Xiaoyuan Ren

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Articles

Journal article: ANTIOXIDANTS. 2023;12(6):1180

Disruption of Bacterial Thiol-Dependent Redox Homeostasis by Magnolol and Honokiol as an Antibacterial Strategy.

Ouyang Y; Tang X; Zhao Y; Zuo X; Ren X; Wang J; Zou L; Lu J
Article: MOLECULAR THERAPY. 2023;31(3):825-846

Photoreceptor laminin drives differentiation of human pluripotent stem cells to photoreceptor progenitors that partially restore retina function.

Tay HG; Andre H; Chrysostomou V; Adusumalli S; Guo J; Ren X; Tan WS; Tor JE; Moreno-Moral A; Plastino F; Bartuma H; Cai Z; Tun SBB; Barathi VA; Siew Wei GT; Grenci G; Chong LY; Holmgren A; Kvanta A; Crowston JG; Petretto E; Tryggvason K
Journal article: REDOX BIOLOGY. 2022;57:102510

Modulating antioxidant systems as a therapeutic approach to retinal degeneration.

Ren X; Léveillard T
Journal article: ANTIOXIDANTS. 2022;11(9):1643

Mitochondrial Glrx2 Knockout Augments Acetaminophen-Induced Hepatotoxicity in Mice.

Li J; Tang X; Wen X; Ren X; Zhang H; Du Y; Lu J
Article: ANALYST. 2022;147(5):834-840

A fluorescent probe for specifically measuring the overall thioredoxin and glutaredoxin reducing activity in bacterial cells.

Zuo X; Zhao Y; Zhao J; Ouyang Y; Qian W; Hou Y; Yu C; Ren X; Zou L; Fang J; Lu J
Article: ANTIOXIDANTS & REDOX SIGNALING. 2021;34(17):1355-1367

Selenium Status in Diet Affects Acetaminophen-Induced Hepatotoxicity via Interruption of Redox Environment.

Li J; Cheng P; Li S; Zhao P; Han B; Ren X; Zhong JL; Lloyd MD; Pourzand C; Holmgren A; Lu J
Article: BIOCHEMICAL PHARMACOLOGY. 2020;175:113873

Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury.

Cheng P; Liu H; Li Y; Pi P; Jiang Y; Zang S; Li X; Fu A; Ren X; Xu J; Holmgren A; Lu J
Article: METALLOMICS. 2019;11(9):1490-1497

The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase.

Li J; Zuo X; Cheng P; Ren X; Sun S; Xu J; Holmgren A; Lu J
Article: FEBS LETTERS. 2019;593(14):1799-1806

Characterization of mammalian glutaredoxin isoforms as S-denitrosylases.

Ren X; Sengupta R; Lu J; Lundberg JO; Holmgren A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2019;134:350-358

The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress.

Ren X; Santhosh SM; Coppo L; Ogata FT; Lu J; Holmgren A
Article: FRONTIERS IN MICROBIOLOGY. 2019;10:3016

Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase.

Dong C; Zhou J; Wang P; Li T; Zhao Y; Ren X; Lu J; Wang J; Holmgren A; Zou L
Article: SCIENTIFIC REPORTS. 2018;8(1):12671

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246.

Haffo L; Lu J; Bykov VJN; Martin SS; Ren X; Coppo L; Wiman KG; Holmgren A
Article: SCIENTIFIC REPORTS. 2018;8(1):11131

Synergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production.

Zou L; Wang J; Gao Y; Ren X; Rottenberg ME; Lu J; Holmgren A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(40):10737-10742

Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK.

Jiang Y; Lin X; Tang Z; Lee C; Tian G; Du Y; Yin X; Ren X; Huang L; Ye Z; Chen W; Zhang F; Mi J; Gao Z; Wang S; Chen Q; Xing L; Wang B; Cao Y; Sessa WC; Ju R; Liu Y; Li X
Article: EMBO MOLECULAR MEDICINE. 2017;9(8):1165-1178

Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections.

Zou L; Lu J; Wang J; Ren X; Zhang L; Gao Y; Rottenberg ME; Holmgren A
Article: PLOS PATHOGENS. 2016;12(2):e1005442

Nitric Oxide Protects against Infection-Induced Neuroinflammation by Preserving the Stability of the Blood-Brain Barrier.

Olivera GC; Ren X; Vodnala SK; Lu J; Coppo L; Leepiyasakulchai C; Holmgren A; Kristensson K; Rottenberg ME
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2015;89:192-200

Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1.

Zhang X; Lu J; Ren X; Du Y; Zheng Y; Ioannou PV; Holmgren A
Article: ANTI-CANCER DRUGS. 2011;22(8):732-740

Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy.

Wang L; Fu J-N; Wang J-Y; Jin C-J; Ren X-Y; Tan Q; Li J; Yin H-W; Xiong K; Wang T-Y; Liu X-M; Zeng H-H
Article: INVESTIGATIONAL NEW DRUGS. 2011;29(4):627-636

Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.

Fu J-N; Li J; Tan Q; Yin H-W; Xiong K; Wang T-Y; Ren X-Y; Zeng H-H
Article: DIFFERENTIATION. 2011;81(1):49-56

Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity.

Yin H; Li J; Xiong K; Wang L; Wang T; Tan Q; Fu J; Ren X; Zeng H
Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2010;391(1-2):292-304

Preparation of tri-block copolymer micelles loading novel organoselenium anticancer drug BBSKE and study of tissue distribution of copolymer micelles by imaging in vivo method.

Liu M; Fu J; Li J; Wang L; Tan Q; Ren X; Peng Z; Zeng H
Journal article: CHINESE JOURNAL OF CANCER. 2009;28(5):472-477

[Correlation of plasma thioredoxin reductase activity to growth of H22 hepatocellular carcinoma xenografts in Kunming mice].

Tan Q; Ren X-Y; Li J; Wang F; Deng S-J; Zeng H-H
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Preprint: BIORXIV. 2022

The Emergence of the Metabolic Signaling of the Nucleoredoxin-like Genes during Evolution

Aït-Ali N; Blond F; Clérin E; Morshedian A; Cesar Q; Delalande F; Koyanagi M; Birck C; Han J; Ren X; van Dorsselaer A; Terakita A; Fain GL; Léveillard T
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022;63(7)

The potential role of rod-derived cone viability factor long (RdCVFL) in treating retinitis pigmentosa as a thioredoxin-like protein

Ren X; Holmgren A; Arner ESJ; Leveillard TD
Review: CURRENT MEDICINAL CHEMISTRY. 2020;27(12):1922-1939

Targeting Bacterial Antioxidant Systems for Antibiotics Development.

Ren X; Zou L; Holmgren A
Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;127:238-247

Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic.

Ren X; Zou L; Lu J; Holmgren A
Book chapter: OXIDATIVE FOLDING OF PROTEINS. 2018;p. 355-378

CHAPTER 4.4 Thioredoxin and Cellular Redox Systems: Beyond Protein Disulfide Bond Reduction

Ren X; Lu J; Holmgren A
Review: ANTIOXIDANTS & REDOX SIGNALING. 2017;27(13):989-1010

Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System.

Ren X; Zou L; Zhang X; Branco V; Wang J; Carvalho C; Holmgren A; Lu J
KI thesis / dissertation: 2017

Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress

Ren, Xiaoyuan
Book chapter: ORGANOSELENIUM COMPOUNDS IN BIOLOGY AND MEDICINE. 2017;p. 303-316

Chapter 11 Ebselen and Thioredoxin Systems in Human Health, Disease and Therapeutic Potential

Lu J; Ren X; Zou L; Holmgren A

Grants

Redox regulation of HNRNPC, an epigenetic node in Alzheimer’s disease

Swedish Research Council

1 July 2019 - 30 June 2022

Employments

Affiliated to Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-2026

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2017
Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2012

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