Dr. Frederick A. Zeiler

Frederick Zeiler

Affiliated to research

Dr. Zeiler is an affiliated research in the Dept of Clinical Neurosciences who specializes in biosignal analytics, time series modelling and biomedical engineering approaches in traumatic brain injury

About me

Frederick Zeiler is a Canadian neurosurgeon who is currently an Associate Professor in the Depts of Surgery, Human Anatomy and Cell Science, and Biomedical Engineering at the University of Manitoba (UM), and the endowed Professor of Neuroscience at the Rady Faculty of Health Science at the UM. He is also an affiliated researcher with the Dept of Clinical Neuroscience at the KI. He completed his bachelor of science degree at UM, focused on applied mathematics and physical chemistry. He went on to complete his medical school at UM, followed by his neurosurgery residency at the same institution, receiving certification in neurosurgery from the Royal College of Surgeons of Canada. Dr. Zeiler has also completed dedicated fellowship training in both neurocritical care at the Montreal Neurological Institute, and the Royal College of Physicians and Surgeons of Canada (RCPSC) clinician investigator program at UM. Finally, he completed his PhD training at the University of Cambridge, with his studies focused on advanced multi-modal monitoring of cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI), under the supervision of world experts in TBI research: professors David Menon and Marek Czosnyka. During his time in Cambridge, he was recognized as both a Royal College of Surgeons of Canada Travelling Fellow in Surgery and University of Cambridge International Trust Scholar for the entirety of his studies. Dr. Zeiler is the author of over 320 peer-reviewed manuscripts, abstracts and textbook chapter publications, and recipient of numerous awards for academic accomplishments.

Research description

Dr. Zeiler leads the Winnipeg Acute TBI Laboratories at Health Sciences Centre in Winnipeg. His research program is focused on the application of multi-modal invasive/non-invasive cranial physiologic monitoring for the continuous assessment of cerebral autoregulation, compensatory reserve, autonomics and signal entropy. This program integrates complex high-frequency signal processing, with neuroimaging, serum/CSF/microdialysis protein and genetic biomarkers. The goal is to uncover the molecular mechanisms involved in impaired cerebrovascular reactivity in TBI, leading to the development of potential therapeutic targets directed at prevention and treatment of vascular dysfunction in TBI. His lab is funded through a variety of local, national and international sources, including: the Manitoba Public Insurance (MPI) Neuroscience Research Endowment/Operating Fund, Canadian Institutes of Health Research (CIHR), Canada Foundation for Innovation (CFI), the National Institutes of Health (NIH) and the Natural Sciences and Engineering Research Council of Canada (NSERC).


  • PhD (cerebrovascular physiology in TBI), University of Cambridge 
  • Certification (clinician-investigator), Royal College of Physicians and Surgeons of Canada
  • Fellowship (clinician-investigator), University of Manitoba 
  • Certification/Fellowship (neurosurgery), Royal College of Physicians and Surgeons of Canada
  • Fellowship (neurocritical care), Montreal Neurological Institute, McGill 
  • Residency (neurosurgery), University of Manitoba
  • Medical Doctorate, University of Manitoba
  • Primary Care Paramedic, CritCare Paramedic Academy
  • Bachelor of Science, University of Manitoba

Academic honours, awards and prizes

  • Manitoba Public Insurance (MPI) Professorship in Neuroscience (Endowed University Professorship) (2022-Present)
  • Falconer Rh Award, Winnipeg Rh Institute Foundation, University of Manitoba (2020)
  • Centre on Aging Fellowship, University of Manitoba (2020)
  • Rudy Falk Clinician-Scientist Professorship, University of Manitoba (2019 – 2022)
  • Cambridge International Trust Scholar, University of Cambridge (2016-2019)
  • Harry S. Morton Travelling Fellow in Surgery, Royal College of Physicians and Surgeons of Canada (2016-17; 2017-18)
  • R. Samuel McLaughlin Fellowship, Manitoba Medical Service Foundation/University of Manitoba (2016)