Brinton Seashore-Ludlow

Senior research specialist

About me

I currently hold two positions at the Karolinska Institute (KI). I am a team leader in the larger group of Olli Kallioniemi at the department of Oncology-Pathology. I am a group leader at SciLifeLab, and head of the biology team at Chemical Biology Consortium Sweden (CBCS) KI node.

Research description

Our ultimate goal is to promote the move away from one-size-fits-all therapies to improve patient outcome through treatment stratification and tailoring. Despite advances in precision medicine diagnostics, there are still major opportunities to improve individualized patient care throughout the entire health care value chain, spanning from preclinical studies in drug discovery through to the design of precision diagnostics. Research in my team focuses on challenges central to these fields, developing technologies and disease models that enable direct measurement of patient response to treatment ex vivo and investigation of the molecular determinants of drug response. Such methods and model systems are critical to improve the study of disease biology, identify and validate new drug targets, correctly prioritize drug candidates for clinical trials, uncover potential biomarkers for future patient stratification and have even recently been used successfully as diagnostics to match patients to effective treatments.

Our translational research group and surrounding team of clinicians and experts has two major themes as described below united by the main goal of investigating drug response and biomarkers in primary patient cells and other near-patient models of disease.

Image of liver cells by Emma Åkerlund


Teaching portfolio

I co-organize a doctoral course in cancer drug discovery.