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Yuan Jiang

PhD Student

Research description

I am a PhD student in Ingrid Kockum's research group, mainly under Xia Jiang's supervision. In my PhD project, I bend my efforts to genetic epidemiology. The title of my research project is "Using larger-scale genetic data and complied analytical strategy to understand the etiology and sex disparity of multiple sclerosis". I use extensive genetic information, as well as publicly available Genome-Wide Association Study summary statistics on modifiable environmental exposures, to assess a putative causal relationship and shared genetic component between risk factors and multiple sclerosis (MS).

Currently, I'm mainly involved in the following projects:

  1.  Understand the role of hormonal exposure and risk of multiple sclerosis - a population-based approach and a genome-wide cross-trait analysis (polycystic ovarian syndrome, sex hormones, and risk of MS)
  2. A genome-wide cross-trait analysis between modifiable lifestyle factors and multiple sclerosis (obesity and MS, body mass index, waist-to-hip ratio)
  3. A genome-wide cross-trait analysis between nutritional exposure and multiple sclerosis (vitamin D and MS)
  4.  A genome-wide cross-trait analysis between multiple sclerosis and its neurological comorbidities (depression, anxiety, and MS)

Selected publications:

1.Jiang, Y., Dou, Y., Chen, H. et al. Performance of waist-to-height ratio as a screening tool for identifying cardiometabolic risk in children: a meta-analysis. Diabetol Metab Syndr 13, 66 (2021). https://doi.org/10.1186/s13098-021-00688-7 (first co-author)

2.Han J, Jiang Y, Huang J, et al. Postnatal growth of preterm infants during the first two years of life: catch-up growth accompanied by risk of overweight. Ital J Pediatr. 2021;47(1):66. Published 2021 Mar 16. doi:10.1186/s13052-021-01019-2  (first co-author)

3.Dou Y, Jiang Y, Yan Y, Chen H, Zhang Y, Chen X, Wang Y, Cheng H, Zhao X, Hou D, Mi J, Yan W. Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China. BMJ Open 2020;10:e037040. doi:10.1136/ bmjopen-2020-037040  (first co-author)

4.Jiang Y, Dou YL, Xiong F, Zhang L, Zhu GH, Wu T, Zhang Y, Yan WL. Waist-to-height ratio remains an accurate and practical way of identifying cardiometabolic risks in children and adolescents [published online ahead of print, 2018 Mar 22]. Acta Paediatr. 2018;10.1111/apa.14323. doi:10.1111/apa.14323 (first co-author)

5.Mengru Li, Xitaotian Chen, Yi Zhang, Hongyan Chen, Dingmei Wang, Chao Cao, Yuan Jiang, Xiangyuan Huang, Yalan Dou, Yin Wang, Xiaojing Ma, Wei Sheng, Weili Yan, Guoying Huang, the Birth Defect Prevention Group, Red Blood Cell Folate and Serum Folate, Vitamin B-12, and Homocysteine in Chinese Couples Pre-Pregnancy in the SPCC, The Journal of Nutrition, 2022;, nxac050, https://doi.org/10.1093/jn/nxac050

6.Han, J., Zhang, L., Li, S., Zhang, Y., Jiang, Y., Chen, X., ... & Yan, W. (2022). Associations of early nutrition with growth and body composition in very preterm infants: a prospective cohort study. European Journal of Clinical Nutrition76(1), 103-110.

7.Chen, X., Chen, H., Zhang, Y., Jiang, Y., Wang, Y., Huang, X., ... & Yan, W. (2022). Maternal liver dysfunction in early pregnancy predisposes to gestational diabetes mellitus independent of preconception overweight: A prospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology.

8.He W, Wang L, Zhang Y, Jiang Y, Chen X, Wang Y, Dou Y, Chen H, Yan W. Higher Serum Bilirubin Levels in Response to Higher Carbohydrate Intake During Early Pregnancy and Lower Gestational Diabetes Mellitus Occurrence in Overweight and Obese Gravidae. Front Nutr. 2021 Aug 30;8:701422. doi: 10.3389/fnut.2021.701422. PMID: 34527687; PMCID: PMC8435579.

9.Chen, X., Zhang, Y., Chen, H., Jiang, Y., Wang, Y., Wang, D., ... & Yan, W. (2021). Association of maternal folate and vitamin B12 in early pregnancy with gestational diabetes mellitus: a prospective cohort study. Diabetes Care, 44(1), 217-223.

10.Huang X, Ye Y, Li Y, Zhang Y, Zhang Y, Jiang Y, Chen X, Wang L, Yan W. Maternal folate levels during pregnancy and children's neuropsychological development at 2 years of age [published online ahead of print, 2020 Apr 2]. Eur J Clin Nutr. 2020;10.1038/s41430-020-0612-9. doi:10.1038/s41430-020-0612-9

11.Zhou Y, Ye Z, Wang Y, Zhang Y, Tang Z, Yan W, Jiang Y, Huang Y. Comparison of four different regimens against Helicobacter pylori as a first-line treatment: A prospective, cross-sectional, comparative, open trial in Chinese children. Helicobacter. 2020 Apr;25(2):e12679. doi: 10.1111/hel.12679.

12.Ye Y, Dou LM, Zhang Y, Dou YL, Zhao PP, Jiang Y, Gao W, Ji M, He LF, Niu DY, Zhang L, Gao XH, Li Y, Xiao LP, Huang J, Zhang XH, Wang LH, Yan WL. Maternal periconceptional folate status and infant atopic dermatitis: A prospective cohort study [published online ahead of print, 2020 Jul 14]. Pediatr Allergy Immunol. 2020;e13321. doi:10.1111/pai.13321

13.Li M, Zhang Y, Chen X, Wang D, Ji M, Jiang Y, Dou Y, Ma X, Sheng W, Yan W, Huang G.Effectiveness of community-based folate-oriented tertiary interventions on incidence of fetus and birth defects: a protocol for a single-blind cluster randomized controlled trial. BMC Pregnancy Childbirth. 2020;20(1):475. Published 2020 Aug 20. doi:10.1186/s12884-020-03154-w

14.Wang, D. M., Zhang, Y., Jiang, Y., Ying, Y. E., Huang, X. Y., Li, M. R., ... & Group, S. P. C. (2020). Folic Acid Supplementation in Chinese Periconceptional Population: Results from the SPCC Study. Biomedical and Environmental Sciences, 33(8), 557-565.

15.Zhao M, Mill JG, Yan WL, Hong YM, Skidmore P, Stoner L, Mora-Urda AI, Khadilkar A, Alvim RO, Kim HS, Montero López P, Zhang Y, Saeedi P, Zaniqueli D, Jiang Y, Oliosa PR, de Faria ER, Mu K, Niu DY, Magnussen CG, Xi B. Static cut-points of hypertension and increased arterial stiffness in children and adolescents: The International Childhood Vascular Function Evaluation Consortium. J Clin Hypertens (Greenwich). 2019;21(9):1335-1342. doi:10.1111/jch.13642

16. Yan W, Zhang Y, Wang L, Yang W, Li C, Wang L, Gu P, Xia Y, Yan J, Shen Y, Zhao Q, Niu D, Mu K, Jiang Y. Maternal dietary glycaemic change during gestation influences insulin-related gene methylation in the placental tissue: a genome-wide methylation analysis. Genes Nutr. 2019;14:17. Published 2019 May 9. doi:10.1186/s12263-019-0634-x

Book

Jiang Yuan, Yan Weili, redefinition of survival analysis outcome based on patient treatment data, Crazy Statistics, Central South University Press, 2018 ISBN:9787548731962.

 

Research Supports:

20194Y0209                          

Yuan Jiang (PI)                                      

01/01/2020-12/30/2022

Special clinical research project of Shanghai Health Commission

A randomized controlled trial of intermittent caloric restriction (ICR) in adolescents with a high risk of cardiometabolic and the relationship among health effects, intestinal microbiota structure changes, and metabonomics

In this study, a randomized controlled intervention experiment has been conducted in 10-30-year-old people with cardiovascular disease risk. The intervention measure is intermittent caloric restriction (ICR). The duration of this intervention is for two weeks. The primary purpose of this study is to explore the health effects of ICR and explore its mechanism from the aspects of intestinal microbiota and metabolomics.

 

R01ES029945-01A1                         

Junfeng Zhang (PI)                                      

05/01/2019-05/01/2023

NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

Impact of preconception and onward exposure to air pollution on growth trajectories of infants and children

The purpose of this study is to explore the effects of parental exposure to PM10, PM2.5, and ozone before and during pregnancy on the height and weight growth trajectory of their offspring aged 0-2 years.

Role: co-investigator

 

 

17ZDKF1011                          

Yuan Jiang (PI)                                      

07/01/2017-12/30/2021

Key Laboratory Open Project in 2017

Feasibility study on a randomized cluster sampling intervention of comprehensive prevention and intervention strategy for cleft lip and palate

In this study, qualitative interviews and questionnaire-based surveys have been conducted to investigate the feasibility of multi-center RCTs in six hospitals in Shanghai for the prevention and intervention of cleft lip and palate.

 

2017YFC0908105                         

Qiang Xia (PI)                                      

06/01/2017-06/01/2021

The key research program of the Ministry of science and technology of China

A large cohort study on clinical and community population of liver cancer/liver disease

The purpose of this study is to establish a multi-center and large-scale liver diseases and liver cancer database covering multiple liver diseases and multi-population sources. Biological sample information is also recorded to provide support for future precision medicine research.

Role: co-investigator

 

2016YFC1000500                         

Guo-ying Huang (PI)                                      

07/01/2016-06/30/2021

National Key Research and Development Project of China

Causes, mechanisms, and early intervention of significant birth defects in the Chinese population

The aim of this study is to explore the risk factors of significant birth defects, including congenital heart defects, neural tube defects, and inherited mental retardation. We also aim to elucidate its pathogenesis. On this basis, we try to establish an early intervention system for congenital malformation.

Role: co-investigator

 

81560539                                                                                                                       

Jianghong Dai (PI)

01/01/2016---12/30/2019

National Natural Science Foundation of China

The effect of co-infection with hepatitis B virus (HBV) on human papillomavirus (HPV) persistent infection in Men who have Sex with Men                                                          

The purpose of this study was to discuss the effect of HBV on the HPV persistent infection in the population of Men who have Sex with Men.

Role: co-investigator

 

GWIV-24                                        

Guo-ying Huang (PI)                                     

01/01/2015-12/31/2018

The 4th Three-year Action Plan of Shanghai Municipal Public Health Projects

The preconception of key nutrients and the primary prevention of congenital heart disease

The objective of this project was to clarify the relationship between key nutrients before and during pregnancy and congenital heart disease.

Role: co-investigator

 

81260440                                                                                                                       

Jianghong Dai (PI)

01/01/2014---12/30/2016

Natural Science Foundation of Xinjiang

Study on the relation between Occult HBV InfectionOBIwith low or no response to the hepatitis B (HBV) vaccine injection                                                          

In this study, an experiment-based survey was conducted to explore the relationship between the hepatitis B vaccine and low OBI no response.

Role: co-investigator

 

2012ZX10001-007                                                                                               

Ailong Huang (PI)                                 

01/01/2013---09/30/2016

National Twelfth Five major science and technology subjects

Antiviral agents Tenofovir for prevention of emerging HIV infections among MSM population: an open, randomized, multi-center, paralleled controlled trial

The purpose of this intervention study was to evaluate the efficacy and safety of oral Tenofovir before and after exposure (sexual behavior) among HIV-negative men who have sex with men in Western China.

Role: co-investigator

 

Education

  • 09/2013-06/2016 Master Degree in Epidemiology and Health Statistics, Xinjiang Medical University, China

Title of master thesis: Analysis of influencing factors of HIV prevention among the population of Men who have Sex with Men

  • 09/2009-06/2013 Bachelor Degree in Preventive Medicine, Xinjiang Medical University, China

Title of bachelor thesis: Comparison of Oscillographic electronic sphygmomanometer and mercury stethoscope sphygmomanometer in children and adolescents aged 7-17 years in Shanghai

Academic honours, awards and prizes

2013  National Endeavor Scholarship

2014 Outstanding paper of the Chinese Preventive Medicine Association Epidemiology Branch Meeting

2014  Master Degree Scholarship

2015  The second-class prize of National Statistical Modeling Contest

2015  National scholarship for master degree

2017  The first-class prize of Papers Community in Maternal and Health Care in Shanghai Maternal-Child Health Centers