Xiao-Wei Zheng

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About me

I am a cardiologist, and I got my Ph.D. at the Department of Cell and Molecular Biology of Karolinska Institutet. Now I am working as Senior Research Specialist at the Department of Molecular Medicine and Surgery, Karolinska Institutet.

Research

We investigate new pathogenic mechanisms of diabetes complications. The major focuses are how diabetes affects hypoxia, Notch and other signaling pathways and how this contributes to the development of diabetes complications including diabetic nephropathy, diabetic foot ulcer, infection and diabetic heart disease. We use clinical samples together with animal and cellular models of diabetes as well as genetically-modified mice to conduct mechanistical, translational, and clinical research.

Articles

Article: ANTIOXIDANTS. 2023;12(12):2043

Comparing the Blood Response to Hyperbaric Oxygen with High-Intensity Interval Training-A Crossover Study in Healthy Volunteers.

Kjellberg A; Lindholm ME; Zheng X; Liwenborg L; Rodriguez-Wallberg KA; Catrina S-B; Lindholm P
Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(17):e167693

Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP.

Yang J; Sundqvist ML; Zheng X; Jiao T; Collado A; Tratsiakovich Y; Mahdi A; Tengbom J; Mergia E; Catrina S-B; Zhou Z; Carlström M; Akaike T; Cortese-Krott MM; Weitzberg E; Lundberg JO; Pernow J
Article: JOURNAL OF AUTOIMMUNITY. 2022;133:102903

Autoantibodies targeting malondialdehyde-modifications in rheumatoid arthritis regulate osteoclasts via inducing glycolysis and lipid biosynthesis.

Sakuraba K; Krishnamurthy A; Sun J; Zheng X; Xu C; Peng B; Engström M; Jakobsson P-J; Wermeling F; Catrina S; Grönwall C; Catrina AI; Réthi B
Article: BMJ OPEN. 2022;12(11):e061870

Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trial.

Kjellberg A; Abdel-Halim L; Hassler A; El Gharbi S; Al-Ezerjawi S; Boström E; Sundberg CJ; Pernow J; Medson K; Kowalski JH; Rodriguez-Wallberg KA; Zheng X; Catrina S; Runold M; Ståhlberg M; Bruchfeld J; Nygren-Bonnier M; Lindholm P
Article: MBIO. 2022;13(5):e0108622-e01022

High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages.

Terán G; Li H; Catrina S-B; Liu R; Brighenti S; Zheng X; Grünler J; Nylén S; Carow B; Rottenberg ME
Article: ELIFE. 2022;11:e70714

Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes.

Zheng X; Narayanan S; Xu C; Eliasson Angelstig S; Grünler J; Zhao A; Di Toro A; Bernardi L; Mazzone M; Carmeliet P; Del Sole M; Solaini G; Forsberg EA; Zhang A; Brismar K; Schiffer TA; Rajamand Ekberg N; Botusan IR; Palm F; Catrina S-B
Article: DIABETES. 2022;71(2):285-297

Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes.

Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: BMJ OPEN. 2021;11(7):e046738

Randomised, controlled, open label, multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission, morbidity and mortality in adult patients with COVID-19.

Kjellberg A; Douglas J; Pawlik MT; Kraus M; Oscarsson N; Zheng X; Bergman P; Frånberg O; Kowalski JH; Nyren SP; Silvanius M; Skold M; Catrina S-B; Rodriguez-Wallberg KA; Lindholm P
Article: ANTIOXIDANTS. 2021;10(7):1070

Dehydro-Tocotrienol-β Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice.

Dallner G; Bentinger M; Hussain S; Sinha I; Yang J; Schwank-Xu C; Zheng X; Swiezewska E; Brismar K; Valladolid-Acebes I; Tekle M
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(3):659-671

miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes.

Li D; Peng H; Qu L; Sommar P; Wang A; Chu T; Li X; Bi X; Liu Q; Gallais Sérézal I; Rollman O; Lohcharoenkal W; Zheng X; Eliasson Angelstig S; Grünler J; Pivarcsi A; Sonkoly E; Catrina S-B; Xiao C; Ståhle M; Mi Q-S; Zhou L; Xu Landén N
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):768

HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism.

Narayanan S; Eliasson Angelstig S; Xu C; Grünler J; Zhao A; Zhu W; Xu Landén N; Ståhle M; Zhang J; Ivan M; Maltesen RG; Botusan IR; Rajamand Ekberg N; Zheng X; Catrina S-B
Article: EBIOMEDICINE. 2019;44:489-501

Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.

Petrus P; Fernandez TL; Kwon MM; Huang JL; Lei V; Safikhan NS; Karunakaran S; O'Shannessy DJ; Zheng X; Catrina S-B; Albone E; Laine J; Virtanen K; Clee SM; Kieffer TJ; Noll C; Carpentier AC; Johnson JD; Rydén M; Conway EM
Article: JOURNAL OF DIABETES RESEARCH. 2019;2019:2936962-8

Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy.

Ekberg NR; Eliasson S; Li YW; Zheng X; Chatzidionysiou K; Falhammar H; Gu HF; Catrina S-B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(14):6985-6994

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.

Zheng X; Narayanan S; Sunkari VG; Eliasson S; Botusan IR; Grünler J; Catrina AI; Radtke F; Xu C; Zhao A; Ekberg NR; Lendahl U; Catrina S-B
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(138)

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions.

Zheng X; Ho CQW; Zheng X; Lee KL; Gradin K; Pereira TS; Berggren P-O; Ali Y
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):450-463

Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species.

Yang J; Zheng X; Mahdi A; Zhou Z; Tratsiakovich Y; Jiao T; Kiss A; Kövamees O; Alvarsson M; Catrina S-B; Lundberg JO; Brismar K; Pernow J
Article: PLOS ONE. 2018;13(3):e0193084

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate.

Botusan IR; Zheng X; Narayanan S; Grünler J; Sunkari VG; Calissendorff FS; Ansurudeen I; Illies C; Svensson J; Jansson J-O; Ohlsson C; Brismar K; Catrina S-B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638

MicroRNA-132 with Therapeutic Potential in Chronic Wounds.

Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grünler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrström M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Ståhle M; Xu Landén N
Article: EXPERIMENTAL CELL RESEARCH. 2017;358(2):129-139

A Notch-independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells.

Zheng X; Narayanan S; Zheng X; Luecke-Johansson S; Gradin K; Catrina S-B; Poellinger L; Pereira TS
Article: ACTA PHYSIOLOGICA. 2014;210(3):590-599

Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors.

Yang J; Zheng X; Haugen F; Darè E; Lövdahl C; Schulte G; Fredholm BB; Valen G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):2560-2565

Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response.

Zheng X; Zhou A-X; Rouhi P; Uramoto H; Borén J; Cao Y; Pereira T; Akyürek LM; Poellinger L
Article: DIABETES CARE. 2013;36(2):415-421

Impact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy.

Gu HF; Zheng X; Abu Seman N; Gu T; Botusan IR; Sunkari VG; Lokman EF; Brismar K; Catrina S-B
Article: CELL DEATH & DISEASE. 2012;3(6):e322

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.

Zheng X; Zheng X; Wang X; Ma Z; Gupta Sunkari V; Botusan I; Takeda T; Björklund A; Inoue M; Catrina S-B; Brismar K; Poellinger L; Pereira TS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
Article: CELL CYCLE. 2006;5(23):2720-2722

Degradation of the hypoxia-inducible factor 1alpha: where does it happen?

Pereira T; Zheng X; Poellinger L
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.

Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628

Hypoxia requires notch signaling to maintain the undifferentiated cell state.

Gustafsson MV; Zheng X; Pereira T; Gradin K; Jin S; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):6816-6823

Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.

Pereira T; Zheng X; Ruas JL; Tanimoto K; Poellinger L
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All other publications

Corrigendum: JOURNAL OF DIABETES RESEARCH. 2021;2021:9827150-1

Corrigendum to "Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy".

Ekberg NR; Eliasson S; Li YW; Zheng X; Chatzidionysiou K; Falhammar H; Gu HF; Catrina S-B
Review: DIABETOLOGIA. 2021;64(4):709-716

Hypoxia and hypoxia-inducible factors in diabetes and its complications.

Catrina S-B; Zheng X
Letter: CLINICAL AND TRANSLATIONAL MEDICINE. 2021;11(1):e273

Repressed hypoxia inducible factor-1 in diabetes aggravates pulmonary aspergillus fumigatus infection through modulation of inflammatory responses.

Ye Y; Chen Y; Sun J; Zhang H; Li W; Wang W; Zheng X; Catrina S-B
Published paper: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2016;32 Suppl 1:179-185

Disturbed hypoxic responses as a pathogenic mechanism of diabetic foot ulcers.

Catrina S-B; Zheng X
Editorial comment: ENDOCRINE. 2014;46(2):347-350

Selective blockade of estrogen receptor beta improves wound healing in diabetes.

Sunkari VG; Botusan IR; Savu O; Grünler J; Zheng X; Gustafsson J-Å; Brismar K; Catrina S-B

Employments

Senior Research Specialist, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2009

About me

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