Carl Jorns

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About me

Carl studied medicine at Albert-Ludwigs-Universität Freiburg, Germany and
obtained a doctoral degree at the department of Virology with a thesis on
interferon stimulated genes. He received clinical surgical training in
general and transplantation surgery at Karolinska University Hospital. Carl
obtained his PhD at Karolinska Institutet in 2015 on clinical and
experimental hepatocyte transplantation. Carl is currently the head
of liver transplantation at the Department of Transplantation Surgery,
Karolinska University Hospital.

Research

Carl´s research involves translational research in organ donation and
transplantation as well as regenerative medicine. His research includes organ
donation from neonatal donors, clinical and experimental hepatocyte
transplantation.

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):1752

Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF.

Kvedaraite E; Lourda M; Mouratidou N; Düking T; Padhi A; Moll K; Czarnewski P; Sinha I; Xagoraris I; Kokkinou E; Damdimopoulos A; Weigel W; Hartwig O; Santos TE; Soini T; Van Acker A; Rahkonen N; Flodström Tullberg M; Ringqvist E; Buggert M; Jorns C; Lindforss U; Nordenvall C; Stamper CT; Unnersjö-Jess D; Akber M; Nadisauskaite R; Jansson J; Vandamme N; Sorini C; Grundeken ME; Rolandsdotter H; Rassidakis G; Villablanca EJ; Ideström M; Eulitz S; Arnell H; Mjösberg J; Henter J-I; Svensson M
Article: AMERICAN JOURNAL OF CASE REPORTS. 2023;24:e938678

Liver Transplantation for Liver Metastasis of a Pseudopapillary Pancreatic Neoplasm in a Male Patient.

Sznajder Granat R; Romano A; Villard C; Lissing M; Joneberg J; Danielsson O; Fernández Moro C; Jorns C
Article: EJSO. 2022;48(12):2432-2439

Prediction of survival in patients with colorectal liver metastases- development and validation of a prognostic score model.

Villard C; Abdelrafee A; Habib M; Ndegwa N; Jorns C; Sparrelid E; Allard M-A; Adam R
Article: TRIALS. 2022;23(1):831

SOULMATE: the Swedish study of liver transplantation for isolated colorectal cancer liver metastases not suitable for operation or ablation, compared to best established treatment-a randomized controlled multicenter trial.

Reivell V; Hagman H; Haux J; Jorns C; Lindnér P; Taflin H
Article: HPB. 2022;24(7):1138-1144

Liver transplantation in patients with post-hepatectomy liver failure - A Northern European multicenter cohort study.

Sparrelid E; Thorsen T; Sauter C; Jorns C; Stål P; Nordin A; de Boer MT; Buis C; Yaqub S; Schultz NA; Larsen PN; Sallinen V; Line P-D; Gilg S
Article: EJSO. 2022;48(7):1656-1663

Prognostic impact of inter-metastatic heterogeneity of viable tumour cells in colorectal liver metastases.

Strömberg C; Martinez de la Maza L; Fernández Moro C; Gerling M; Jorns C; Sparrelid E; Löhr MJ; Villard C
Article: CELL TRANSPLANTATION. 2022;31:9636897211069900-096368972110699

Procurement and Evaluation of Hepatocytes for Transplantation From Neonatal Donors After Circulatory Death.

Bluhme E; Henckel E; Gramignoli R; Kjellin T; Hammarstedt C; Nowak G; Karadagi A; Johansson H; Jynge Ö; Söderström M; Fischler B; Strom S; Ellis E; Hallberg B; Jorns C
Article: PEDIATRIC TRANSPLANTATION. 2021;25(6):e13993

Comparison of cystatin C, creatinine, and iohexol clearance in pediatric liver transplantation-a retrospective cohort study.

Bluhme E; Malenicka S; Fischler B; Nemeth A; Berg UB; Jorns C
Article: CHILDREN-BASEL. 2021;8(9):760

ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network.

Markiewicz-Kijewska M; Kaliciński P; Torres Canizales J; Di Giorgio A; Baumann U; Jorns C; Baker A; Lopes MF; Frauca Remacha E; Lopez-Granados E; Jara Vega P; Basso M-S; Kowalewski G; Kamińska D; Ferreira S; Liccardo D; Pietrobattista A; Spada M; On Behalf Of Ern TransplantChild Healthcare Workin
Article: HEPATOBILIARY SURGERY AND NUTRITION. 2021;10(4):476-485

The potential use of extended criteria donors and eligible recipients in liver transplantation for unresectable colorectal liver metastases in Central Sweden.

Villard C; Westman J; Frank J; Jynge O; Sparrelid E; Jorns C
Article: EJSO. 2021;47(8):2038-2045

Conversion therapy in patients with colorectal liver metastases.

Villard C; Habib M; Nordenvall C; Nilsson PJ; Jorns C; Sparrelid E
Article: SCIENCE ADVANCES. 2021;7(30):eabg5733

Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.

Adori C; Daraio T; Kuiper R; Barde S; Horvathova L; Yoshitake T; Ihnatko R; Valladolid-Acebes I; Vercruysse P; Wellendorf AM; Gramignoli R; Bozoky B; Kehr J; Theodorsson E; Cancelas JA; Mravec B; Jorns C; Ellis E; Mulder J; Uhlén M; Bark C; Hökfelt T
Article: MOLECULAR THERAPY. 2021;29(5):1903-1917

Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.

Zabulica M; Srinivasan RC; Akcakaya P; Allegri G; Bestas B; Firth M; Hammarstedt C; Jakobsson T; Jakobsson T; Ellis E; Jorns C; Makris G; Scherer T; Rimann N; van Zuydam NR; Gramignoli R; Forslöw A; Engberg S; Maresca M; Rooyackers O; Thöny B; Häberle J; Rosen B; Strom SC
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:752104

CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung.

Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; von Kries A; Jorns C; Marquardt N; Michaëlsson J; Willinger T
Article: SCIENTIFIC REPORTS. 2020;10(1):7052

Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency.

Karadagi A; Cavedon AG; Zemack H; Nowak G; Eybye ME; Zhu X; Guadagnin E; White RA; Rice LM; Frassetto AL; Strom S; Jorns C; Martini PGV; Ellis E
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2020;198:105558

Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine.

Santinha D; Klopot A; Marques I; Ellis E; Jorns C; Johansson H; Melo T; Antonson P; Jakobsson T; Félix V; Gustafsson J-Å; Domingues MR; Mode A; Helguero LA
Article: TRANSPLANTATION. 2020;104(3):522-525

First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child.

Nordström J; Lundgren M; Jorns C; Fischler B; Arnell H; Dlugosz R; Sandberg J; Wennberg L; Nowak G
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2020;10(2):106-113

Blood Group Antigen Expression in Isolated Human Liver Cells in Preparation for Implementing Clinical ABO-Incompatible Hepatocyte Transplantation.

Tokodai K; Kumagai-Braesch M; Karadagi A; Johansson H; Ågren N; Jorns C; Ericzon B-G; Ellis E
Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:554922

Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes.

Johansson H; Søndergaard JN; Jorns C; Kutter C; Ellis ECS
Article: TRANSPLANTATION. 2019;103(3):630-637

Open Randomized Multicenter Study to Evaluate Safety and Efficacy of Low Molecular Weight Sulfated Dextran in Islet Transplantation.

von Zur-Mühlen B; Lundgren T; Bayman L; Berne C; Bridges N; Eggerman T; Foss A; Goldstein J; Jenssen T; Jorns C; Morrison Y; Rydén M; Schwieger T; Tufveson G; Nilsson B; Korsgren O
Article: CELL TRANSPLANTATION. 2018;27(11):1692-1704

Ex Vivo Generation of Donor Antigen-Specific Immunomodulatory Cells: A Comparison Study of Anti-CD80/86 mAbs and CTLA4-lg Costimulatory Blockade.

Watanabe M; Kumagai-Braesch M; Yao M; Thunberg S; Berglund D; Sellberg F; Jorns C; Enoksson SL; Henriksson J; Lundgren T; Uhlin M; Berglund E; Ericzon B-G
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2018;8(2):162-168

Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood.

Johansson H; Mörk L-M; Li M; Sandblom AL; Björkhem I; Höijer J; Ericzon B-G; Jorns C; Gilg S; Sparrelid E; Isaksson B; Nowak G; Ellis E
Article: ONCOTARGET. 2017;8(36):60257-60269

Characterization of infiltrating lymphocytes in human benign and malignant prostate tissue.

Rådestad E; Egevad L; Jorns C; Mattsson J; Sundberg B; Nava S; Ericzon B-G; Henningsohn L; Levitsky V; Uhlin M
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294

Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers.

Forkel M; Berglin L; Kekäläinen E; Carlsson A; Svedin E; Michaëlsson J; Nagasawa M; Erjefält JS; Mori M; Flodström-Tullberg M; Bergquist A; Ljunggren H-G; Westgren M; Lindforss U; Friberg D; Jorns C; Ellis E; Björkström NK; Mjösberg J
Article: MATURITAS. 2017;96:39-44

Differential expression of sex hormone receptors in abdominal aortic aneurysms.

Villard C; Eriksson P; Kronqvist M; Lengquist M; Jorns C; Hartman J; Roy J; Hultgren R
Article: PLOS ONE. 2017;12(5):e0177279

Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression.

Karadagi A; Johansson H; Zemack H; Salipalli S; Mörk L-M; Kannisto K; Jorns C; Gramignoli R; Strom S; Stokkeland K; Ericzon B-G; Jonigk D; Janciauskiene S; Nowak G; Ellis ECS
Article: AMERICAN JOURNAL OF TRANSPLANTATION. 2016;16(3):1021-1030

De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning.

Jorns C; Nowak G; Nemeth A; Zemack H; Mörk L-M; Johansson H; Gramignoli R; Watanabe M; Karadagi A; Alheim M; Hauzenberger D; van Dijk R; Bosma PJ; Ebbesen F; Szakos A; Fischler B; Strom S; Ellis E; Ericzon B-G
Article: PLOS ONE. 2016;11(9):e0161383

Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins.

Watanabe M; Zemack H; Johansson H; Hagbard L; Jorns C; Li M; Ellis E
Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2014;34(2):109-113

Membrane cut-off does not influence results regarding the measurement of small molecules - a comparative study between 20- and 100-kDa catheters in hepatic microdialysis.

D'souza MA; Ravn A; Jorns C; Nowak G; Isaksson B
Article: CELL TRANSPLANTATION. 2014;23(8):1009-1018

Strategies for short-term storage of hepatocytes for repeated clinical infusions.

Jorns C; Gramignoli R; Saliem M; Zemack H; Mörk L-M; Isaksson B; Nowak G; Ericzon B-G; Strom S; Ellis E
Article: PLOS ONE. 2014;9(8):e105375

In situ characterization of intrahepatic non-parenchymal cells in PSC reveals phenotypic patterns associated with disease severity.

Berglin L; Bergquist A; Johansson H; Glaumann H; Jorns C; Lunemann S; Wedemeyer H; Ellis EC; Björkström NK
Article: LIPIDS. 2014;49(1):71-83

LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.

Kannisto K; Gåfvels M; Jiang Z-Y; Slätis K; Hu X; Jorns C; Steffensen KR; Eggertsen G
Article: CELL TRANSPLANTATION. 2014;23(9):1143-1151

Hypothermic storage of human hepatocytes for transplantation.

Gramignoli R; Dorko K; Tahan V; Skvorak KJ; Ellis E; Jorns C; Ericzon B-G; Fox IJ; Strom SC
Article: STEM CELL RESEARCH. 2013;11(1):563-573

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants.

Gramignoli R; Tahan V; Dorko K; Skvorak KJ; Hansel MC; Zhao W; Venkataramanan R; Ellis ECS; Jorns C; Ericzon B-G; Rosenborg S; Kuiper R; Soltys KA; Mazariegos GV; Fox IJ; Wilson EM; Grompe M; Strom SC
Article: PLOS ONE. 2013;8(11):e78550

Mice with chimeric livers are an improved model for human lipoprotein metabolism.

Ellis ECS; Naugler WE; Parini P; Mörk L-M; Jorns C; Zemack H; Sandblom AL; Björkhem I; Ericzon B-G; Wilson EM; Strom SC; Grompe M
Article: JOURNAL OF SURGICAL RESEARCH. 2012;178(2):959-967

Oxygen-charged HTK-F6H8 emulsion reduces ischemia-reperfusion injury in kidneys from brain-dead pigs.

Asif S; Sedigh A; Nordström J; Brandhorst H; Jorns C; Lorant T; Larsson E; Magnusson PU; Nowak G; Theisinger S; Hoeger S; Wennberg L; Korsgren O; Brandhorst D
Article: WORLD JOURNAL OF HEPATOLOGY. 2012;4(5):176-183

Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution.

Saliem M; Holm F; Tengzelius RB; Jorns C; Nilsson L-M; Ericzon B-G; Ellis E; Hovatta O
Article: CELL TRANSPLANTATION. 2009;18(2):183-193

Generation of hepatocyte-like cells from in vitro transdifferentiated human fetal pancreas.

Sumitran-Holgersson S; Nowak G; Thowfeequ S; Begum S; Joshi M; Jaksch M; Kjaeldgaard A; Jorns C; Ericzon B-G; Tosh D
Article: LIVER TRANSPLANTATION. 2008;14(12):1793-1802

Evidence for no relevance of anti-major histocompatibility complex class I-related chain a antibodies in liver transplantation.

Uzunel M; Kasimu H; Joshi M; Ge X; Liu J; Xu B; Jaksch M; Jorns C; Nowak G; Sumitran-Holgersson S
Article: JOURNAL OF IMMUNOLOGY. 2008;181(6):4219-4228

Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection.

Björkström NK; Gonzalez VD; Malmberg K-J; Falconer K; Alaeus A; Nowak G; Jorns C; Ericzon B-G; Weiland O; Sandberg JK; Ljunggren H-G
Article: JOURNAL OF VIROLOGY. 2007;81(14):7776-7785

Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling.

Holzinger D; Jorns C; Stertz S; Boisson-Dupuis S; Thimme R; Weidmann M; Casanova J-L; Haller O; Kochs G
Article: CARDIOVASCULAR ULTRASOUND. 2007;5:10

Doppler findings in a rare coronary artery fistula.

Jung C; Jorns C; Huhta J
Article: JOURNAL OF MEDICAL VIROLOGY. 2006;78(1):74-82

Rapid and simple detection of IFN-neutralizing antibodies in chronic hepatitis C non-responsive to IFN-alpha.

Jorns C; Holzinger D; Thimme R; Spangenberg HC; Weidmann M; Rasenack J; Blum HE; Haller O; Kochs G
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All other publications

Review: PEDIATRIC TRANSPLANTATION. 2023;27(3):e14486

Potential of neonatal organ donation and outcome after transplantation.

Bluhme E; Henckel E; Jorns C
Thesis / dissertation: 2015

Hepatocyte transplantation : experimental and clinical studies

Jorns, Carl
Corrigendum: PLOS ONE. 2014;9(7):e103870

Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism (vol 8, e78550, 2013)

Ellis ECS; Naugler WE; Parini P; Moerk L-M; Jorns C
Published conference paper: TRANSPLANTATION PROCEEDINGS. 2013;45(5):1780-1786

Serum apolipoprotein E as a marker to monitor graft function after hepatocyte transplantation in a clinically relevant mouse model.

Jorns C; Takahashi T; Callaghan E; Zemack H; Larsson L; Nowak G; Parini P; Ericzon B-G; Ellis E
Review: JOURNAL OF INTERNAL MEDICINE. 2012;272(3):201-223

Hepatocyte transplantation for inherited metabolic diseases of the liver.

Jorns C; Ellis EC; Nowak G; Fischler B; Nemeth A; Strom SC; Ericzon BG
Published conference paper: SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES. 2008;22(4):938-942

Microdialysis monitoring for evaluation of the influence exerted by pneumoperitoneum on the kidney: an experimental study.

Iwata T; Gilispie A; Jorns C; Yamamoto S; Nowak G; Ericzon B-G

Employments

Affiliated to Research, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2022-2025

Degrees and Education

Docent, Karolinska Institutet, 2022
Degree Of Doctor Of Philosophy, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2015

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