About me

I am a MD specialized in geriatric medicine at the Catholic University of Rome, with a PhD in geriatric epidemiology from Karolinska Institutet.

I am currently an Assistant Professor in Geriatric Medicine at the Aging Research Center of Karolinska Institutet.

Research description

My main research interests are:

Multimorbidity development and its prognosis. Multimorbidity, the co-occurrence of multiple diseases in the same individual, is the most common condition encountered in older people. During the past years, I focused my attention on the definition of multimorbidity and its measurement in older individuals. Together with a group of colleagues from KI and other international Institutions, we refined the concept of multimorbidity clusters and that of speed of multimorbidity development. We investigate the impact of multimorbidity clusters on several health-related outcomes, and we recently started looking at the risk factors and determinants (i.e., psychosocial, biological etc.) of fast disease accumulation.        

Multidimensional assessment of health and biological age in older people. Aging is a complex and heterogeneous process which greatly departs from the linearity of calendar time. We combine clinical, biological, functional and socio-demographic information a) to build reliable prognostic tools for risk stratification as for example the frailty index; b) to build measures of biological and phenotypic age; c) to identify homogeneous groups of individuals with specific needs, that may benefit from given preventive and therapeutic interventions. The combination of information on disease status with functional parameters (physical and cognitive) and frailty status has been investigated in several studies I authored and co-authored.   

 

Full publication list here

Google Scholar profile here

 

Selected publications: 

Vetrano DL, Triolo F, Maggi S, Malley R, Jackson TA, Poscia A, Bernabei R, Ferrucci L, Fratiglioni L. Fostering healthy aging: the interdependency of infections, immunity and frailty. Ageing Res Rev. 2021 May 7:101351.

Grande G, Marengoni A, Vetrano DL, Roso-Llorach A, Rizzuto D, Zucchelli A, Qiu C, Fratiglioni L, Calderón-Larrañaga A. Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics. Alzheimers Dement. 2021 May;17(5):768-776. 

Calderón-Larrañaga A, Saadeh M, Hooshmand B, Refsum H, Smith AD, Marengoni A, Vetrano DL. Association of Homocysteine, Methionine, and MTHFR 677C>T Polymorphism With Rate of Cardiovascular Multimorbidity Development in Older Adults in Sweden. JAMA Netw Open. 2020 May 1;3(5):e205316.

Vetrano DL, Roso-Llorach A, Fernández S, Guisado-Clavero M, Violán C, Onder G, Fratiglioni L, Calderón-Larrañaga A, Marengoni A. Twelve-year clinical trajectories of multimorbidity in a population of older adults. Nat Commun. 2020 Jun 26;11(1):3223.

Zucchelli A, Marengoni A, Rizzuto D, Calderón-Larrañaga A, Zucchelli M, Bernabei R, Onder G, Fratiglioni L, Vetrano DL. Using a genetic algorithm to derive a highly predictive and context-specific frailty index. Aging (Albany NY). 2020 Apr 28;12(8):7561-7575.

Zucchelli A, Vetrano DL (co-first), Grande G, Calderón-Larrañaga A, Fratiglioni L, Marengoni A, Rizzuto D. Comparing the prognostic value of geriatric health indicators: a population-based study. BMC Med. 2019 Oct 2;17(1):185.

Vetrano DL, Rizzuto D, Calderón-Larrañaga A, Onder G, Welmer AK, Qiu C, Bernabei R, Marengoni A, Fratiglioni L. Walking Speed Drives the Prognosis of Older Adults with Cardiovascular and Neuropsychiatric Multimorbidity. Am J Med. 2019 May 27. pii: S0002-9343(19)30432-2.

Dekhtyar S, Vetrano DL, Marengoni A, Wang HX, Pan KY, Fratiglioni L, Calderón-Larrañaga A. Association Between Speed of Multimorbidity Accumulation in Old Age and Life Experiences: A Cohort Study. Am J Epidemiol. 2019 Sep 1;188(9):1627-1636. doi: 10.1093/aje/kwz101. PMID: 31274148.

Calderón-Larrañaga A, Vetrano DL (co-first), Ferrucci L, Mercer SW, Marengoni A, Onder G, Eriksdotter M, Fratiglioni L. Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways. J Intern Med. 2019 Mar;285(3):255-271.

Grande G, Triolo F, Nuara A, Welmer AK, Fratiglioni L, Vetrano DL. Measuring gait speed to better identify prodromal dementia. Exp Gerontol. 2019 Sep;124:110625. 

Vetrano DL, Palmer K, Marengoni A, Marzetti E, Lattanzio F, Roller-Wirnsberger R, Lopez Samaniego L, Rodríguez-Mañas L, Bernabei R, Onder G; Joint Action ADVANTAGE WP4 group. Frailty and multimorbidity: a systematic review and meta-analysis. J Gerontol A Biol Sci Med Sci. 2018 May 3.

Vetrano DL, Rizzuto D, Calderón-Larrañaga A, Onder G, Welmer AK, Bernabei R, Marengoni A, Fratiglioni L. Trajectories of functional decline in older adults with neuropsychiatric and cardiovascular multimorbidity: A Swedish cohort study. PLoS Med. 2018 Mar 6;15(3):e1002503.

Calderón-Larrañaga A, Vetrano DL (co-first), Onder G, Gimeno-Feliu LA, Coscollar-Santaliestra C, Carfí A, Pisciotta MS, Angleman S, Melis RJ, Santoni G, Mangialasche F, Rizzuto D, Welmer AK, Bernabei R, Prados-Torres A, Marengoni A, Fratiglioni L. Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization. J Gerontol A Biol Sci Med Sci. 2016 Dec 21. pii: glw233.

Vetrano DL, Tosato M, Colloca G, Topinkova E, Fialova D, Gindin J, van der Roest HG, Landi F, Liperoti R, Bernabei R, Onder G; SHELTER Study. Polypharmacy in nursing home residents with severe cognitive impairment: results from the SHELTER Study. Alzheimers Dement. 2013 Sep;9(5):587-93.

Vetrano DL, Landi F, Volpato S, Corsonello A, Meloni E, Bernabei R, Onder G. Association of sarcopenia with short- and long-term mortality in older adults admitted to acute care wards: results from the CRIME study. J Gerontol A Biol Sci Med Sci. 2014 Sep;69(9):1154-61.

Teaching portfolio

As part of my pedagogical activity, I have been lecturing to both masters' and PhD students. I have also been a supervisor of several MD students and residents in geriatrics. I am currently co-supervising two PhD students and supervising several masters' students and research assistants. 

Education

- 2019 PhD in Geriatric Epidemiology

- 2016 Specialization in Geriatrics

- 2010 Medical Doctor degree

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