K; Tjwa M; Eriksson U; Shibuya M; Nuydens R; Van Den Bosch L; Meert T; D'Hooge R; Sendtner M; Robberecht W; Carmeliet P
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2008;28(9):1614-1620

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

Li X; Tjwa M; Van Hove I; Enholm B; Neven E; Paavonen K; Jeltsch M; Juan TD; Sievers RE; Chorianopoulos E; Wada H; Vanwildemeersch M; Noel A; Foidart J-M; Springer ML; von Degenfeld G; Dewerchin M; Blau HM; Alitalo K; Eriksson U; Carmeliet P; Moons L
Article: NATURE MEDICINE. 2008;14(7):731-737

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.

Su EJ; Fredriksson L; Geyer M; Folestad E; Cale J; Andrae J; Gao Y; Pietras K; Mann K; Yepes M; Strickland DK; Betsholtz C; Eriksson U; Lawrence DA
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2008;19(2):281-289

PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis.

Eitner F; Bücher E; van Roeyen C; Kunter U; Rong S; Seikrit C; Villa L; Boor P; Fredriksson L; Bäckström G; Eriksson U; Ostman A; Floege J; Ostendorf T
Article: FASEB JOURNAL. 2007;21(13):3696-3704

Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes.

Ost A; Danielsson A; Lidén M; Eriksson U; Nystrom FH; Strålfors P
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(11):3188-3197

Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice.

Tirziu D; Chorianopoulos E; Moodie KL; Palac RT; Zhuang ZW; Tjwa M; Roncal C; Eriksson U; Fu Q; Elfenbein A; Hall AE; Carmeliet P; Moons L; Simons M
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2006;63(10):1205-1213

Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.

Shafqat N; Shafqat J; Eissner G; Marschall H-U; Tryggvason K; Eriksson U; Gabrielli F; Lardy H; Jörnvall H; Oppermann U
Article: EXPERIMENTAL CELL RESEARCH. 2005;311(2):205-217

The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function.

Lidén M; Tryggvason K; Eriksson U
Article: CIRCULATION RESEARCH. 2005;97(10):1036-1045

Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice.

Pontén A; Folestad EB; Pietras K; Eriksson U
Article: EXPERIMENTAL CELL RESEARCH. 2005;310(2):401-408

Development of a versatile reporter assay for studies of retinol uptake and metabolism in vivo.

Lidén M; Eriksson U
Article: CIRCULATION. 2005;112(9):1347-1352

Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice.

Leppänen P; Koota S; Kholová I; Koponen J; Fieber C; Eriksson U; Alitalo K; Ylä-Herttuala S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):26856-26862

Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator.

Fredriksson L; Ehnman M; Fieber C; Eriksson U
Article: JOURNAL OF CLINICAL INVESTIGATION. 2005;115(1):118-127

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.

Li X; Tjwa M; Moons L; Fons P; Noel A; Ny A; Zhou JM; Lennartsson J; Li H; Luttun A; Pontén A; Devy L; Bouché A; Oh H; Manderveld A; Blacher S; Communi D; Savi P; Bono F; Dewerchin M; Foidart J-M; Autiero M; Herbert J-M; Collen D; Heldin C-H; Eriksson U; Carmeliet P
Article: BLOOD. 2004;104(10):3198-3204

PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.

Uutela M; Wirzenius M; Paavonen K; Rajantie I; He Y; Karpanen T; Lohela M; Wiig H; Salven P; Pajusola K; Eriksson U; Alitalo K
Article: EMBO JOURNAL. 2004;23(19):3793-3802

Tissue plasminogen activator is a potent activator of PDGF-CC.

Fredriksson L; Li H; Fieber C; Li X; Eriksson U
Article: CANCER RESEARCH. 2004;64(8):2725-2733

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.

Furuhashi M; Sjöblom T; Abramsson A; Ellingsen J; Micke P; Li H; Bergsten-Folestad E; Eriksson U; Heuchel R; Betsholtz C; Heldin C-H; Ostman A
Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(2):673-682

Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy.

Pontén A; Li X; Thorén P; Aase K; Sjöblom T; Ostman A; Eriksson U
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14(5):1145-1153

PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases.

Eitner F; Ostendorf T; Kretzler M; Cohen CD; Eriksson U; Gröne H-J; Floege J; ERCB-Consortium
Article: EXPERIMENTAL CELL RESEARCH. 2003;285(2):286-298

Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro.

Tille J-C; Wang X; Lipson KE; McMahon G; Ferrara N; Zhu Z; Hicklin DJ; Sleeman JP; Eriksson U; Alitalo K; Pepper MS
Article: ONCOGENE. 2003;22(10):1501-1510

PDGF-D is a potent transforming and angiogenic growth factor.

Li H; Fredriksson L; Li X; Eriksson U
Article: FASEB JOURNAL. 2002;16(12):1575-1583

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors.

Cao R; Bråkenhielm E; Li X; Pietras K; Widenfalk J; Ostman A; Eriksson U; Cao Y
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2002;13(4):910-917

Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney.

Eitner F; Ostendorf T; Van Roeyen C; Kitahara M; Li X; Aase K; Gröne H-J; Eriksson U; Floege J
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2002;398(2):284-290

New members of the platelet-derived growth factor family of mitogens.

Heldin C-H; Eriksson U; Ostman A
Article: MECHANISMS OF DEVELOPMENT. 2002;110(1-2):187-191

Expression analysis of PDGF-C in adult and developing mouse tissues.

Aase K; Abramsson A; Karlsson L; Betsholtz C; Eriksson U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(52):49251-49257

Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus.

Lidén M; Romert A; Tryggvason K; Persson B; Eriksson U
Article: MECHANISMS OF DEVELOPMENT. 2001;109(1):69-77

The Drosophila VEGF receptor homolog is expressed in hemocytes.

Heino TI; Kärpänen T; Wahlström G; Pulkkinen M; Eriksson U; Alitalo K; Roos C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;286(2):336-342

Increased retinoid signaling in vascular smooth muscle cells by proinflammatory cytokines.

Gidlöf AC; Romert A; Olsson A; Törmä H; Eriksson U; Sirsjö A
Article: CIRCULATION. 2001;104(3):358-364

Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect.

Aase K; von Euler G; Li X; Pontén A; Thorén P; Cao R; Cao Y; Olofsson B; Gebre-Medhin S; Pekny M; Alitalo K; Betsholtz C; Eriksson U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(22):19253-19258

Biosynthesis of 9-cis-retinoic acid in vivo. The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases.

Tryggvason K; Romert A; Eriksson U
Article: CIRCULATION. 2001;103(18):2242-2247

Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes.

Uutela M; Laurén J; Bergsten E; Li X; Horelli-Kuitunen N; Eriksson U; Alitalo K
Article: FASEB JOURNAL. 2001;15(7):1221-1223

Induction of CD36 by all-trans retinoic acid: retinoic acid receptor signaling in the pathogenesis of atherosclerosis.

Wuttge DM; Romert A; Eriksson U; Törmä H; Hansson GK; Sirsjö A
Article: NATURE CELL BIOLOGY. 2001;3(5):512-516

PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.

Bergsten E; Uutela M; Li X; Pietras K; Ostman A; Heldin CH; Alitalo K; Eriksson U
Article: NATURE MEDICINE. 2001;7(5):575-583

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

Carmeliet P; Moons L; Luttun A; Vincenti V; Compernolle V; De Mol M; Wu Y; Bono F; Devy L; Beck H; Scholz D; Acker T; DiPalma T; Dewerchin M; Noel A; Stalmans I; Barra A; Blacher S; VandenDriessche T; Ponten A; Eriksson U; Plate KH; Foidart JM; Schaper W; Charnock-Jones DS; Hicklin DJ; Herbert JM; Collen D; Persico MG
Article: JOURNAL OF CELL BIOLOGY. 2001;153(3):543-553

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.

Hellström M; Gerhardt H; Kalén M; Li X; Eriksson U; Wolburg H; Betsholtz C
Article: GROWTH FACTORS. 2001;19(1):49-59

Isoform-specific expression of VEGF-B in normal tissues and tumors.

Li X; Aase K; Li H; von Euler G; Eriksson U
Article: NATURE CELL BIOLOGY. 2000;2(5):302-309

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

Li X; Pontén A; Aase K; Karlsson L; Abramsson A; Uutela M; Bäckström G; Hellström M; Boström H; Li H; Soriano P; Betsholtz C; Heldin CH; Alitalo K; Ostman A; Eriksson U
Article: EXPERIMENTAL CELL RESEARCH. 2000;256(1):338-345

Gene structure, expression analysis, and membrane topology of RDH4.

Romert A; Tuvendal P; Tryggvason K; Dencker L; Eriksson U
Article: CIRCULATION RESEARCH. 1999;85(11):992-999

Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia.

Lymboussaki A; Olofsson B; Eriksson U; Alitalo K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(30):21217-21222

Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.

Makinen T; Olofsson B; Karpanen T; Hellman U; Soker S; Klagsbrun M; Eriksson U; Alitalo K
Article: PLACENTA. 1999;20(5-6):459-465

Retinoid binding proteins-expression patterns in the human placenta.

Johansson S; Gustafson AL; Donovan M; Eriksson U; Dencker L
Article: NATURE GENETICS. 1999;22(2):188-191

Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus.

Yamamoto H; Simon A; Eriksson U; Harris E; Berson EL; Dryja TP
Article: DEVELOPMENTAL DYNAMICS. 1999;215(1):12-25

Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature.

Aase K; Lymboussaki A; Kaipainen A; Olofsson B; Alitalo K; Eriksson U
Article: DEVELOPMENTAL BRAIN RESEARCH. 1999;114(1):121-126

CRBP I and CRABP I localisation during olfactory nerve development.

Gustafson AL; Eriksson U; Dencker L
Article: BIOCHEMICAL JOURNAL. 1999;338 ( Pt 1)(Pt 1):23-27

Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.

Wang J; Chai X; Eriksson U; Napoli JL
Article: JOURNAL OF CELL SCIENCE. 1999;112 ( Pt 4):549-558

Intracellular localization and membrane topology of 11-cis retinol dehydrogenase in the retinal pigment epithelium suggest a compartmentalized synthesis of 11-cis retinaldehyde.

Simon A; Romert A; Gustafson AL; McCaffery JM; Eriksson U
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(2):407-416

Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid.

Zetterström RH; Lindqvist E; Mata de Urquiza A; Tomac A; Eriksson U; Perlmann T; Olson L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(20):11709-11714

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells.

Olofsson B; Korpelainen E; Pepper MS; Mandriota SJ; Aase K; Kumar V; Gunji Y; Jeltsch MM; Shibuya M; Alitalo K; Eriksson U
Article: AMERICAN JOURNAL OF PATHOLOGY. 1998;153(1):103-108

Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors.

Salven P; Lymboussaki A; Heikkilä P; Jääskela-Saari H; Enholm B; Aase K; von Euler G; Eriksson U; Alitalo K; Joensuu H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(8):4404-4409

The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid.

Romert A; Tuvendal P; Simon A; Dencker L; Eriksson U
Article: PROGRESS IN RETINAL AND EYE RESEARCH. 1997;16(3):375-399

A membrane receptor for plasma retinol-binding protein (RBP) is expressed in the retinal pigment epithelium

Eriksson U
Article: BRAIN STRUCTURE & FUNCTION. 1997;195(6):483-490

Retinoid binding proteins in mouse yolk sac and chorio-allantoic placentas.

Johansson S; Gustafson AL; Donovan M; Romert A; Eriksson U; Dencker L
Article: ONCOGENE. 1997;14(20):2475-2483

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia.

Enholm B; Paavonen K; Ristimäki A; Kumar V; Gunji Y; Klefstrom J; Kivinen L; Laiho M; Olofsson B; Joukov V; Eriksson U; Alitalo K
Article: AUDITORY NEUROSCIENCE. 1997;3(4):415

Aminoglycoside ototoxicity: High affinity receptors are expressed in secretory epithelia

Ylikoski J; Pirvola U; Zhai SQ; Eriksson U; Solin ML; Miettinen A
Article: GENOMICS. 1996;36(3):424-430

Primary structure of human 11-cis retinol dehydrogenase and organization and chromosomal localization of the corresponding gene.

Simon A; Lagercrantz J; Bajalica-Lagercrantz S; Eriksson U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(32):19310-19317

Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform.

Olofsson B; Pajusola K; von Euler G; Chilov D; Alitalo K; Eriksson U
Article: MECHANISMS OF DEVELOPMENT. 1996;58(1-2):27-38

Nuclear import of cellular retinoic acid-binding protein type I in mouse embryonic cells.

Gustafson AL; Donovan M; Annerwall E; Dencker L; Eriksson U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(6):2576-2581

Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

Olofsson B; Pajusola K; Kaipainen A; von Euler G; Joukov V; Saksela O; Orpana A; Pettersson RF; Alitalo K; Eriksson U
Article: CIRCULATION. 1996;93(6):1079-1082

Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively.

Paavonen K; Horelli-Kuitunen N; Chilov D; Kukk E; Pennanen S; Kallioniemi OP; Pajusola K; Olofsson B; Eriksson U; Joukov V; Palotie A; Alitalo K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1995;210(1):105-112

Epitope mapping of a monoclonal antibody that blocks the binding of retinol-binding protein to its receptor.

Melhus H; Båvik CO; Rask L; Peterson PA; Eriksson U
Article: DEVELOPMENT. 1995;121(3):825-837

Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells.

Lee YM; Osumi-Yamashita N; Ninomiya Y; Moon CK; Eriksson U; Eto K
Article: EXPERIMENTAL CELL RESEARCH. 1995;216(2):358-362

Retinol-binding protein mediates uptake of retinol to cultured human keratinocytes.

Båvik CO; Peterson A; Eriksson U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(3):1107-1112

The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases.

Simon A; Hellman U; Wernstedt C; Eriksson U
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Editorial comment: CELL METABOLISM. 2018;27(6):1161-1162

Visualizing Fatty Acid Flux.

Eriksson U; Falkevall A
Review: PHARMACOLOGY & THERAPEUTICS. 2016;167:108-119

Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders.

Lewandowski SA; Fredriksson L; Lawrence DA; Eriksson U
Review: EUROPEAN JOURNAL OF HEART FAILURE. 2015;17(11):1091-1103

Intercellular communication lessons in heart failure.

Bang C; Antoniades C; Antonopoulos AS; Eriksson U; Franssen C; Hamdani N; Lehmann L; Moessinger C; Mongillo M; Muhl L; Speer T; Thum T
Editorial comment: EXPERIMENTAL NEUROLOGY. 2014;257:182-185

Response to the report, "A re-assessment of treatment with a tyrosine kinase inhibitor (imatinib) on tissue sparing and functional recovery after spinal cord injury" by Sharp et al.

Abrams MB; Nilsson I; Kjell J; Lewandowski S; Codeluppi S; Eriksson U; Olson L
Review: PHYSIOLOGY. 2013;28(2):125-134

Endothelial fatty acid transport: role of vascular endothelial growth factor B.

Hagberg C; Mehlem A; Falkevall A; Muhl L; Eriksson U
Meeting abstract: CANCER RESEARCH. 2013;73:b28

Signaling by PDGF-CC in the maintenance of a protumorigenic breast cancer microenvironment

Roswell P; Haller K; Petersson A; Anderberg C; Li H; Norum J-H; Toftgard R; Eriksson U; Pietras K
Published conference paper: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7 Suppl 1(Suppl 1):155-158

Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke.

Su EJ; Fredriksson L; Schielke GP; Eriksson U; Lawrence DA
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):31

THE EFFECT OF VEGF-A GENE TRANSFER ON ATHEROSCLEROSIS, LIPOPROTEIN PROFILES AND LPL ACTIVITY

Leppanen P; Heinonen SE; Olkkonen VM; Muilu M; Metso J; Eriksson U; Jauhianen M; Yla-Herttuala S
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2007;8(1):57

Gene transfers of VEGF-gene family have no effect on atherosclerosis in LDLR/ApoB48-deficient mice

Leppanen P; Koota S; Kholova I; Koponen J; Fieber C; Eriksson U; Alitalo K; Yla-Herttuala S
Review: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(19):13001-13004

Understanding retinol metabolism: structure and function of retinol dehydrogenases.

Lidén M; Eriksson U
Review: CYTOKINE & GROWTH FACTOR REVIEWS. 2004;15(4):197-204

The PDGF family: four gene products form five dimeric isoforms.

Fredriksson L; Li H; Eriksson U
Review: MOLECULAR ASPECTS OF MEDICINE. 2003;24(6):403-409

Structure and function of retinol dehydrogenases of the short chain dehydrogenase/reductase family.

Lidén M; Tryggvason K; Eriksson U
Review: CYTOKINE & GROWTH FACTOR REVIEWS. 2003;14(2):91-98

Novel PDGF family members: PDGF-C and PDGF-D.

Li X; Eriksson U
Editorial comment: NATURE MEDICINE. 2002;8(8):775-777

VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies.

Eriksson U; Alitalo K
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2001;33(4):421-426

Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.

Li X; Eriksson U
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2000;316:344-358

Analyzing membrane topology of 11-cis-retinol dehydrogenase.

Simon A; Romert A; Eriksson U
Review: CURRENT OPINION IN BIOTECHNOLOGY. 1999;10(6):528-535

Current biology of VEGF-B and VEGF-C.

Olofsson B; Jeltsch M; Eriksson U; Alitalo K
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 1999;237:41-57

Structure, expression and receptor-binding properties of novel vascular endothelial growth factors.

Eriksson U; Alitalo K
Review: METHODS IN MOLECULAR BIOLOGY. 1998;89:57-66

Immunohistochemistry for CRBPs and CRABPs.

Eriksson U; Gustafsson AL
Published conference paper: JOURNAL OF CELLULAR PHYSIOLOGY. 1997;173(2):211-215

Vascular endothelial growth factors VEGF-B and VEGF-C.

Joukov V; Kaipainen A; Jeltsch M; Pajusola K; Olofsson B; Kumar V; Eriksson U; Alitalo K
Addendum: MECHANISMS OF DEVELOPMENT. 1996;60(2):241

Nuclear import of cellular retinoic acid-binding protein type I in mouse embryonic cells (vol 58, pg 27, 1996)

Gustafson AL; Donovan M; Annerwall E; Dencker L; Eriksson U
Published conference paper: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 1995;53(1-6):459-465

The cellular retinoic acid binding proteins.

Donovan M; Olofsson B; Gustafson AL; Dencker L; Eriksson U
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