Jan-Bernd Stukenborg
Senior lecturer
About me
I am working right now as senior lecturer and group leader (NORDFERTIL research lab Stockholm) at the Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden. In addtion to my work as group leader, I am the research coordinator of NORDFERTIL (www.nordfertil.org).
Research description
Main research areas:
- Germ cell differentiation in vivo and in vitro.
- Fertility preservation techniques in children with gonadal dysfunctions.
- Experiments on in vitro differentiation techniques include novel cell culture approaches with human and animal gonadal cells as well as human embryonic and human induced pluripotent stem cells (hESCs and hiPSCs).
Teaching portfolio
Ongoing supervision of a PhD candidate:
1) Yanhua Cui, Karolinska Institutet
Title: “Novel strategies to preserve future fertility in boys and men.”
Registration: 2018-09-11
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden); co-supervision: Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden), Michael Landreh, PhD (Karolinska Institutet
2) Hajar Ali Mohammed Ba Omar, Karolinska Institutet
Title: “Effects of haematological and oncological diseases on spermatogonial stem cell populations in boys.”
Registration: 2018-09-04
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden); co-supervision: Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden), Nikolas Herold, MD (Karolinska Institutet)
3) Yifan Yang, Karolinska Institutet
Title: “Effects of medical treatments of gonadal development in boys and men.”
Registration: 2020-01-15
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden); co-supervision: Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden); Jingtao Guo, PhD (University of Utah, USA)
4) Femke Harteveld, Karolinska Institutet
Title: “Macrophages and the testicular microenvironment in humans.”
Registration: 2020-10-10
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden); co-supervision: Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden); Susana Chuva de Sousa Lopes, PhD (University of Leiden, The Netherlands)
Ongoing supervision of a PhD candidate as co-supervisor:
1) Ieva Masliukaite, University of Amsterdam, The Netherlands
Title: “Propagation of human SSCs”.
Registration: 2015-10-20; main supervisor: Sjoerd Repping, MD, PhD (University of Amsterdam, The Netherlands), co-supervision: Ans M. M. van Pelt, PhD (University of Amsterdam, The Netherlands), Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden).
2) Melanie Poganitsch-Korhonen, University of Helsinki, Finland;
Title: “Male fertility, late morbidity and ageing after childhood cancer” Registration: 2014-09-24; main supervisor Kirsi Jahnukainen, MD, PhD (University of Helsinki, Finland), co-supervision: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
3) Bethel Embiae, Karolinska Institutet
Title: "Functional characterization and targeting of neuroblastoma cell of origin"
Registration: 2021-01.20; main supervisor: Ninib Baryawno, PhD (Karolinska Institutet); co-supervision: John Inge Johnson, PhD (Karolinska Institutet), Malin Wickström Näsman, PhD (Karolinska Institutet), Jan-Bernd Stukenborg, PhD (Karolinska Institutet)
PhD candidates supervised up to the defence of the candidate’s doctoral thesis:
1) Magdalena Kurek, Karolinska Institutet
Title: “Human induced pluripotent stem cells differentiation towards the male germ cell lineage.”
Registration: 2015-01-19; halftime seminar: 2017-05-31; defence: 2019-10-25
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden); co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden), Sarita Panula, PhD (Karolinska Institutet), Rod Mitchell, MD, PhD (University Edinburgh, UK)
2) Halima Al-Balushi, Karolinska Institutet
Title: “In vitro models aiming for fertility preservation.”
Registration: 2014-04-22; halftime seminar: 2016-08-31; defence: 2018-11-16
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden); co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden); Outi Hovatta, MD, PhD (Karolinska Institutet, Sweden); Elisabet Åkesson, MD, PhD (Karolinska Institutet, Sweden)
3) Joao Pedro Alves Lopes, Karolinska Institutet
Title: “Novel culture systems to model testicular function and organization.” Registration: 2015-01-19; halftime seminar: 2017-06-07; defense: 2018-08-31
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden); co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden), Ellen Goossens, PhD (VUB, Belgium)
4) Mina Nikolova Mincheva, University of Münster, Germany
Title: “Interaction of male gonadal cell types in differentiation cell culture” Registration: 2015-01-01; defense: 2018-03-15
main supervisor: Stefan Schlatt, PhD (University of Münster, Germany), co-supervision: Sylvia Kaiser, PhD (University of Münster, Germany), Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
5) Ahmed Reda, Karolinska Institutet
Title: “Artificial testis to study early gonadal development and germ cell differentiation.”
Registration: 2012-04-24; halftime seminar: 2014-06-03; defence: 2016-09-30; main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden); co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden); Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden & University of Helsinki, Finland
6) Sarita Panula, Karolinska Institutet
Title: “Differentiation and charaterization of human iPSC derived germ cells and the derivation of patient specific iPSC lines for the study of infertility.” Registration: 2009-11-12; halftime seminar: 2012-09-18; defence: 2015-06-09; main supervisor: Outi Hovatta, MD, PhD (Karolinska Institutet, Sweden); co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden); Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden), Renee Reijo Pera (Stanford University, USA)
Education
COURSES AND DEGREES
2001 - 2005 - Study of Biology, Westphalian Wilhelms University (WWU), Münster Germany
2005 - Diploma-thesis (Master Thesis; Biology), Centre of Reproductive Medicine and Andrology (CeRA), WWU, Münster, Germany & University of Pittsburgh, USA
2005 - 2009 - Ph.D.-studies (Biology), CeRA, WWU, Münster, Germany
DOCTORAL DEGREE
2009 - Biology (Reproductive Biology), Title: “In vitro differentiation of male germ cells.” CeRA, WWU, Münster, Germany; PhD supervision: Prof. Dr. E. Liebau; Prof. Dr. S. Schlatt
POSTDOC APPOINTMENTS
2009 – 2013 - Post-Doc at the Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Karolinska Institutet; supervision: Prof. Dr. Olle Söder
DOCENT-LEVEL COMPETENCE
2016 - Docent in Reproductive Biology; Karolinska Institutet