Yaakov Ariel Levine

About me
Publications
Public outreach and news

Research

PhD
Biomedical Engineering

Articles

Article: JOURNAL OF CROHNS & COLITIS. 2023;17(12):1897-1909

Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn's Disease Patients: A Prospective Open-label Study.

D'Haens G; Eberhardson M; Cabrijan Z; Danese S; van den Berg R; Löwenberg M; Fiorino G; Schuurman PR; Lind G; Almqvist P; Olofsson PS; Tracey KJ; Hanauer SB; Zitnik R; Chernoff D; Levine YA
Journal article: NEUROMODULATION. 2022;25(7):s149

O122 / #676 VAGUS NERVE STIMULATION TO TREAT RHEUMATOID ARTHRITIS: RATIONALE, OBJECTIVES AND DESIGN OF THE RESET-RA STUDY TRACK 3: VAGUS NERVE STIMULATION / TOOLS TO INFORM PATIENT CARE

Richardson M; Curtis J; Evangelista M; Levine Y; Chernoff D
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(Suppl 1):355-356

POS0236 SAFETY AND EFFICACY OF NEUROSTIMULATION WITH A MINIATURIZED VAGUS NERVE STIMULATION DEVICE IN PATIENTS WITH MULTIDRUG-REFRACTORY RHEUMATOID ARTHRITIS: 24-WEEK FOLLOW-UP OF A RANDOMIZED CONTROLLED FIRST-IN-HUMAN TRIAL

Gaylis N; Genovese MC; Sikes D; Kivitz A; Horowitz DM; Peterfy C; Levine Y; Evangelista M; Chernoff D
Article: FRONTIERS IN NEUROSCIENCE. 2021;15:730407

Vagus Nerve Stimulation Reduces Indomethacin-Induced Small Bowel Inflammation.

Caravaca AS; Levine YA; Drake A; Eberhardson M; Olofsson PS
Journal article: LANCET RHEUMATOLOGY. 2021;3(1):e14-e15

Vagus nerve stimulation in rheumatoid arthritis - Authors' reply.

Genovese MC; Levine YA; Chernoff D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(47):29803-29810

Identification of a brainstem locus that inhibits tumor necrosis factor.

Kressel AM; Tsaava T; Levine YA; Chang EH; Addorisio ME; Chang Q; Burbach BJ; Carnevale D; Lembo G; Zador AM; Andersson U; Pavlov VA; Chavan SS; Tracey KJ
Article: LANCET RHEUMATOLOGY. 2020;2(9):E527-E538

Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study.

Genovese MC; Gaylis NB; Sikes D; Kivitz A; Lewis Horowitz D; Peterfy C; Glass EV; Levine YA; Chernoff D
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(Suppl 1):1948.2-191949

AB1318-HPR VAGUS NERVE STIMULATION IN PATIENTS WITH RHEUMATOID ARTHRITIS: 48 MONTH SAFETY AND EFFICACY

Koopman F; Musters A; Backer M; Gerlag D; Miljko S; Grazio S; Sokolovic S; Levine Y; Glass E; Chernoff D; De Vries N; Tak PP
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2020;10(1):a034330

Harnessing the Inflammatory Reflex for the Treatment of Inflammation-Mediated Diseases.

Levine YA; Faltys M; Chernoff D
Journal article: GASTROENTEROLOGY. 2019;156(6):s-75

367 – Vagus Nerve Stimulation Reduces Disease Activity and Modulates Serum and Autonomic Biomarkers in Biologicrefractory Crohn's Disease

D’Haens GR; Cabrijan Z; Eberhardson M; van den Berg RM; Löwenberg M; Danese S; Fiorino G; Levine YA; Chernof DN
Journal article: BRAIN STIMULATION. 2019;12(2):e20-e21

Abstract #58: First-in-Class Neuromodulation Therapy in Subjects with Rheumatoid Arthritis: Two-Year Safety and Efficacy

Chernoff DN; Levine YA
Article: FRONTIERS IN NEUROSCIENCE. 2019;13:877

An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation.

Caravaca AS; Gallina AL; Tarnawski L; Tracey KJ; Pavlov VA; Levine YA; Olofsson PS
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:585

Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation.

Lehner KR; Silverman HA; Addorisio ME; Roy A; Al-Onaizi MA; Levine Y; Olofsson PS; Chavan SS; Gros R; Nathanson NM; Al-Abed Y; Metz CN; Prado VF; Prado MAM; Tracey KJ; Pavlov VA
Article: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2018;2018:3689-3692

Neurophysiologic and Chronic Safety Testing of a Miniaturized Active Implanted Device with Integrated Electrodes for Bioelectronic Medicine Applications.

Levine YA; Simon J; Faltys M
Journal article: GASTROENTEROLOGY. 2018;154(6):s-847

Mo1906 - The Effects of Vagus Nerve Stimulation in Biologicrefractory Crohn's Disease: A Prospective Clinical Trial

D'Haens GR; Cabrijan Z; Eberhardson M; van den Berg RM; Löwenberg M; Fiorino G; Danese S; Levine YA; Chernoff D
Journal article: JOURNAL OF CROHNS & COLITIS. 2018;12(supplement_1):s397-s398

P574 The effects of vagus nerve stimulation in biologic-refractory Crohn’s disease: A prospective clinical trial

D'Haens G; Cabrijan Z; Eberhardson M; van den Bergh R; Löwenberg M; Fiorino G; Danese S; Levine Y; Chernoff D
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:2648

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.

Tarnawski L; Reardon C; Caravaca AS; Rosas-Ballina M; Tusche MW; Drake AR; Hudson LK; Hanes WM; Li JH; Parrish WR; Ojamaa K; Al-Abed Y; Faltys M; Pavlov VA; Andersson U; Chavan SS; Levine YA; Mak TW; Tracey KJ; Olofsson PS
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:2032

Constitutive Vagus Nerve Activation Modulates Immune Suppression in Sepsis Survivors.

Rana M; Fei-Bloom Y; Son M; La Bella A; Ochani M; Levine YA; Chiu PY; Wang P; Chavan SS; Volpe BT; Sherry B; Diamond B
Article: MOLECULAR MEDICINE. 2016;22:585-596

Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice.

Hudson LK; Dancho ME; Li J; Bruchfeld JB; Ragab AA; He MM; Bragg M; Lenaghan D; Quinn MD; Fritz JR; Tanzi MV; Silverman HA; Hanes WM; Levine YA; Pavlov VA; Olofsson PS; Roth J; Al-Abed Y; Andersson U; Tracey KJ; Chavan SS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(29):8284-8289

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis.

Koopman FA; Chavan SS; Miljko S; Grazio S; Sokolovic S; Schuurman PR; Mehta AD; Levine YA; Faltys M; Zitnik R; Tracey KJ; Tak PP
Article: JCI INSIGHT. 2016;1(7):85375

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

Yang H; Wang H; Levine YA; Gunasekaran MK; Wang Y; Addorisio M; Zhu S; Li W; Li J; de Kleijn DP; Olofsson PS; Warren HS; He M; Al-Abed Y; Roth J; Antoine DJ; Chavan SS; Andersson U; Tracey KJ
Article: BIOELECTRONIC MEDICINE. 2016;3:18-28

Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes.

Hanes WM; Olofsson PS; Talbot S; Tsaava T; Ochani M; Imperato GH; Levine YA; Roth J; Pascal MA; Foster SL; Wang P; Woolf C; Chavan SS; Tracey KJ
Journal article: BIOELECTRONIC MEDICINE. 2015;2(1):37-42

Single-Pulse and Unidirectional Electrical Activation of the Cervical Vagus Nerve Reduces Tumor Necrosis Factor in Endotoxemia

Olofsson PS; Levine YA; Caravaca A; Chavan SS; Pavlov VA; Faltys M; Tracey KJ
Journal article: JOURNAL OF IMMUNOLOGY. 2015;194(1_Supplement):197.2

Neuronal circuits modulate antigen flow through lymph nodes (IRC11P.420)

Hanes W; Olofsson P; Tsaava T; Levine Y; Chavan S; Tracey K
Article: MOLECULAR MEDICINE. 2014;20(1):350-358

α7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release.

Lu B; Kwan K; Levine YA; Olofsson PS; Yang H; Li J; Joshi S; Wang H; Andersson U; Chavan SS; Tracey KJ
Journal article: BIOELECTRONIC MEDICINE. 2014;1(1):34-43

Neurostimulation of the Cholinergic Antiinflammatory Pathway in Rheumatoid Arthritis and Inflammatory Bowel Disease

Levine YA; Koopman F; Faltys M; Zitnik R; Tak P-P
Article: PLOS ONE. 2014;9(8):e103992

Sequestering HMGB1 via DNA-conjugated beads ameliorates murine colitis.

Ju Z; Chavan SS; Antoine DJ; Dancho M; Tsaava T; Li J; Lu B; Levine YA; Stiegler A; Tamari Y; Al-Abed Y; Roth J; Tracey KJ; Yang H
Article: PLOS ONE. 2014;9(8):e104530

Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis.

Levine YA; Koopman FA; Faltys M; Caravaca A; Bendele A; Zitnik R; Vervoordeldonk MJ; Tak PP
Article: JOURNAL OF INTERNAL MEDICINE. 2013;274(4):381-390

HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors.

Valdés-Ferrer SI; Rosas-Ballina M; Olofsson PS; Lu B; Dancho ME; Ochani M; Li JH; Scheinerman JA; Katz DA; Levine YA; Hudson LK; Yang H; Pavlov VA; Roth J; Blanc L; Antoine DJ; Chavan SS; Andersson U; Diamond B; Tracey KJ
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(Suppl 3):a245

THU0237 First-in-Human Study of Vagus Nerve Stimulation for Rheumatoid Arthritis: Clinical and Biomarker Results Through Day 84

Koopman F; Miljko S; Grazio S; Sokolovic S; Tracey K; Levine Y; Zitnik R; Tak P-P
Journal article: GASTROENTEROLOGY. 2013;144(5):s-67

322 Vagus Nerve Stimulation Provides Prolonged and Spleen-Independent Protection Against Indomethacin-Induced Intestinal Inflammation

Levine YA; Caravaca A; Faltys M; Arnold A; Zitnik R
Journal article: INFLAMMATORY BOWEL DISEASES. 2012;18:s92

Vagus Nerve Stimulation Reduces Inflammation of the Small Intestinal Mucosa in the Indomethacin-Induced Enteropathy Model

Levine Y; Caravaca A; Faltys M; Arnold A; Zitnik R
Article: MOLECULAR MEDICINE. 2012;18(1):539-543

α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.

Olofsson PS; Katz DA; Rosas-Ballina M; Levine YA; Ochani M; Valdés-Ferrer SI; Pavlov VA; Tracey KJ; Chavan SS
Article: SCIENCE. 2011;334(6052):98-101

Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.

Rosas-Ballina M; Olofsson PS; Ochani M; Valdés-Ferrer SI; Levine YA; Reardon C; Tusche MW; Pavlov VA; Andersson U; Chavan S; Mak TW; Tracey KJ
Journal article: JOURNAL OF IMMUNOLOGY. 2011;186(1_Supplement):116.37

alpha7 nicotinic acetylcholine receptor and cAMP response element binding protein are essential for prolonged monocyte deactivation by vagus nerve signaling (116.37)

Olofsson LP; Tusche M; Reardon C; Rosas-Ballina M; Parrish W; Levine Y; Gregersen P; Diamond B; Chavan S; Mak T; Tracey K
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2004;289(1-2):211-223

Recombinant HMGB1 with cytokine-stimulating activity.

Li J; Wang H; Mason JM; Levine J; Yu M; Ulloa L; Czura CJ; Tracey KJ; Yang H
Article: LIFE SUPPORT & BIOSPHERE SCIENCE : INTERNATIONAL JOURNAL OF EARTH SPACE. 2003;9(1-2):17-30

Work measurement for estimating food preparation time of a bioregenerative diet.

Olabi A; Hunter J; Jackson P; Segal M; Spies R; Wang C; Lau C; Ong C; Alexander C; Raskob E; Plichta J; Zeira O; Rivera R; Wang S; Pottle B; Leung C; Vicens C; Tao C; Beers C; Fung G; Levine J; Yoo J; Jackson J; Saikkonen K; Zimmerman M; Cunningham M; Crum M; Ishman N; Voo N; Cadena R; Relinger R; Wada S
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Conference publication: 2023;:714

POS0834 LONG-TERM EXTENSION STUDY OF THE SAFETY AND EFFICACY OF NEUROIMMUNE MODULATION USING A VAGUS NERVE STIMULATION DEVICE IN PATIENTS WITH RHEUMATOID ARTHRITIS

Gaylis N; Sikes D; Kivitz A; Horowitz DM; Evangelista M; Levine Y; Chernoff D; Genovese MC
Review: INTERNATIONAL IMMUNOLOGY. 2021;33(6):349-356

The brain-gut axis, inflammatory bowel disease and bioelectronic medicine.

Eberhardson M; Levine YA; Tarnawski L; Olofsson PS
Conference publication: 2019;:264.1-26264

LB0009 FIRST-IN-HUMAN STUDY OF NOVEL IMPLANTED VAGUS NERVE STIMULATION DEVICE TO TREAT RHEUMATOID ARTHRITIS

Genovese MC; Gaylis N; Sikes D; Kivitz A; Horowitz DM; Peterfy C; Levine Y; Chernoff D
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;89(3):e12745

Towards improved control of inflammatory bowel disease.

Eberhardson M; Hedin CRH; Carlson M; Tarnawski L; Levine YA; Olofsson PS
Review: FRONTIERS IN NEUROSCIENCE. 2019;13:911

Vagus Nerve Stimulation in Rodent Models: An Overview of Technical Considerations.

Noller CM; Levine YA; Urakov TM; Aronson JP; Nash MS
Corrigendum: JCI INSIGHT. 2018;3(24):126617

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

Yang H; Wang H; Levine YA; Gunasekaran MK; Wang Y; Addorisio M; Zhu S; Li W; Li J; de Kleijn DP; Olofsson PS; Warren HS; He M; Al-Abed Y; Roth J; Antoine DJ; Chavan SS; Andersson U; Tracey KJ
Other: JCI INSIGHT. 2018;3(24):126616

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

Yang H; Wang H; Levine YA; Gunasekaran MK; Wang Y; Addorisio M; Zhu S; Li W; Li J; de Kleijn DP; Olofsson PS; Warren HS; He M; Al-Abed Y; Roth J; Antoine DJ; Chavan SS; Andersson U; Tracey KJ
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(Suppl 2):981

SAT0240 Vagus nerve stimulation in patients with rheumatoid arthritis: two-year safety and efficacy

Koopman FA; Musters A; Backer MJ; Gerlag D; Miljko S; Grazio S; Sokolovic S; Levine YA; Chernoff D; de Vries N; Tak P-P
Book chapter: NEUROMODULATION. 2018;p. xi-xiii

List of Contributors of Volume 3

Abell T; Abraham WT; Alabbad A; Al-Kaisy A; Andréll P; McKinley RA; Angeli CA; Ardell JL; Arnold A; Audu M; Baker KB; Barolat G; Baskin JZ; Benderro GF; Bennett ME; Bikson M; Bouton CE; Buckley U; Carvalho S; Cavuoto J; Chae J; Chen JDZ; Chen S; Cohn JA; Creasey GH; Czura CJ; Damato EG; de Groat WC; Decker MJ; DiMarco AF; Dipietro L; Dmochowski RR; Dorman MF; Duarte RV; Durand DM; Germany RE; Emala C; Errico JP; Faltys M; Franke M; Fregni F; French M; Fritz JR; Gassler JP; Calle AG; Harkema SJ; Hassouna M; Horsch S; Humayun MS; Huston JM; Jin H; Kapural L; Kaufman MR; Kilgore KL; Knutson JS; Kobetic R; Kowalski KE; Kowalik CG; Krames ES; Leite J; Levine YA; Li Y; Loudin J; Lu PL; Machado AG; Makowski NS; Malde S; Ackermann DM; Milam DF; Mogilner AY; Mousa HM; Moynahan M; Murray D; Olofsson PS; Onders RP; Peckham PH; Perryman L; Piedemonte F; Prager JP; Rejc E; Reynolds WS; Sahai A; Salavatian S; Schiefer MA; Schneider M; Schulte S; Selkirk S; Simis M; Simon B; Simon J; Snyder J; Staats P; Strohl KP; Thibaut A; Thomson SJ; Triolo RJ; Tyler DJ; Unal G; Vasquez A; Wagner T; Wathen CA; Weiland JD; Wilson BS; Wilson RD; Yao S; Yin J; Yoruk A; Zitnik R
Conference publication: JOURNAL OF CROHNS & COLITIS. 2018;12:S397-S398

The effects of vagus nerve stimulation in biologic-refractory Crohn's disease: A prospective clinical trial

D'Haens G; Cabrijan Z; Eberhardson M; van den Bergh R; Lowenberg M; Fiorino G; Danese S; Levine Y; Chernoff D
Book chapter: NEUROMODULATION. 2018;p. 1503-1511

Chapter 127 Bioelectronic Therapy for the Treatment of Rheumatoid Arthritis and Inflammatory Bowel Disease

Levine YA; Simon J; Faltys M; Zitnik R
Book chapter: NEUROMODULATION. 2018;p. 1493-1502

Chapter 126 Activation of the Inflammatory Reflex in Rheumatoid Arthritis and Inflammatory Bowel Disease; Preclinical Evidence

Levine YA; Faltys M; Zitnik R
Book chapter: NEUROMODULATION. 2018;p. 1651-1663

Chapter 140 Perspectives on the Issues and Barriers to Starting a New Neuromodulation Company From New Start-Ups in Neuromodulation

Krames ES; Snyder J; Arnold A; Levine YA; Bennett ME; Perryman L
Book chapter: ELECTROCEUTICALS. 2017;p. 35-53

VNS for Treatment of Inflammatory Joint Diseases

Levine YA; Simon JM; Koopman F; Faltys M; Zitnik R; Tak P-P
Corrigendum: SHOCK. 2014;41(3):266

HMGB1 Mediates Persistent Splenocyte Priming In Sepsis Survivors: Evidence From A Murine Model (vol 40, pg 492, 2013)

Valdes-Ferrer SI; Rosas-Ballina M; Olofsson PS; Lu B; Dancho ME; Ochani M; Li JH; Scheinerman JA; Katz DA; Levine YA
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:116.10

Cholinergic neuronal signals attenuate inflammasome activation through inhibiting mitochondrial stress

Lu B; Levine Y; Yang H; Kwan K; Olofsson P; Andersson U; Chavan S; Tracey K
Conference publication: SHOCK. 2013;39:20

CHOLINERGIC NEURONAL SIGNALS ATTENUATE INFLAMMASOME ACTIVATION THROUGH INHIBITING MITOCHONDRIAL STRESS

Lu B; Levine Y; Kwan K; Yang H; Olofsson PS; Andersson U; Chavan SS; Tracey K
Review: IMMUNOLOGICAL REVIEWS. 2012;248(1):188-204

Rethinking inflammation: neural circuits in the regulation of immunity.

Olofsson PS; Rosas-Ballina M; Levine YA; Tracey KJ
Editorial comment: ARTHRITIS & RHEUMATOLOGY. 2008;58(9):2919-2921

Spinal p38 MAP kinase regulates peripheral cholinergic outflow.

Waldburger J-M; Boyle DL; Edgar M; Sorkin LS; Levine YA; Pavlov VA; Tracey K; Firestein GS

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