Xaquin Castro Dopico

About me
Publications
Public outreach and news

About me

Immunologist-veterinarian interested in gene-environment interactions and molecular mechanisms in adaptive immunity

Research

Primary samples &
comparative immunology
antigen-specific T and B cell responses
lymphocyte metabolism
antibody therapies and vaccines.

Articles

Article: JCI INSIGHT. 2023;8(17):e167656

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations.

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; McInerney G; Murrell B; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam GB; Castro Dopico X; Rorbach J
Article: OPEN BIOLOGY. 2023;13(5):220369

Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.

Schulte T; Panas MD; Han X; Williams L; Kedersha N; Fleck JS; Tan TJC; Dopico XC; Olsson A; Morro AM; Hanke L; Nilvebrant J; Giang KA; Nygren P-Å; Anderson P; Achour A; McInerney GM
Article: CELLS. 2023;12(9):1229

Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells.

Adori M; Khoenkhoen S; Zhang J; Dopico XC; Karlsson Hedestam GB
Article: FRONTIERS IN VIROLOGY. 2023;3:1128253

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses.

Pushparaj P; Nicoletto A; Dopico XC; Sheward DJ; Kim S; Ekström S; Murrell B; Corcoran M; Karlsson Hedestam GB
Article: NUCLEIC ACIDS RESEARCH. 2023;51(2):891-907

Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria.

Remes C; Khawaja A; Pearce SF; Dinan AM; Gopalakrishna S; Cipullo M; Kyriakidis V; Zhang J; Dopico XC; Yukhnovets O; Atanassov I; Firth AE; Cooperman B; Rorbach J
Article: LANCET INFECTIOUS DISEASES. 2022;22(6):813-820

Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study.

Sheward DJ; Kim C; Ehling RA; Pankow A; Castro Dopico X; Dyrdak R; Martin DP; Reddy ST; Dillner J; Karlsson Hedestam GB; Albert J; Murrell B
Article: CELLULAR IMMUNOLOGY. 2022;375:104516

Impaired plasma cell differentiation associates with increased oxidative metabolism in IκBNS-deficient B cells.

Erikson E; Ádori M; Khoenkhoen S; Zhang J; Rorbach J; Castro Dopico X; Karlsson Hedestam G
Article: JOURNAL OF INFECTIOUS DISEASES. 2022;225(6):965-970

Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms.

Cunningham JL; Virhammar J; Rönnberg B; Dopico XC; Kolstad L; Albinsson B; Kumlien E; Nääs A; Klang A; Westman G; Zetterberg H; Frithiof R; Lundkvist Å; Karlsson Hedestam GB; Rostami E
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379

Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates.

Castro Dopico X; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikström L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Karlsson Hedestam GB
Article: CELL REPORTS MEDICINE. 2021;2(11):100450

Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models.

Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Perez Vidakovics L; Pankow A; Smith NL; Castro Dopico X; McInerney GM; Coquet JM; Karlsson Hedestam GB; Murrell B
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):666-676

Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.

Castro Dopico X; Muschiol S; Christian M; Hanke L; Sheward DJ; Grinberg NF; Rorbach J; Bogdanovic G; Mcinerney GM; Allander T; Wallace C; Murrell B; Albert J; Karlsson Hedestam GB
Article: CELL REPORTS MEDICINE. 2021;2(4):100252

SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses.

Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Àdori M; Lenart K; Loré K; Castro Dopico X; Coquet JM; McInerney GM; Karlsson Hedestam GB; Murrell B
Article: IMMUNITY. 2021;54(2):355-366.e4

Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles.

Vázquez Bernat N; Corcoran M; Nowak I; Kaduk M; Castro Dopico X; Narang S; Maisonasse P; Dereuddre-Bosquet N; Murrell B; Karlsson Hedestam GB
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2606

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.

Ferreira RC; Castro Dopico X; Oliveira JJ; Rainbow DB; Yang JH; Trzupek D; Todd SA; McNeill M; Steri M; Orrù V; Fiorillo E; Crouch DJM; Pekalski ML; Cucca F; Tree TI; Vyse TJ; Wicker LS; Todd JA
Article: JOURNAL OF AUTOIMMUNITY. 2017;84:75-86

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity.

Ferreira RC; Simons HZ; Thompson WS; Rainbow DB; Yang X; Cutler AJ; Oliveira J; Castro Dopico X; Smyth DJ; Savinykh N; Mashar M; Vyse TJ; Dunger DB; Baxendale H; Chandra A; Wallace C; Todd JA; Wicker LS; Pekalski ML
Article: GENOME BIOLOGY. 2017;18(1):165

Chromosome contacts in activated T cells identify autoimmune disease candidate genes.

Burren OS; Rubio García A; Javierre B-M; Rainbow DB; Cairns J; Cooper NJ; Lambourne JJ; Schofield E; Castro Dopico X; Ferreira RC; Coulson R; Burden F; Rowlston SP; Downes K; Wingett SW; Frontini M; Ouwehand WH; Fraser P; Spivakov M; Todd JA; Wicker LS; Cutler AJ; Wallace C
Article: JCI INSIGHT. 2017;2(16):93739

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

Pekalski ML; García AR; Ferreira RC; Rainbow DB; Smyth DJ; Mashar M; Brady J; Savinykh N; Dopico XC; Mahmood S; Duley S; Stevens HE; Walker NM; Cutler AJ; Waldron-Lynch F; Dunger DB; Shannon-Lowe C; Coles AJ; Jones JL; Wallace C; Todd JA; Wicker LS
Article: HYPERTENSION. 2017;70(3):HYPERTENSIONAHA.117.09242-633

Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome.

Coan PM; Barrier M; Alfazema N; Carter RN; Marion de Procé S; Dopico XC; Garcia Diaz A; Thomson A; Jackson-Jones LH; Moyon B; Webster Z; Ross D; Moss J; Arends MJ; Morton NM; Aitman TJ
Article: NATURE COMMUNICATIONS. 2015;6:7000

Widespread seasonal gene expression reveals annual differences in human immunity and physiology.

Dopico XC; Evangelou M; Ferreira RC; Guo H; Pekalski ML; Smyth DJ; Cooper N; Burren OS; Fulford AJ; Hennig BJ; Prentice AM; Ziegler A-G; Bonifacio E; Wallace C; Todd JA
Article: DIABETOLOGIA. 2015;58(4):781-790

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients.

Ferreira RC; Simons HZ; Thompson WS; Cutler AJ; Dopico XC; Smyth DJ; Mashar M; Schuilenburg H; Walker NM; Dunger DB; Wallace C; Todd JA; Wicker LS; Pekalski ML
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2014;177(3):571-585

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes.

Thompson WS; Pekalski ML; Simons HZ; Smyth DJ; Castro-Dopico X; Guo H; Guy C; Dunger DB; Arif S; Peakman M; Wallace C; Wicker LS; Todd JA; Ferreira RC
Article: JOURNAL OF IMMUNOLOGY. 2013;190(6):2554-2566

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.

Pekalski ML; Ferreira RC; Coulson RMR; Cutler AJ; Guo H; Smyth DJ; Downes K; Dendrou CA; Castro Dopico X; Esposito L; Coleman G; Stevens HE; Nutland S; Walker NM; Guy C; Dunger DB; Wallace C; Tree TIM; Todd JA; Wicker LS
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All other publications

Preprint: BIORXIV. 2022

A semi-supervised Bayesian mixture modelling approach for joint batch correction and classification

Coleman S; Nicholls K; Nicholls K; Dopico XC; Karlsson Hedestam G; Kirk PDW; Wallace C
Editorial comment: IMMUNITY. 2022;55(1):8-10

A family matter: Anti-viral antibody responses.

Castro Dopico X; Karlsson Hedestam GB
Review: JOURNAL OF INTERNAL MEDICINE. 2022;291(1):32-50

Immunity to SARS-CoV-2 induced by infection or vaccination.

Castro Dopico X; Ols S; Loré K; Karlsson Hedestam GB
Preprint: BIORXIV. 2021

Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)

Sheward D; Kim C; Ehling R; Pankow A; Dopico XC; Martin D; Reddy S; Dillner J; Karlsson Hedestam G; Albert J; Murrell B
Preprint: MEDRXIV. 2021

Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
Preprint: BIORXIV. 2021

Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost

Sheward D; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith N; Dopico XC; McInerney G; Coquet J; Hedestam GK; Murrell B
Review: JOURNAL OF BIOLOGICAL RHYTHMS. 2021;36(1):35-54

Drivers of Infectious Disease Seasonality: Potential Implications for COVID-19.

Kronfeld-Schor N; Stevenson TJ; Nickbakhsh S; Schernhammer ES; Dopico XC; Dayan T; Martinez M; Helm B
Preprint: MEDRXIV. 2020

Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden

Dopico XC; Muschiol S; Christian M; Hanke L; Sheward D; Grinberg N; Rorbach J; Bogdanovic G; Mcinerney G; Allander T; Wallace C; Murrell B; Albert J; Hedestam GK
Preprint: BIORXIV. 2020

SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses

Mandolesi M; Sheward D; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Loré K; Castro Dopico X; Coquet J; McInerney G; Karlsson Hedestam G; Murrell B
Preprint: MEDRXIV. 2020

Probabilistic approaches for classifying highly variable anti-SARS-CoV-2 antibody responses

Dopico X; Hanke L; Sheward D; Muschiol S; Aleman S; Grinberg N; Adori M; Christian M; Vidakovics LP; Kim C; Khoenkhoen S; Pushparaj P; Morro AM; Mandolesi M; Ahl M; Forsell M; Coquet J; Corcoran M; Rorbach J; Dillner J; Bogdanovic G; McInerney G; Allander T; Murrell B; Wallace C; Albert J; Karlsson Hedestam G

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