About me
I received my PhD from the University of Basel, Switzerland. During my PhD, I worked on small RNA-mediated regulation of stem cell differentiation at the Friedrich Miescher Institute (Basel, Switzerland). As a postdoctoral researcher, I joint Cancer Research UK and the University of Cambridge (Cambridge, UK) to study the evolution of noncoding RNAs using next-generation sequencing (NGS) methods. In 2016, I became a SciLifeLab and Wallenberg fellow at the Karolinska Institute (Department of Microbiology, Tumor and Cell Biology). I am leading my independent research group at the Science for Life Laboratory (SciLifeLab) in Stockholm (Sweden).
Research description
Deciphering genome functionality
Cells do not exist in one form and adapt quickly, especially in response to metabolic changes. My group studies how this reversible cell phenotype is controlled by a sophisticated entwined interaction between RNA (long noncoding, transfer and small RNAs) and RNA-binding proteins. We have developed and used experimental and computational multi-omics approaches (bulk and single cell genomics, transcriptomics, CRISPR technology combined with cell-based assays) to understand the differences between healthy, reversible and diseased liver cell phenotypes. Our long term goal is to integrate RNA and their regulators in biomedical research not only for diagnosis and prognosis but also for therapeutic purposes.
Conference organiser
- EMBO workshop "RNA: Structure meets Function"
- Transposon symposium
- EpiChrom
- SciLifeLab seminar series
- Science & SciLifeLab prize
Teaching portfolio
BSc/MSc course
MSc courses
- Genomics for Biomedical scientist: Handle your gene expression data
- Molecular Techniques in Life Science
- Bioinformatics
- Frontiers in Translational Medicine
PhD courses
- Genomics for Biomedical scientist: Handle your gene expression data
- Non-coding RNAs, microRNAs and their role in human diseases
- The future of medicine: the role of "chance" in development, evolutionary adaptation and diseases
- Mechanisms of gene regulation in metabolism
- Molecular immunology: noncoding RNAs
- The epigenome: a platform for the integration of metabolic and signaling pathways in development and on the path to diseases
- Epigenetics and its applications in clinical research