Vijay Joshua

Vijay Joshua Balasingh

Research Specialist

About me

I am a Postdoctoral Researcher at the Rheumatology Unit.


Research description

I have been working on studies that try to understand the role of the lungs in the initiation of Rheumatoid Arthritis (RA). More specifically, I have been studying the immunogenetics and Citrulline reactivity of the lung B cells in lungs of risk RA and early untreated RA.


List of Publications

Original articles

Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis. Roos Ljungberg K, Joshua V, Skogh T, Eklund A, Sköld CM, Karimi R, Nyrén S, Svärd A, Catrina AI, Kastbom A. Rheumatology (Oxford). 2019 Sep.

Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts. Sun M, Rethi B, Krishnamurthy A, Joshua V, Circiumaru A, Hensvold AH, Ossipova E, Grönwall C, Liu Y, Engstrom M, Catrina SB, Steen J, Malmstrom V, Klareskog L, Svensson C, Ospelt C, Wähämaa H, Catrina AI. Ann Rheum Dis. 2019.

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts. Krishnamurthy A, Ytterberg AJ, Sun M, Sakuraba K, Steen J, Joshua V, Tarasova NK, Malmström V, Wähämaa H, Réthi B, Catrina AI. J Immunol. 2019 Jun.

Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells. Joshua V, Schobers L, Titcombe PJ, Israelsson L, Rönnelid J, Hansson M, Catrina AI, Pruijn GJ, Malmström V. Arthritis Res Ther. 2016 Dec 1.

The lung microbiota in early rheumatoid arthritis and autoimmunity. Scher JU, Joshua V, Artacho A, Abdollahi-Roodsaz S, Öckinger J, Kullberg S, Sköld M, Eklund A, Grunewald J, Clemente JC, Ubeda C, Segal LN, Catrina AI. Microbiome. 2016 Nov 17.

Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated formBoggavarapu NR, Lalitkumar S, Joshua V, Kasvandik S, Salumets A, Lalitkumar PG, Gemzell-Danielsson K. Sci Rep. 2016 Sep 26.

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone lossKrishnamurthy A, Joshua V, Haj Hensvold A, Jin T, Sun M, Vivar N, Ytterberg AJ, Engström M, Fernandes-Cerqueira C, Amara K, Magnusson M, Wigerblad G, Kato J, Jiménez-Andrade JM, Tyson K, Rapecki S, Lundberg K, Catrina SB, Jakobsson PJ, Svensson C, Malmström V, Klareskog L, Wähämaa H, Catrina AI. Ann Rheum Dis. 2015 Nov 26.

Signs of immune activation and local inflammation are present in the bronchial tissue of patients with untreated early rheumatoid arthritisReynisdottir G, Olsen H, Joshua V, Engström M, Forsslund H, Karimi R, Sköld CM, Nyren S, Eklund A, Grunewald J, Catrina AI. Ann Rheum Dis. 2015 Nov 3.

Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexateHensvold AH, Joshua V, Li W, Larkin M, Qureshi F, Israelsson L, Padyukov L, Lundberg K, Defranoux N, Saevarsdottir S, Catrina AI. Arthritis Res Ther. 2015 Sep 4.

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validationYtterberg AJ, Joshua V, Reynisdottir G, Tarasova NK, Rutishauser D, Ossipova E, Haj Hensvold A, Eklund A, Sköld CM, Grunewald J, Malmström V, Jakobsson PJ, Rönnelid J, Padyukov L, Zubarev RA, Klareskog L, Catrina AI. Ann Rheum Dis. 2015 Sep.

Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twinsHensvold AH, Magnusson PK, Joshua V, Hansson M, Israelsson L, Ferreira R, Jakobsson PJ, Holmdahl R, Hammarström L, Malmström V, Askling J, Klareskog L, Catrina AI. Ann Rheum Dis. 2015 Feb.

Structural changes and antibody enrichment in the lungs are early features of anti-citrullinated protein antibody-positive rheumatoid arthritisReynisdottir G, Karimi R, Joshua V, Olsen H, Hensvold AH, Harju A, Engström M, Grunewald J, Nyren S, Eklund A, Klareskog L, Sköld CM, Catrina AI. Arthritis Rheumatol. 2014 Jan.



Role of the lung in individuals at risk of rheumatoid arthritisJoshua V, Chatzidionisyou K, Catrina AI. Best Pract Res Clin Rheumatol. 2017 Feb. Review.

Mechanisms involved in triggering rheumatoid arthritisCatrina AI, Joshua V, Klareskog L, Malmström V. Immunol Rev. 2016 Jan. Review.


Student Project 

If you are interested projects involving Antibody cloning from Single B cells, don't hesitate to write to us. We are always looking for enthusiastic Bachelors or Masters students.

Teaching portfolio

Course Organiser

Cytokines in Inflammation (PhD Course - 3 ECTS - 2 Weeks ) - 2021, 2022


Cytokines in Inflammation (PhD Course - 3 ECTS - 2 Weeks ) - 2019, 2021, 2022


2003 - 2007 BTech (Industrial Biotechnology), Kumaraguru College of Technology, Coimbatore, India

2009 - 2011 MSc (Computational and Systems Biology), The Royal Institute of Technology, Stockholm, Sweden

2012 - 2017 PhD (Autoimmunity in Rheumatoid arthritis), Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden

PhD Thesis - 'Antibody-associated inflammation in and outside the joint in rheumatoid arthritis'