Jens Hjerling-Leffler
Principal researcher
About me
Current position: Assistant Professor and Principle Investigator
Main interests: Circuit maturation, neuronal diversity, mouse genetics, single-cell sequencing, transcriptional regulation, electrophysiology and virus based tools.
Previous research appointments
Fishell lab, NYU Langone Medical Center, New York, NY, US Koltzenburg lab, Queen Square Centre for Neuromuscular Disease, UCL, London, UK Ernfors lab, Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden Pfrieger lab, Max Delbrück Center for Molecular Medicine, Berlin, Germany
Research description
Our research group is interested in the genetic and cellular mechanisms of the maturation and function of the brain's inhibitory system. We apply advanced mouse genetics in combination with electrophysiology and modern molecular methods to probe the function of individual cell types as well as study the circuit basis of their function.
Education
Post-doctoral fellow, NYU Langone Medical Center, New York, NY, US
Post-doctoral fellow, Institute of Child Health, UCL, London, UK
PhD, Medical Biochemistry, Karolinska Institutet, Sweden
Undergraduate education, Lund University, Sweden
Academic honours, awards and prizes
Selected Publications
Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells.
Keimpema E, Straiker A, Mackie K, Harkany T, Hjerling-Leffler J.
J. Physiol. 2012
The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors.
*Lee S, *Hjerling-Leffler J, Zagha E, Fishell G, Rudy B.
J Neurosci. 2010
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons.
Rudy B, Fishell G, Lee S, Hjerling-Leffler J.
Dev Neurobiol. 2011
Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons.
*Miyoshi G, *Hjerling-Leffler J, Karayannis T, Sousa VH, Butt SJ, Battiste J, Johnson JE, Machold RP, Fishell G.
J Neurosci. 2010
The cell-intrinsic requirement of Sox6 for cortical interneuron development.
Batista-Brito R, Rossignol E, Hjerling-Leffler J, Denaxa M, Wegner M, Lefebvre V, Pachnis V, Fishell G.
Neuron. 2009
Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.
Andäng M, Hjerling-Leffler J, Moliner A, Lundgren TK, Castelo-Branco G, Nanou E, Pozas E, Bryja V, Halliez S, Nishimaru H, Wilbertz J, Arenas E, Koltzenburg M, Charnay P, El Manira A, Ibañez CF, Ernfors P.
Nature. 2008