Yvonne Freund-Levi

Publications
Grants
CV
Public outreach and news

Articles

Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S14)

Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer’s disease in the EMIF‐AD Multimodal Biomarker Discovery study

Smith RG; Imm JL; Dobricic V; Sommerer Y; Bos I; Vos SJB; Verhey FRJ; Scheltens P; Engelborgs S; Frisoni GB; Blin O; Richardson JC; Bordet R; Tsolaki M; Popp J; Martinez‐Lage P; Lleo A; Johannsen P; Freund‐Levi Y; Lutz F; Vandenberghe R; Wittig M; Frank A; Lovestone S; Streffer J; Andreasson U; Blennow K; Visser PJ; Zetterberg H; Bertram L; Lunnon K
Article: ALZHEIMERS & DEMENTIA. 2023;19(6):2317-2331

Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits.

Küçükali F; Neumann A; Van Dongen J; De Pooter T; Joris G; De Rijk P; Ohlei O; Dobricic V; Bos I; Vos SJB; Engelborghs S; De Roeck E; Vandenberghe R; Gabel S; Meersmans K; Tsolaki M; Verhey F; Martinez-Lage P; Tainta M; Frisoni G; Blin O; Richardson JC; Bordet R; Alzheimer's Disease Neuroimaging Initiative (ADNI); Scheltens P; Popp J; Peyratout G; Johannsen P; Frölich L; Freund-Levi Y; Streffer J; Lovestone S; Legido-Quigley C; Kate MT; Barkhof F; Zetterberg H; Bertram L; Strazisar M; Visser PJ; Van Broeckhoven C; Sleegers K; EMIF-AD Study Group
Article: JOURNAL OF NEUROENDOCRINOLOGY. 2023;35(5):e13272

Higher CSF/serum free-T4 ratio is associated with improvement of quality of life during treatment with L-thyroxine.

Funkquist A; Wandt B; Blennow K; Zetterberg H; Svensson J; Bjellerup P; Freund-Levi Y; Sjöberg S
Article: JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE. 2023;10(2):207-211

The Geras Solutions Cognitive Test for Assessing Cognitive Impairment: Normative Data from a Population-Based Cohort.

Bloniecki V; Ulfvarson J; Javanshiri K; Hagman G; Freund-Levi Y; Nordström A
Article: BMJ OPEN. 2022;12(11):e066834

Swedish Chronic Pain Biobank: protocol for a multicentre registry and biomarker project.

Ghafouri B; Ernberg M; Andréll P; Bäckryd E; Fisher MR; Freund-Levi Y; Grelz H; Gräbel O; Karlsten R; Kosek E; Löfgren M; Ringqvist Å; Rudling K; Stålnacke B-M; Sörlén N; Uhlin K; Westergren H; Gerdle B
Article: ALZHEIMERS & DEMENTIA. 2022;18(10):1832-1845

Characteristics of subjective cognitive decline associated with amyloid positivity.

Janssen O; Jansen WJ; Vos SJB; Boada M; Parnetti L; Gabryelewicz T; Fladby T; Molinuevo JL; Villeneuve S; Hort J; Epelbaum S; Lleó A; Engelborghs S; van der Flier WM; Landau S; Popp J; Wallin A; Scheltens P; Rikkert MO; Snyder PJ; Rowe C; Chételat G; Ruíz A; Marquié M; Chipi E; Wolfsgruber S; Heneka M; Boecker H; Peters O; Jarholm J; Rami L; Tort-Merino A; Binette AP; Poirier J; Rosa-Neto P; Cerman J; Dubois B; Teichmann M; Alcolea D; Fortea J; Sánchez-Saudinós MB; Ebenau J; Pocnet C; Eckerström M; Thompson L; Villemagne V; Buckley R; Burnham S; Delarue M; Freund-Levi Y; Wallin ÅK; Ramakers I; Tsolaki M; Soininen H; Hampel H; Spiru L; Alzheimer's Disease Neuroimaging Initiative; FACEHBI study group; PREVENT-AD research group; Tijms B; Ossenkoppele R; Verhey FRJ; Jessen F; Visser PJ
Article: ALZHEIMERS & DEMENTIA. 2022;:807-820

Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology.

Delvenne A; Gobom J; Tijms B; Bos I; Reus LM; Dobricic V; Kate MT; Verhey F; Ramakers I; Scheltens P; Teunissen CE; Vandenberghe R; Schaeverbeke J; Gabel S; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Tsolaki M; Freund-Levi Y; Lovestone S; Streffer J; Barkhof F; Bertram L; Blennow K; Zetterberg H; Visser PJ; Vos SJB
Article: MOLECULAR PSYCHIATRY. 2022;27(4):1990-1999

Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation.

Neumann A; Küçükali F; Bos I; Vos SJB; Engelborghs S; De Pooter T; Joris G; De Rijk P; De Roeck E; Tsolaki M; Verhey F; Martinez-Lage P; Tainta M; Frisoni G; Blin O; Richardson J; Bordet R; Scheltens P; Popp J; Peyratout G; Johannsen P; Frölich L; Vandenberghe R; Freund-Levi Y; Streffer J; Lovestone S; Legido-Quigley C; Ten Kate M; Barkhof F; Strazisar M; Zetterberg H; Bertram L; Visser PJ; van Broeckhoven C; Sleegers K; EMIF-AD study group
Article: MOLECULAR NEURODEGENERATION. 2022;17(1):27

Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.

Visser PJ; Reus LM; Gobom J; Jansen I; Dicks E; van der Lee SJ; Tsolaki M; Verhey FRJ; Popp J; Martinez-Lage P; Vandenberghe R; Lleó A; Molinuevo JL; Engelborghs S; Freund-Levi Y; Froelich L; Sleegers K; Dobricic V; Lovestone S; Streffer J; Vos SJB; Bos I; ADNI; Smit AB; Blennow K; Scheltens P; Teunissen CE; Bertram L; Zetterberg H; Tijms BM
Article: JAMA NEUROLOGY. 2022;79(3):228-243

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.

Jansen WJ; Janssen O; Tijms BM; Vos SJB; Ossenkoppele R; Visser PJ; Amyloid Biomarker Study Group; Aarsland D; Alcolea D; Altomare D; von Arnim C; Baiardi S; Baldeiras I; Barthel H; Bateman RJ; Van Berckel B; Binette AP; Blennow K; Boada M; Boecker H; Bottlaender M; den Braber A; Brooks DJ; Van Buchem MA; Camus V; Carill JM; Cerman J; Chen K; Chételat G; Chipi E; Cohen AD; Daniels A; Delarue M; Didic M; Drzezga A; Dubois B; Eckerström M; Ekblad LL; Engelborghs S; Epelbaum S; Fagan AM; Fan Y; Fladby T; Fleisher AS; Van der Flier WM; Förster S; Fortea J; Frederiksen KS; Freund-Levi Y; Frings L; Frisoni GB; Fröhlich L; Gabryelewicz T; Gertz H-J; Gill KD; Gkatzima O; Gómez-Tortosa E; Grimmer T; Guedj E; Habeck CG; Hampel H; Handels R; Hansson O; Hausner L; Hellwig S; Heneka MT; Herukka S-K; Hildebrandt H; Hodges J; Hort J; Huang C-C; Iriondo AJ; Itoh Y; Ivanoiu A; Jagust WJ; Jessen F; Johannsen P; Johnson KA; Kandimalla R; Kapaki EN; Kern S; Kilander L; Klimkowicz-Mrowiec A; Klunk WE; Koglin N; Kornhuber J; Kramberger MG; Kuo H-C; Van Laere K; Landau SM; Landeau B; Lee DY; de Leon M; Leyton CE; Lin K-J; Lleó A; Löwenmark M; Madsen K; Maier W; Marcusson J; Marquié M; Martinez-Lage P; Maserejian N; Mattsson N; de Mendonça A; Meyer PT; Miller BL; Minatani S; Mintun MA; Mok VCT; Molinuevo JL; Morbelli SD; Morris JC; Mroczko B; Na DL; Newberg A; Nobili F; Nordberg A; Olde Rikkert MGM; de Oliveira CR; Olivieri P; Orellana A; Paraskevas G; Parchi P; Pardini M; Parnetti L; Peters O; Poirier J; Popp J; Prabhakar S; Rabinovici GD; Ramakers IH; Rami L; Reiman EM; Rinne JO; Rodrigue KM; Rodríguez-Rodriguez E; Roe CM; Rosa-Neto P; Rosen HJ; Rot U; Rowe CC; Rüther E; Ruiz A; Sabri O; Sakhardande J; Sánchez-Juan P; Sando SB; Santana I; Sarazin M; Scheltens P; Schröder J; Selnes P; Seo SW; Silva D; Skoog I; Snyder PJ; Soininen H; Sollberger M; Sperling RA; Spiru L; Stern Y; Stomrud E; Takeda A; Teichmann M; Teunissen CE; Thompson LI; Tomassen J; Tsolaki M; Vandenberghe R; Verbeek MM; Verhey FRJ; Villemagne V; Villeneuve S; Vogelgsang J; Waldemar G; Wallin A; Wallin ÅK; Wiltfang J; Wolk DA; Yen T-C; Zboch M; Zetterberg H
Article: JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES. 2022;34(3):214-223

Neuropsychiatric Symptoms in Dementia: Considering a Clinical Role for Electroencephalography.

Holmgren S; Andersson T; Berglund A; Aarsland D; Cummings J; Freund-Levi Y
Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2022;14(1):e12286

Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition.

Wesenhagen KEJ; Gobom J; Bos I; Vos SJB; Martinez-Lage P; Popp J; Tsolaki M; Vandenberghe R; Freund-Levi Y; Verhey F; Lovestone S; Streffer J; Dobricic V; Bertram L; Alzheimer's Disease Neuroimaging Initiative; Blennow K; Pikkarainen M; Hallikainen M; Kuusisto J; Laakso M; Soininen H; Scheltens P; Zetterberg H; Teunissen CE; Visser PJ; Tijms BM
Article: BIOMEDICINES. 2021;9(11):1610

Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort.

Xu J; Green R; Kim M; Lord J; Ebshiana A; Westwood S; Baird AL; Nevado-Holgado AJ; Shi L; Hye A; Snowden SG; Bos I; Vos SJB; Vandenberghe R; Teunissen CE; Kate MT; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck EE; Engelborghs S; Sleegers K; Bordet R; Rami L; Kettunen P; Tsolaki M; Verhey FRJ; Alcolea D; Lleó A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Proitsi P; Legido-Quigley C; On Behalf Of The European Medical Information Fram
Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;83(3):1291-1301

Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study.

Tofiq A; Zetterberg H; Blennow K; Basun H; Cederholm T; Eriksdotter M; Faxén-Irving G; Hjorth E; Jernerén F; Schultzberg M; Wahlund L-O; Palmblad J; Freund-Levi Y
Article: ALZHEIMERS & DEMENTIA. 2021;17(9):1452-1464

Replication study of plasma proteins relating to Alzheimer's pathology.

Shi L; Winchester LM; Westwood S; Baird AL; Anand SN; Buckley NJ; Hye A; Ashton NJ; Bos I; Vos SJB; Kate MT; Scheltens P; Teunissen CE; Vandenberghe R; Gabel S; Meersmans K; Engelborghs S; De Roeck EE; Sleegers K; Frisoni GB; Blin O; Richardson JC; Bordet R; Molinuevo JL; Rami L; Wallin A; Kettunen P; Tsolaki M; Verhey F; Lléo A; Sala I; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Legido-Quigley C; Barkhof F; Andreasson U; Blennow K; Zetterberg H; Streffer J; Lill CM; Bertram L; Visser PJ; Kolb HC; Narayan VA; Lovestone S; Nevado-Holgado AJ
Article: PROTEOMES. 2021;9(3):36

CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals.

Tijms BM; Gobom J; Teunissen C; Dobricic V; Tsolaki M; Verhey F; Popp J; Martinez-Lage P; Vandenberghe R; Lleó A; Molinuévo JL; Engelborghs S; Freund-Levi Y; Froelich L; Bertram L; Lovestone S; Streffer J; Vos S; Adni; Blennow K; Scheltens P; Zetterberg H; Visser PJ
Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):64

Research diagnostic criteria for Alzheimer's disease: findings from the LipiDiDiet randomized controlled trial.

Rosenberg A; Solomon A; Soininen H; Visser PJ; Blennow K; Hartmann T; Kivipelto M; LipiDiDiet clinical study group
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S3)

CSF proteomic profiling of mild cognitive impairment individuals with suspected non‐Alzheimer’s disease pathophysiology

Delvenne A; Gobom J; Tijms BM; Bos I; Verhey FR; Ramakers IH; Scheltens P; Teunissen CE; Vandenberghe R; Gabel S; Popp J; Peyratout G; Martinez‐Lage P; Tainta M; Tsolaki M; Freund‐Levi Y; Lovestone S; Streffer J; Blennow K; Zetterberg H; Visser PJ; Vos SJ
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S3)

Synaptic proteins relate to memory scores in preclinical Alzheimer’s disease and cognitively healthy controls depending on amyloid

Wesenhagen KEJ; Visser PJ; Gobom J; Bos I; Vos SJB; Martinez‐Lage P; Tainta M; Popp J; Peyratout G; Tsolaki M; Vandenberghe R; Freund‐Levi Y; Verhey FRJ; Lovestone S; Streffer J; Blennow K; Scheltens P; Teunissen CE; Zetterberg H; Tijms BM; Initiative ADN
Article: ALZHEIMERS RESEARCH & THERAPY. 2020;12(1):153

Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration?

Bloniecki V; Zetterberg H; Aarsland D; Vannini P; Kvartsberg H; Winblad B; Blennow K; Freund-Levi Y
Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;77(3):1353-1368

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology.

Shi L; Winchester LM; Liu BY; Killick R; Ribe EM; Westwood S; Baird AL; Buckley NJ; Hong S; Dobricic V; Kilpert F; Franke A; Kiddle S; Sattlecker M; Dobson R; Cuadrado A; Hye A; Ashton NJ; Morgan AR; Bos I; Vos SJB; Ten Kate M; Scheltens P; Vandenberghe R; Gabel S; Meersmans K; Engelborghs S; De Roeck EE; Sleegers K; Frisoni GB; Blin O; Richardson JC; Bordet R; Molinuevo JL; Rami L; Wallin A; Kettunen P; Tsolaki M; Verhey F; Lleó A; Alcolea D; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Johannsen P; Teunissen CE; Freund-Levi Y; Frölich L; Legido-Quigley C; Barkhof F; Blennow K; Rasmussen KL; Nordestgaard BG; Frikke-Schmidt R; Nielsen SF; Soininen H; Vellas B; Kloszewska I; Mecocci P; Zetterberg H; Morgan BP; Streffer J; Visser PJ; Bertram L; Nevado-Holgado AJ; Lovestone S
Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;74(1):213-225

Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.

Westwood S; Baird AL; Anand SN; Nevado-Holgado AJ; Kormilitzin A; Shi L; Hye A; Ashton NJ; Morgan AR; Bos I; Vos SJB; Baker S; Buckley NJ; Ten Kate M; Scheltens P; Teunissen CE; Vandenberghe R; Gabel S; Meersmans K; Engelborghs S; De Roeck EE; Sleegers K; Frisoni GB; Blin O; Richardson JC; Bordet R; Molinuevo JL; Rami L; Wallin A; Kettunen P; Tsolaki M; Verhey F; Lléo A; Sala I; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Legido-Quigley C; Bertram L; Barkhof F; Zetterberg H; Morgan BP; Streffer J; Visser PJ; Lovestone S
Article: ALZHEIMERS & DEMENTIA. 2019;15(11):1478-1488

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

Shi L; Westwood S; Baird AL; Winchester L; Dobricic V; Kilpert F; Hong S; Franke A; Hye A; Ashton NJ; Morgan AR; Bos I; Vos SJB; Buckley NJ; Kate MT; Scheltens P; Vandenberghe R; Gabel S; Meersmans K; Engelborghs S; De Roeck EE; Sleegers K; Frisoni GB; Blin O; Richardson JC; Bordet R; Molinuevo JL; Rami L; Wallin A; Kettunen P; Tsolaki M; Verhey F; Lleó A; Alcolea D; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Johannsen P; Teunissen CE; Freund-Levi Y; Frölich L; Legido-Quigley C; Barkhof F; Blennow K; Zetterberg H; Baker S; Morgan BP; Streffer J; Visser PJ; Bertram L; Lovestone S; Nevado-Holgado AJ
Article: LANCET NEUROLOGY. 2019;18(11):1034-1044

Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study.

van Maurik IS; Vos SJ; Bos I; Bouwman FH; Teunissen CE; Scheltens P; Barkhof F; Frolich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Rüther E; Nobili F; Frisoni GB; Spiru L; Freund-Levi Y; Wallin AK; Hampel H; Soininen H; Tsolaki M; Verhey F; Kłoszewska I; Mecocci P; Vellas B; Lovestone S; Galluzzi S; Herukka S-K; Santana I; Baldeiras I; de Mendonça A; Silva D; Chetelat G; Egret S; Palmqvist S; Hansson O; Visser PJ; Berkhof J; van der Flier WM; Alzheimer's Disease Neuroimaging Initiative
Article: ALZHEIMERS & DEMENTIA. 2019;15(7):888-898

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.

Vermunt L; Sikkes SAM; van den Hout A; Handels R; Bos I; van der Flier WM; Kern S; Ousset P-J; Maruff P; Skoog I; Verhey FRJ; Freund-Levi Y; Tsolaki M; Wallin ÅK; Olde Rikkert M; Soininen H; Spiru L; Zetterberg H; Blennow K; Scheltens P; Muniz-Terrera G; Visser PJ; Alzheimer Disease Neuroimaging Initiative; AIBL Research Group; ICTUS/DSA study groups
Article: ALZHEIMERS & DEMENTIA. 2019;15(6):817-827

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort.

Kim M; Snowden S; Suvitaival T; Ali A; Merkler DJ; Ahmad T; Westwood S; Baird A; Proitsi P; Nevado-Holgado A; Hye A; Bos I; Vos S; Vandenberghe R; Teunissen C; Ten Kate M; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck E; Sleegers K; Bordet R; Rami L; Kettunen P; Tsolaki M; Verhey F; Sala I; Lléo A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Engelborghs S; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Barkhof F; Ashton N; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Legido-Quigley C
Article: ALZHEIMERS & DEMENTIA. 2019;15(6):742-753

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study.

Lleó A; Alcolea D; Martínez-Lage P; Scheltens P; Parnetti L; Poirier J; Simonsen AH; Verbeek MM; Rosa-Neto P; Slot RER; Tainta M; Izaguirre A; Reijs BLR; Farotti L; Tsolaki M; Vandenbergue R; Freund-Levi Y; Verhey FRJ; Clarimón J; Fortea J; Frolich L; Santana I; Molinuevo JL; Lehmann S; Visser PJ; Teunissen CE; Zetterberg H; Blennow K
Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;69(1):189-197

Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study.

Jernerén F; Cederholm T; Refsum H; Smith AD; Turner C; Palmblad J; Eriksdotter M; Hjorth E; Faxen-Irving G; Wahlund L-O; Schultzberg M; Basun H; Freund-Levi Y
Article: ALZHEIMERS & DEMENTIA. 2019;15(5):644-654

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum.

Bos I; Vos S; Verhey F; Scheltens P; Teunissen C; Engelborghs S; Sleegers K; Frisoni G; Blin O; Richardson JC; Bordet R; Tsolaki M; Popp J; Peyratout G; Martinez-Lage P; Tainta M; Lleó A; Johannsen P; Freund-Levi Y; Frölich L; Vandenberghe R; Westwood S; Dobricic V; Barkhof F; Legido-Quigley C; Bertram L; Lovestone S; Streffer J; Andreasson U; Blennow K; Zetterberg H; Visser PJ
Article: ALZHEIMER'S AND DEMENTIA: TRANSLATIONAL RESEARCH AND CLINICAL INTERVENTIONS. 2019;5:933-938

A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort.

Stamate D; Kim M; Proitsi P; Westwood S; Baird A; Nevado-Holgado A; Hye A; Bos I; Vos SJB; Vandenberghe R; Teunissen CE; Kate MT; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck E; Engelborghs S; Sleegers K; Bordet R; Ramit L; Kettunen P; Tsolaki M; Verhey F; Alcolea D; Lléo A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Legido-Quigley C
Article: ALZHEIMERS & DEMENTIA. 2018;14(7):913-924

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Mattsson N; Groot C; Jansen WJ; Landau SM; Villemagne VL; Engelborghs S; Mintun MM; Lleo A; Molinuevo JL; Jagust WJ; Frisoni GB; Ivanoiu A; Chételat G; Resende de Oliveira C; Rodrigue KM; Kornhuber J; Wallin A; Klimkowicz-Mrowiec A; Kandimalla R; Popp J; Aalten PP; Aarsland D; Alcolea D; Almdahl IS; Baldeiras I; van Buchem MA; Cavedo E; Chen K; Cohen AD; Förster S; Fortea J; Frederiksen KS; Freund-Levi Y; Gill KD; Gkatzima O; Grimmer T; Hampel H; Herukka S-K; Johannsen P; van Laere K; de Leon MJ; Maier W; Marcusson J; Meulenbroek O; Møllergård HM; Morris JC; Mroczko B; Nordlund A; Prabhakar S; Peters O; Rami L; Rodríguez-Rodríguez E; Roe CM; Rüther E; Santana I; Schröder J; Seo SW; Soininen H; Spiru L; Stomrud E; Struyfs H; Teunissen CE; Verhey FRJ; Vos SJB; van Waalwijk van Doorn LJC; Waldemar G; Wallin ÅK; Wiltfang J; Vandenberghe R; Brooks DJ; Fladby T; Rowe CC; Drzezga A; Verbeek MM; Sarazin M; Wolk DA; Fleisher AS; Klunk WE; Na DL; Sánchez-Juan P; Lee DY; Nordberg A; Tsolaki M; Camus V; Rinne JO; Fagan AM; Zetterberg H; Blennow K; Rabinovici GD; Hansson O; van Berckel BNM; van der Flier WM; Scheltens P; Visser PJ; Ossenkoppele R
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_14):p780-p781

P2‐270: INCREASED CSF AMYLOID‐β 1‐38 AND 1‐40 CONCENTRATIONS IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT WITH TAU BUT WITHOUT AMYLOID PATHOPHYSIOLOGY

Vos SJB; Bos I; Verhey FRJ; Engelborghs S; Lleó A; Johannsen P; Freund-Levi Y; Frölich L; Vandenberghe R; Frisoni GB; Blin O; Richardson J; Bordet R; Scheltens P; Ramakers IHGB; Popp J; Tsolaki M; Martinez-Lage P; Bertram L; Lovestone S; Streffer J; Blennow K; Andreasson U; Zetterberg H; Visser PJ
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_3):p201

F1‐02‐01: RELATING CSF MARKERS NEUROGRANIN, NEUROFILAMENT‐LIGHT AND YKL‐40 TO Aβ, APOE ε4 AND COGNITION: RESULTS FROM THE EMIF‐AD MULTIMODAL BIOMARKER DISCOVERY STUDY

Bos I; Vos SJB; Verhey FRJ; Scheltens P; Engelborghs S; Frisoni GB; Blin O; Richardson J; Bordet R; Tsolaki M; Popp J; Martinez-Lage P; Lleó A; Johannsen P; Freund-Levi Y; Frölich L; Vandenberghe R; Baird AL; Barkhof F; Legido-Quigley C; Bertram L; Lovestone S; Streffer J; Andreasson U; Blennow K; Visser PJ; Zetterberg H
Article: FRONTIERS IN AGING NEUROSCIENCE. 2018;10:193

Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data.

Bos I; Vos SJB; Jansen WJ; Vandenberghe R; Gabel S; Estanga A; Ecay-Torres M; Tomassen J; den Braber A; Lleó A; Sala I; Wallin A; Kettunen P; Molinuevo JL; Rami L; Chetelat G; de la Sayette V; Tsolaki M; Freund-Levi Y; Johannsen P; Alzheimer's Disease Neuroimaging Initiative; Novak GP; Ramakers I; Verhey FR; Visser PJ
Article: JAMA PSYCHIATRY. 2018;75(1):84-95

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Jansen WJ; Ossenkoppele R; Tijms BM; Fagan AM; Hansson O; Klunk WE; van der Flier WM; Villemagne VL; Frisoni GB; Fleisher AS; Lleó A; Mintun MA; Wallin A; Engelborghs S; Na DL; Chételat G; Molinuevo JL; Landau SM; Mattsson N; Kornhuber J; Sabri O; Rowe CC; Parnetti L; Popp J; Fladby T; Jagust WJ; Aalten P; Lee DY; Vandenberghe R; Resende de Oliveira C; Kapaki E; Froelich L; Ivanoiu A; Gabryelewicz T; Verbeek MM; Sanchez-Juan P; Hildebrandt H; Camus V; Zboch M; Brooks DJ; Drzezga A; Rinne JO; Newberg A; de Mendonça A; Sarazin M; Rabinovici GD; Madsen K; Kramberger MG; Nordberg A; Mok V; Mroczko B; Wolk DA; Meyer PT; Tsolaki M; Scheltens P; Verhey FRJ; Visser PJ; Amyloid Biomarker Study Group; Aarsland D; Alcolea D; Alexander M; Almdahl IS; Arnold SE; Baldeiras I; Barthel H; van Berckel BNM; Blennow K; van Buchem MA; Cavedo E; Chen K; Chipi E; Cohen AD; Förster S; Fortea J; Frederiksen KS; Freund-Levi Y; Gkatzima O; Gordon MF; Grimmer T; Hampel H; Hausner L; Hellwig S; Herukka S-K; Johannsen P; Klimkowicz-Mrowiec A; Köhler S; Koglin N; van Laere K; de Leon M; Lisetti V; Maier W; Marcusson J; Meulenbroek O; Møllergård HM; Morris JC; Nordlund A; Novak GP; Paraskevas GP; Perera G; Peters O; Ramakers IHGB; Rami L; Rodríguez-Rodríguez E; Roe CM; Rot U; Rüther E; Santana I; Schröder J; Seo SW; Soininen H; Spiru L; Stomrud E; Struyfs H; Teunissen CE; Vos SJB; van Waalwijk van Doorn LJC; Waldemar G; Wallin ÅK; Wiltfang J; Zetterberg H
Article: ALZHEIMERS RESEARCH & THERAPY. 2017;9(1):101

Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline.

Bos I; Verhey FR; Ramakers IHGB; Jacobs HIL; Soininen H; Freund-Levi Y; Hampel H; Tsolaki M; Wallin ÅK; van Buchem MA; Oleksik A; Verbeek MM; Olde Rikkert M; van der Flier WM; Scheltens P; Aalten P; Visser PJ; Vos SJB
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;61(2):515-519

Does Fatty Acid Composition in Subcutaneous Adipose Tissue Differ between Patients with Alzheimer's Disease and Cohabiting Proxies?

Faxen-Irving G; Falahati F; Basun H; Eriksdotter M; Vedin I; Wahlund L-O; Schultzberg M; Hjorth E; Palmblad J; Cederholm T; Freund-Levi Y
Article: LANCET NEUROLOGY. 2017;16(12):965-975

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial.

Soininen H; Solomon A; Visser PJ; Hendrix SB; Blennow K; Kivipelto M; Hartmann T; LipiDiDiet clinical study group
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;60(4):1387-1395

Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study.

Reijs BLR; Vos SJB; Soininen H; Lötjonen J; Koikkalainen J; Pikkarainen M; Hall A; Vanninen R; Liu Y; Herukka S-K; Freund-Levi Y; Frisoni GB; Frölich L; Nobili F; Rikkert MO; Spiru L; Tsolaki M; Wallin ÅK; Scheltens P; Verhey F; Visser PJ
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2017;106(4):1157-1165

DHA-rich n-3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study.

Karimi M; Vedin I; Freund Levi Y; Basun H; Faxén Irving G; Eriksdotter M; Wahlund L-O; Schultzberg M; Hjorth E; Cederholm T; Palmblad J
Article: ALZHEIMERS & DEMENTIA. 2017;13(8):903-912

Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers.

Handels RLH; Vos SJB; Kramberger MG; Jelic V; Blennow K; van Buchem M; van der Flier W; Freund-Levi Y; Hampel H; Olde Rikkert M; Oleksik A; Pirtosek Z; Scheltens P; Soininen H; Teunissen C; Tsolaki M; Wallin AK; Winblad B; Verhey FRJ; Visser PJ
Article: NEUROBIOLOGY OF AGING. 2017;56:33-40

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease.

Bos I; Vos SJ; Frölich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Rüther E; Engelborghs S; Niemantsverdriet E; De Roeck EE; Tsolaki M; Freund-Levi Y; Johannsen P; Vandenberghe R; Lleó A; Alcolea D; Frisoni GB; Galluzzi S; Nobili F; Morbelli S; Drzezga A; Didic M; van Berckel BN; Salmon E; Bastin C; Dauby S; Santana I; Baldeiras I; de Mendonça A; Silva D; Wallin A; Nordlund A; Coloma PM; Wientzek A; Alexander M; Novak GP; Gordon MF; Alzheimer's Disease Neuroimaging Initiative; Wallin ÅK; Hampel H; Soininen H; Herukka S-K; Scheltens P; Verhey FR; Visser PJ
Journal article: ALZHEIMERS & DEMENTIA. 2017;13(7S_Part_22):p1047-p1048

[P3–273]: EFFECTS OF RISPERIDONE AND GALANTAMINE TREATMENT ON ALZHEIMER BIOMARKER LEVELS IN CEREBROSPINAL FLUID

Bloniecki V; Freund‐Levi Y; Blennow K; Aarsland D; Cummings JL; Winblad B
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;57(2):387-393

Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid.

Bloniecki V; Aarsland D; Blennow K; Cummings J; Falahati F; Winblad B; Freund-Levi Y
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;56(2):543-555

Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes.

van Waalwijk van Doorn LJC; Gispert JD; Kuiperij HB; Claassen JAHR; Arighi A; Baldeiras I; Blennow K; Bozzali M; Castelo-Branco M; Cavedo E; Emek-Savaş DD; Eren E; Eusebi P; Farotti L; Fenoglio C; Ormaechea JF; Freund-Levi Y; Frisoni GB; Galimberti D; Genc S; Greco V; Hampel H; Herukka S-K; Liu Y; Lladó A; Lleó A; Nobili FM; Oguz KK; Parnetti L; Pereira J; Picco A; Pikkarainen M; de Oliveira CR; Saka E; Salvadori N; Sanchez-Valle R; Santana I; Scarpini E; Scheltens P; Soininen H; Tarducci R; Teunissen C; Tsolaki M; Urbani A; Vilaplana E; Visser PJ; Wallin AK; Yener G; Molinuevo JL; Meulenbroek O; Verbeek MM
Journal article: ALZHEIMERS & DEMENTIA. 2016;12(7S_Part_22):p1059-p1061

P4‐122: Prevalence of Vascular Risk Factors in Different Stages of Prodromal Alzheimer’s Disease and Its Influence on Cognitive Decline

Bos I; Vos SJB; Frölich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Rüther E; Engelborghs S; Niemantsverdriet E; De Roeck EE; Tsolaki M; Freund-Levi Y; Johannsen P; Vandenberghe R; Lleó A; Alcolea D; Frisoni GB; Galluzzi S; Nobili F; Morbelli S; Drzezga A; Didic M; van Berckel BNM; Salmon E; Bastin C; Dauby S; Santana I; Baldeiras I; Mendonça A; Silva D; Wallin A; Nordlund A; Foskett N; Coloma P; Alexander M; Wientzek-Fleischmann A; Nevado-Holgado A; Gungabissoon U; Novak GP; Gordon MF; Wallin ÅK; Hampel H; Soininen H; Scheltens P; Verhey FRJ; Visser PJ
Article: JOURNAL OF ALZHEIMERS DISEASE. 2015;48(3):805-812

Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer's Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study.

Eriksdotter M; Vedin I; Falahati F; Freund-Levi Y; Hjorth E; Faxen-Irving G; Wahlund L-O; Schultzberg M; Basun H; Cederholm T; Palmblad J
Journal article: CLINICAL NUTRITION. 2015;34:s245-s246

SUN-LB030: Does Fatty Acid Composition in Subcutaneous Fat Differ Between Patients With Alzheimer’s Disease and their Cohabiting Relatives?

Faxen-Irving G; Falahati F; Basun H; Palmblad J; Cederholm T; Vedin I; Eriksdotter M; Wahlund L-O; Schultzberg M; Hjorth E; Freund-Levi Y
Journal article: CLINICAL NUTRITION. 2015;34:s247-s248

SUN-LB035: Does APOE4 Carriership Influence Potential Omega-3 Fatty Acid Treatment Effects on Cognition or Psychiatric Status in Patients With Mild to Moderate Alzheimer’S Disease: The Omegad Study

Freund-Levi Y; Falahati F; Hjorth E; Cederholm T; Eriksdotter M; Vedin I; Faxen-Irving G; Wahlund L-O; Schultzberg M; Basun H; Palmblad J
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2015;313(19):1924-1938

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Jansen WJ; Ossenkoppele R; Knol DL; Tijms BM; Scheltens P; Verhey FRJ; Visser PJ; Amyloid Biomarker Study Group; Aalten P; Aarsland D; Alcolea D; Alexander M; Almdahl IS; Arnold SE; Baldeiras I; Barthel H; van Berckel BNM; Bibeau K; Blennow K; Brooks DJ; van Buchem MA; Camus V; Cavedo E; Chen K; Chetelat G; Cohen AD; Drzezga A; Engelborghs S; Fagan AM; Fladby T; Fleisher AS; van der Flier WM; Ford L; Förster S; Fortea J; Foskett N; Frederiksen KS; Freund-Levi Y; Frisoni GB; Froelich L; Gabryelewicz T; Gill KD; Gkatzima O; Gómez-Tortosa E; Gordon MF; Grimmer T; Hampel H; Hausner L; Hellwig S; Herukka S-K; Hildebrandt H; Ishihara L; Ivanoiu A; Jagust WJ; Johannsen P; Kandimalla R; Kapaki E; Klimkowicz-Mrowiec A; Klunk WE; Köhler S; Koglin N; Kornhuber J; Kramberger MG; Van Laere K; Landau SM; Lee DY; de Leon M; Lisetti V; Lleó A; Madsen K; Maier W; Marcusson J; Mattsson N; de Mendonça A; Meulenbroek O; Meyer PT; Mintun MA; Mok V; Molinuevo JL; Møllergård HM; Morris JC; Mroczko B; Van der Mussele S; Na DL; Newberg A; Nordberg A; Nordlund A; Novak GP; Paraskevas GP; Parnetti L; Perera G; Peters O; Popp J; Prabhakar S; Rabinovici GD; Ramakers IHGB; Rami L; Resende de Oliveira C; Rinne JO; Rodrigue KM; Rodríguez-Rodríguez E; Roe CM; Rot U; Rowe CC; Rüther E; Sabri O; Sanchez-Juan P; Santana I; Sarazin M; Schröder J; Schütte C; Seo SW; Soetewey F; Soininen H; Spiru L; Struyfs H; Teunissen CE; Tsolaki M; Vandenberghe R; Verbeek MM; Villemagne VL; Vos SJB; van Waalwijk van Doorn LJC; Waldemar G; Wallin A; Wallin ÅK; Wiltfang J; Wolk DA; Zboch M; Zetterberg H
Article: BRAIN. 2015;138(Pt 5):1327-1338

Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage.

Vos SJB; Verhey F; Frölich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Rüther E; Nobili F; Morbelli S; Frisoni GB; Drzezga A; Didic M; van Berckel BNM; Simmons A; Soininen H; Kłoszewska I; Mecocci P; Tsolaki M; Vellas B; Lovestone S; Muscio C; Herukka S-K; Salmon E; Bastin C; Wallin A; Nordlund A; de Mendonça A; Silva D; Santana I; Lemos R; Engelborghs S; Van der Mussele S; Alzheimer’s Disease Neuroimaging Initiative; Freund-Levi Y; Wallin ÅK; Hampel H; van der Flier W; Scheltens P; Visser PJ
Article: JOURNAL OF LIPID RESEARCH. 2015;56(3):674-681

Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study.

Wang X; Hjorth E; Vedin I; Eriksdotter M; Freund-Levi Y; Wahlund L-O; Cederholm T; Palmblad J; Schultzberg M
Article: CURRENT ALZHEIMER RESEARCH. 2015;12(1):69-79

Predicting progression from cognitive impairment to Alzheimer's disease with the Disease State Index.

Hall A; Mattila J; Koikkalainen J; Lötjonen J; Wolz R; Scheltens P; Frisoni G; Tsolaki M; Nobili F; Freund-Levi Y; Minthon L; Frölich L; Hampel H; Visser PJ; Soininen H
Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;42(3):823-831

Effects of supplementation with omega-3 fatty acids on oxidative stress and inflammation in patients with Alzheimer's disease: the OmegAD study.

Freund-Levi Y; Vedin I; Hjorth E; Basun H; Faxén Irving G; Schultzberg M; Eriksdotter M; Palmblad J; Vessby B; Wahlund L-O; Cederholm T; Basu S
Article: BRAIN RESEARCH BULLETIN. 2014;108:88-93

Neuropsychiatric symptoms in dementia-a role for neuroinflammation?

Holmgren S; Hjorth E; Schultzberg M; Lärksäter M; Frenkel D; Tysen-Bäckström AC; Aarsland D; Freund-Levi Y
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_11):p455

P1‐384: EFFECTS OF OMEGA‐3 FATTY ACID SUPPLEMENTATION ON PLASMA FATTY ACIDS, GENDER EFFECTS, AND EFFECTS ON COGNITION IN ALZHEIMER'S PATIENTS: THE OMEGAD STUDY

Eriksdotter M; Falahati F; Vedin I; Freund‐Levi Y; Hjorth E; Faxen‐Irving G; Wahlund L; Schultzberg M; Basun H; Cederholm T; Palmblad J
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_4):p265

O4‐07‐05: ADDED VALUE OF MRI BIOMARKERS TO NEUROPSYCHOLOGICAL TEST PERFORMANCE FOR PREDICTION OF AD IN SUBJECTS WITH MCI

Clerx L; Dierckx E; van der Pol L; van Rossum I; Verhey FRJ; Aalten P; Barkhof F; Wolz R; Rueckert D; Frisoni G; Tsolaki M; Nobili F; Freund‐Levi Y; Wallin AK; Frolich L; Hampel HJ; Soininen H; Scheltens P; Visser PJ
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA. 2014;4(2):335-343

Agitation in dementia: relation to core cerebrospinal fluid biomarker levels.

Bloniecki V; Aarsland D; Cummings J; Blennow K; Freund-Levi Y
Article: JOURNAL OF INTERNAL MEDICINE. 2014;275(4):428-436

Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study.

Freund Levi Y; Vedin I; Cederholm T; Basun H; Faxén Irving G; Eriksdotter M; Hjorth E; Schultzberg M; Vessby B; Wahlund L-O; Salem N; Palmblad J
Article: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY. 2014;22(4):341-348

Galantamine versus risperidone treatment of neuropsychiatric symptoms in patients with probable dementia: an open randomized trial.

Freund-Levi Y; Jedenius E; Tysen-Bäckström AC; Lärksäter M; Wahlund L-O; Eriksdotter M
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2014;38(3-4):234-244

Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study.

Freund-Levi Y; Bloniecki V; Auestad B; Tysen Bäckström AC; Lärksäter M; Aarsland D
Journal article: ALZHEIMERS & DEMENTIA. 2013;9(4S_Part_17):p669-p670

P3–306: A randomized controlled trial investigating the effects of Souvenaid in prodromal Alzheimer's disease: Baseline characteristics of the LipiDiDiet study

Visser PJ; Soininen H; Kivipelto M; Freund‐Levi Y; Kamphuis P; Wieggers RL; Hartmann T
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;36(1):1-6

Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study.

Faxén-Irving G; Freund-Levi Y; Eriksdotter-Jönhagen M; Basun H; Hjorth E; Palmblad J; Vedin I; Cederholm T; Wahlund L-O
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;35(4):697-713

Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers.

Hjorth E; Zhu M; Toro VC; Vedin I; Palmblad J; Cederholm T; Freund-Levi Y; Faxen-Irving G; Wahlund L-O; Basun H; Eriksdotter M; Schultzberg M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(4):580-593

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients.

Forsberg A; Juréus A; Cselényi Z; Eriksdotter M; Freund-Levi Y; Jeppsson F; Swahn B-M; Sandell J; Julin P; Schou M; Andersson J; Johnström P; Varnäs K; Halldin C; Farde L; Svensson S
Journal article: ALZHEIMERS & DEMENTIA. 2012;8(4S_Part_16):p602

P3‐419: The LipiDiDiet study: Rationale and study design

Freund‐Levi Y; Visser PJ; Kivipelto M; Wieggers RL; Hartmann T; Soininen H
Article: PLOS ONE. 2012;7(4):e35425

Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study.

Vedin I; Cederholm T; Freund-Levi Y; Basun H; Garlind A; Irving GF; Eriksdotter-Jönhagen M; Wahlund L-O; Dahlman I; Palmblad J
Journal article: CLINICAL NUTRITION. 2011;6(1):9

OP020 OXIDATIVE STRESS AND COX-MEDIATED INFLAMMATION IN PATIENTS WITH ALZHEIMER'S DISEASE AND EFFECTS OF N-3 FATTY ACID SUPPLEMENTATION – THE OMEGAD STUDY

Freund-Levi Y; Cederholm T; Basu S; group OBOOS
Article: AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS. 2010;25(6):521-526

To be a good food provider: an exploratory study among spouses of persons with Alzheimer's disease.

Fjellström C; Starkenberg A; Wesslén A; Licentiate MS; Tysén Bäckström A-C; Faxén-Irving G; OmegAD Study Group
Article: JOURNAL OF LIPID RESEARCH. 2010;51(5):1179-1185

Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study.

Vedin I; Cederholm T; Freund-Levi Y; Basun H; Hjorth E; Irving GF; Eriksdotter-Jönhagen M; Schultzberg M; Wahlund L-O; Palmblad J
Journal article: EUROPEAN PSYCHIATRY. 2010;25(S1):1595

PW01-263 - Galantamine compared to risperidone in neuropsychiatric and behavioural symptoms in Alzheimer patients: a one-center clinical trial in 100 patients

Freund-Levi Y; Wahlund L-O; Eriksdotter-Jönhagen M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(11):1859-1863

Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184.

Nyberg S; Jönhagen ME; Cselényi Z; Halldin C; Julin P; Olsson H; Freund-Levi Y; Andersson J; Varnäs K; Svensson S; Farde L
Article: LANCET NEUROLOGY. 2009;8(7):619-627

Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.

Visser PJ; Verhey F; Knol DL; Scheltens P; Wahlund L-O; Freund-Levi Y; Tsolaki M; Minthon L; Wallin AK; Hampel H; Bürger K; Pirttila T; Soininen H; Rikkert MO; Verbeek MM; Spiru L; Blennow K
Journal article: ALZHEIMERS & DEMENTIA. 2009;5(4S_Part_3):p97

F2‐01‐01: Why Alzheimer patients and caregivers participate in randomized clinical trials

Akenine U; Andreasen N; Freund‐Levi Y; Winblad B; Kivipelto M
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2009;27(5):481-490

Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study.

Freund-Levi Y; Hjorth E; Lindberg C; Cederholm T; Faxen-Irving G; Vedin I; Palmblad J; Wahlund L-O; Schultzberg M; Basun H; Eriksdotter Jönhagen M
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2009;57(1):11-17

Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study.

Irving GF; Freund-Levi Y; Eriksdotter-Jönhagen M; Basun H; Brismar K; Hjorth E; Palmblad J; Vessby B; Vedin I; Wahlund L-O; Cederholm T
Journal article: CLINICAL NUTRITION. 2009;4(2):20

O043 EFFECTS OF A DHA RICH N-3 FATTY ACID SUPPLEMENTATION ON GENE EXPRESSION CHANGES IN BLOOD LEUKOCYTES: THE OMEGAD STUDY

Vedin I; Cederholm T; Freund-Levi Y; Basun H; Garlind A; Faxén-Irving G; Jönhagen ME; Wahlund L; Dahlman I; Palmblad J
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2008;87(6):1616-1622

Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study.

Vedin I; Cederholm T; Freund Levi Y; Basun H; Garlind A; Faxén Irving G; Jönhagen ME; Vessby B; Wahlund L-O; Palmblad J
Article: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. 2008;23(2):161-169

Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms.

Freund-Levi Y; Basun H; Cederholm T; Faxén-Irving G; Garlind A; Grut M; Vedin I; Palmblad J; Wahlund L-O; Eriksdotter-Jönhagen M
Article: ARCHIVES OF NEUROLOGY. 2006;63(10):1402-1408

Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial.

Freund-Levi Y; Eriksdotter-Jönhagen M; Cederholm T; Basun H; Faxén-Irving G; Garlind A; Vedin I; Vessby B; Wahlund L-O; Palmblad J
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_3):s64

O3–05–08: A randomized double–blind trial with omega–3 fatty acid treatment in mild to moderate Alzheimer's disease

Freund-Levi Y; Jonhagen ME; Cederholm T; Basun H; Faxen-Irving G; Garlind A; Vedin I; Vessby B; Wahlund L-O; Palmblad J
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_9):s271-s272

P2–130: Correlation of inflammatory factors with Alzheimer biomarkers

Schultzberg M; Freund-Levi Y; Garlind A; Cederholm T; Palmblad J; Wahlund L-O; Eriksdotter-Jonhagen M; Basun H
Journal article: LAKARTIDNINGEN. 1991;88(5):310-312

[Light therapy of depression].

Wetterberg L; Kjellman B; Thalén BE; Beck-Friis J; Freund-Levi Y; Friberg Y; Nordlund AL; Björkstén KS; Wiberg B; Zettergren M
Journal article: MAGNETIC RESONANCE IMAGING. 1989;7(2):225-230

Ultra low field brain MRI in HIV transfusion infected patients.

Freund-Levi Y; Sääf J; Wahlund LO; Wetterberg L
Show more

All other publications

Preprint: MEDRXIV. 2023

Blood-based multivariate methylation risk score for cognitive impairment and dementia

Koetsier J; Cavill R; Reijnders R; Harvey J; Deckers K; Köhler S; Eijssen L; Smith RG; Smith AR; Burrage J; Walker EM; Shireby G; Hannon E; Dempster E; Frayling T; Mill J; Dobricic V; Sommerer Y; Johannsen P; Wittig M; Franke A; Vandenberghe R; Schaeverbeke J; Freund-Levi Y; Frölich L; Scheltens P; Teunissen C; Frisoni G; Blin O; Richardson J; Bordet R; Engelborghs S; de Roeck E; Martinez-Lage P; Tainta M; Lleó A; Sala I; Popp J; Peyratout G; Verhey F; Tsolaki M; Andreasson U; Blennow K; Zetterberg H; Streffer J; Vos SJB; Lovestone S; Visser P-J; Bertram L; Lunnon K; Pishva E
Corrigendum: MOLECULAR NEURODEGENERATION. 2022;17(1):37

Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.

Visser PJ; Reus LM; Gobom J; Jansen I; Dicks E; van der Lee SJ; Tsolaki M; Verhey FRJ; Popp J; Martinez-Lage P; Vandenberghe R; Lleó A; Molinuevo JL; Engelborghs S; Freund-Levi Y; Froelich L; Sleegers K; Dobricic V; Lovestone S; Streffer J; Vos SJB; Bos I; ADNI; Smit AB; Blennow K; Scheltens P; Teunissen CE; Bertram L; Zetterberg H; Tijms BM
Preprint: MEDRXIV. 2021

Rare variants in IFFO1, DTNB and NLRC3 associate with Alzheimer’s disease CSF profile of neuronal injury and inflammation

Neumann A; Küçükali F; Bos I; Vos SJB; Engelborghs S; De Pooter T; Joris G; De Rijk P; De Roeck E; Tsolaki M; Verhey F; Martinez-Lage P; Tainta M; Frisoni G; Blin O; Richardson J; Bordet R; Scheltens P; Popp J; Peyratout G; Johannsen P; Frölich L; Vandenberghe R; Freund-Levi Y; Streffer J; Lovestone S; Legido-Quigley C; Kate MT; Barkhof F; Strazisar M; Zetterberg H; Bertram L; Visser PJ; van Broeckhoven C; Sleegers K; group E-AS; Initiative ADN
Preprint: MEDRXIV. 2021

Sex-specific metabolic pathways associate with Alzheimer’s Disease (AD) endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery cohort

Xu J; Green R; Kim M; Lord J; Ebshiana A; Westwood S; Baird AL; Nevado-Holgado AJ; Shi L; Hye A; Snowden SG; Bos I; Vos SJB; Vandenberghe R; Teunissen CE; Kate MT; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck EE; Engelborghs S; Sleegers K; Bordet R; Rami L; Kettunen P; Tsolaki M; Verhey FRJ; Alcolea D; Lleó A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Proitsi P; Legido-Quigley C
Conference publication: EUROPEAN PSYCHIATRY. 2021;64:S690

Physical training for patients with depression and anxiety - a randomized controlled study

Zhai Q; Freund-Levi Y; Horn A; Fridenberger A-C; Lager E; Montgomery S; Persson J
Preprint: MEDRXIV. 2020;MEDRXIV

Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease.

Visser PJ; Reus LM; Gobom J; Jansen I; Dicks E; Tsolaki M; Verhey FRJ; Popp J; Martinez-Lage P; Vandenberghe R; Lleó A; Molinuevo JL; Engelborghs S; Freund-Levi Y; Froelich L; Sleegers K; Dobricic V; Hong S; Lovestone S; Streffer J; Vos SJB; Bos I; Smit AB; Blennow K; Scheltens P; Teunissen CE; Bertram L; Zetterberg H; Tijms BM
Review: ALZHEIMER'S AND DEMENTIA: TRANSLATIONAL RESEARCH AND CLINICAL INTERVENTIONS. 2020;6(1):e12016

Agitation and impulsivity in mid and late life as possible risk markers for incident dementia.

Bateman DR; Gill S; Hu S; Foster ED; Ruthirakuhan MT; Sellek AF; Mortby ME; Matušková V; Ng KP; Tarawneh RM; Freund-Levi Y; Kumar S; Gauthier S; Rosenberg PB; Ferreira de Oliveira F; Devanand DP; Ballard C; Ismail Z; International Society to Advance Alzheimer's Resea
Preprint: RESEARCH SQUARE. 2019

Antipsychotic Drugs Attenuate Interleukin-6 Secretion by Microglia Via Dopamine Inhibition

Mekori-Domachevsky E; Nash Y; Rabinovich A; Frenkel D; Freund-Levi Y
Preprint: MEDRXIV. 2019

A metabolite-based machine learning approach to diagnose Alzheimer’s-type dementia in blood: Results from the European Medical Information Framework for Alzheimer’s Disease biomarker discovery cohort

Stamate D; Kim M; Proitsi P; Westwood S; Baird A; Nevado-Holgado A; Hye A; Bos I; Vos S; Vandenberghe R; Teunissen CE; Kate MT; Scheltens P; Gabel S; Meersmans K; Blin O; Richardson J; De Roeck E; Engelborghs S; Sleegers K; Bordet R; Rami L; Kettunen P; Tsolaki M; Verhey F; Alcolea D; Lléo A; Peyratout G; Tainta M; Johannsen P; Freund-Levi Y; Frölich L; Dobricic V; Frisoni GB; Molinuevo JL; Wallin A; Popp J; Martinez-Lage P; Bertram L; Blennow K; Zetterberg H; Streffer J; Visser PJ; Lovestone S; Legido-Quigley C
Preprint: SSRN ELECTRONIC JOURNAL. 2019

Biomarker Based and Individualized Prognosis for Patients with Mild Cognitive Impairment: Towards a Personalized Medicine Approach for AD

van Maurik I; Bos I; Vos SJ; Bouwman FH; Teunissen CE; Scheltens P; Barkhof F; Frolich L; Kornhuber J; Wiltfang J; Maier W; Peters O; Ruther E; Nobili F; Frisoni G; Spiru L; Freund-Levi Y; Wallin AK; Hampel H; Soininen H; Tsolaki M; Verhey F; Simmons A; Kloszewska I; Mecocci P; Vellas B; Lovestone S; Galluzzi S; Herukka S-K; Santana I; Baldeiras I; de Mendonça A; Silva D; Chetelat G; Egret S; Palmqvist S; Hansson O; Visser P-J; Initiative ADN; Berkhof J; van der Flier WM
Corrigendum: ALZHEIMERS RESEARCH & THERAPY. 2018;10(1):56

Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline.

Bos I; Verhey FR; Ramakers IHGB; Jacobs HIL; Soininen H; Freund-Levi Y; Hampel H; Tsolaki M; Wallin ÅK; van Buchem MA; Oleksik A; Verbeek MM; Rikkert MO; van der Flier WM; Scheltens P; Aalten P; Visser PJ; Vos SJB
Review: ADVANCES IN NUTRITION. 2017;8(1):17-26

Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease.

Shlisky J; Bloom DE; Beaudreault AR; Tucker KL; Keller HH; Freund-Levi Y; Fielding RA; Cheng FW; Jensen GL; Wu D; Meydani SN
Letter: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY. 2014;22(9):951

Response to Bogaiksy's letter to the editor.

Freund-Levi Y; Jedenius E; Wahlund L-O; Eriksdotter M; Tysen-Bäckström AC; Lärksäter M
Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2012;15(2):134-143

Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid.

Hjorth E; Freund-Levi Y
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2012;19:112

Agitation - relation to clinical and dementia biomarkers in cerebrospinal fluid

Bloniecki V; Freund-Levi Y; Aarsland D; Blennow K
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2012;19:112

Baseline characteristics of subjects with prodromal Alzheimer's disease: the LipiDiDiet study

Freund-Levi Y; Visser PJ; Kivipelto M; Kamphuis PJGH; Wieggers RL; Hartmann T; Soininen H
Conference publication: ANNALS OF NEUROLOGY. 2012;72:S53-S54

Baseline Characteristics of Subjects with Prodromal Alzheimer's Disease: The LipiDiDiet Study

Freund-Levi Y; Visser PJ; Kivipelto M; Wieggers RL; Hartmann T; Soininen H
Conference publication: EUROPEAN PSYCHIATRY. 2010;25

GALANTAMINE COMPARED TO RISPERIDONE IN NEUROPSYCHIATRIC AND BEHAVIOURAL SYMPTOMS IN ALZHEIMER PATIENTS: A ONE-CENTER CLINICAL TRIAL IN 100 PATIENTS

Freund-Levi Y; Wahlund L-O; Eriksdotter-Jonhagen M
Conference publication: FASEB JOURNAL. 2009;23:543.10

N-3 fatty acid treatment and plasma transthyretin in patients with Alzheimer's disease

Irving GF; Freund-Levi Y; Eriksdotter-Jonhagen M; Basun H; Palmblad J; Vedin I; Wahlund L-O; Cederholm T
Corrigendum: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2009;57(3):579

Omega Fatty Acid Supplementation Effects on Weight and Appetite in Patients with Alzheimer's Disease: The Omega-3 Alzheimer's Disease Study (vol 57, pg 11, 2009)

Irving GF; Freund-Levi Y
Review: LAKARTIDNINGEN. 2007;104(44):3268-3271

[Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited].

Palmblad J; Eriksdotter-Jönhagen M; Freund-Levi Y; Cederholm T
Review: LAKARTIDNINGEN. 2006;103(6):369-371

[Administration of symptom-relieving drugs in Alzheimer disease is beneficial].

Nordberg A; Eriksdotter-Jönhagen M; Garlind A; Grut M; Freund-Levi Y; Cornelius C; Ekström A; Fastbom J; Sedvall M; Viitanen M
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S471

Safety and tolerability of omega-3 fatty acids in patients with Alzheimers disease

Freund-Levi Y; Jonhagen ME; Wahlund LO; Basun H; Palmblad J; Cederholm T
Conference publication: FASEB JOURNAL. 2004;18(4):A501

Inflammatory gene expression changes by omega-3 fatty acids in patients with Alzheimer's disease

Vedin I; Cederholm T; Lidén J; Freund-Levi Y; Palmblad J
Show more

Grants

Rehabilitation profile for post COVID-19 patients

Swedish Research Council for Environment Agricultural Sciences and Spatial Planning

1 November 2020 - 31 October 2021

Employments

Senior Lecturer/Senior Physician, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2015
Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2008

Articles

All other publications

Grants

Employments

Degrees and Education

News from KI

Events from KI