Ahmed Osman

I received my undergraduate degree in Veterinary Medicine from the University of Khartoum, Sudan, and specialized in pathology. I was performing histopathological analyses, necropsies, along with teaching and research. 

In master years, my research focused on the infectious diseases, developing molecular assays for characterization of the genotypes of the parasitic disease Hydatidosis that caused by tape worm Echinococcus granulosus

For my PhD, I was enrolled in a Regenerative Neuroscience Program at the Karolinska Institutet in Sweden, investigating the role of neural stem cells in brain repair after injures caused by ischemia or cranial irradiation. Since the brain injury is often accompanied by inflammation, my research then focused on how the immune response influences neural stem cells behaviour, with particular focus on microglia as the resident immune cell in the brain.

Over the time, I developed an interest to investigate the central nervous system cancers, especially the cancer dissemination, known as cancer metastasis. Therefore, I joined the Adrienne Boire Laboratory at Memorial Sloan Kettering Cancer Center in New York City, USA, for a postdoctoral training, investigating the molecular underpinnings of leptomeningeal metastasis response to craniospinal irradiation.

Our research focuses on two lines:

2- Understanding the molecular basis of the neurotoxicity and neurocognitive impairments induced by the brain cancers and the cancer therapies. Cancer therapy-induced neurotoxicity is a major clinical challenge in neuro-oncology as it can occur in up 95% of cancer survivors treated with cranial irradiation or chemotherapy, especially in children, with no available treatment.