Johan Lundkvist

Publications
CV
Public outreach and news

Articles

Article: NEUROSCIENCE RESEARCH. 2016;109:9-15

Endogenous APP accumulates in synapses after BACE1 inhibition.

Nigam SM; Xu S; Ackermann F; Gregory JA; Lundkvist J; Lendahl U; Brodin L
Article: JOURNAL OF NEUROCHEMISTRY. 2015;132(4):477-486

Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.

Georgievska B; Gustavsson S; Lundkvist J; Neelissen J; Eketjäll S; Ramberg V; Bueters T; Agerman K; Juréus A; Svensson S; Berg S; Fälting J; Lendahl U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(3):1540-1550

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions.

Olsson F; Schmidt S; Althoff V; Munter LM; Jin S; Rosqvist S; Lendahl U; Multhaup G; Lundkvist J
Article: FEBS OPEN BIO. 2014;4:393-406

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.

Wanngren J; Lara P; Ojemalm K; Maioli S; Moradi N; Chen L; Tjernberg LO; Lundkvist J; Nilsson I; Karlström H
Article: FRONTIERS IN PHARMACOLOGY. 2014;5:102

The battle of Alzheimer's Disease - the beginning of the future Unleashing the potential of academic discoveries.

Lundkvist J; Halldin MM; Sandin J; Nordvall G; Forsell P; Svensson S; Jansson L; Johansson G; Winblad B; Ekstrand J
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2013;69(6):1247-1260

Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data.

Niva C; Parkinson J; Olsson F; van Schaick E; Lundkvist J; Visser SAG
Article: JOURNAL OF NEUROSCIENCE. 2012;32(48):17297-17305

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.

Borgegård T; Gustavsson S; Nilsson C; Parpal S; Klintenberg R; Berg A-L; Rosqvist S; Serneels L; Svensson S; Olsson F; Jin S; Yan H; Wanngren J; Jureus A; Ridderstad-Wollberg A; Wollberg P; Stockling K; Karlström H; Malmberg A; Lund J; Arvidsson PI; De Strooper B; Lendahl U; Lundkvist J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(39):32640-32650

Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.

Wanngren J; Ottervald J; Parpal S; Portelius E; Strömberg K; Borgegård T; Klintenberg R; Juréus A; Blomqvist J; Blennow K; Zetterberg H; Lundkvist J; Rosqvist S; Karlström H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(15):11810-11819

First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.

Borgegard T; Juréus A; Olsson F; Rosqvist S; Sabirsh A; Rotticci D; Paulsen K; Klintenberg R; Yan H; Waldman M; Stromberg K; Nord J; Johansson J; Regner A; Parpal S; Malinowsky D; Radesater A-C; Li T; Singh R; Eriksson H; Lundkvist J
Article: CHEMMEDCHEM. 2012;7(3):396-399

Sulfonimidamides as sulfonamides bioisosteres: rational evaluation through synthetic, in vitro, and in vivo studies with γ-secretase inhibitors.

Sehgelmeble F; Janson J; Ray C; Rosqvist S; Gustavsson S; Nilsson LI; Minidis A; Holenz J; Rotticci D; Lundkvist J; Arvidsson PI
Article: PLOS ONE. 2012;7(2):e31084

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system.

Mattsson N; Rajendran L; Zetterberg H; Gustavsson M; Andreasson U; Olsson M; Brinkmalm G; Lundkvist J; Jacobson LH; Perrot L; Neumann U; Borghys H; Mercken M; Dhuyvetter D; Jeppsson F; Blennow K; Portelius E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(12):8527-8536

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J; Frånberg J; Svensson AI; Laudon H; Olsson F; Winblad B; Liu F; Näslund J; Lundkvist J; Karlström H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;393(1):21-27

Evidence for dimeric BACE-mediated APP processing.

Jin S; Agerman K; Kolmodin K; Gustafsson E; Dahlqvist C; Jureus A; Liu G; Fälting J; Berg S; Lundkvist J; Lendahl U
Article: JOURNAL OF NEUROCHEMISTRY. 2005;95(3):880-890

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628

Hypoxia requires notch signaling to maintain the undifferentiated cell state.

Gustafsson MV; Zheng X; Pereira T; Gradin K; Jin S; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Article: NEUROSCIENCE LETTERS. 2005;378(1):59-64

Overexpression of calsenilin enhances gamma-secretase activity.

Jo D-G; Jang J; Kim B-J; Lundkvist J; Jung Y-K
Article: JOURNAL OF NEUROCHEMISTRY. 2005;92(5):1010-1020

Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.

Hansson EM; Strömberg K; Bergstedt S; Yu G; Näslund J; Lundkvist J; Lendahl U
Article: GENESIS. 2005;41(1):13-22

Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.

Lundkvist J; Zhu S; Hansson EM; Schweinhardt P; Miao Q; Beatus P; Dannaeus K; Karlström H; Johansson CB; Viitanen M; Rozell B; Spenger C; Mohammed A; Kalimo H; Lendahl U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(44):45564-45572

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity.

Bergman A; Laudon H; Winblad B; Lundkvist J; Näslund J
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2004;12(10):813-819

Detection of the founder effect in Finnish CADASIL families.

Mykkänen K; Savontaus M-L; Juvonen V; Sistonen P; Tuisku S; Tuominen S; Penttinen M; Lundkvist J; Viitanen M; Kalimo H; Pöyhönen M
Article: ACTA NEUROPATHOLOGICA. 2004;108(1):69-80

Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse.

Oprica M; Van Dam A-M; Lundkvist J; Iverfeldt K; Winblad B; Bartfai T; Schultzberg M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):23925-23932

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.

Laudon H; Karlström H; Mathews PM; Farmery MR; Gandy SE; Lundkvist J; Lendahl U; Näslund J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(16):16744-16753

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin.

Bergman A; Hansson EM; Pursglove SE; Farmery MR; Lannfelt L; Lendahl U; Lundkvist J; Näslund J
Article: JOURNAL OF NEUROCHEMISTRY. 2004;89(1):44-53

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.

Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(6):4144-4152

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex.

Lee S-F; Shah S; Yu C; Wigley WC; Li H; Lim M; Pedersen K; Han W; Thomas P; Lundkvist J; Hao Y-H; Yu G
Article: EXPERIMENTAL CELL RESEARCH. 2003;287(1):1-9

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

Bergman A; Religa D; Karlström H; Laudon H; Winblad B; Lannfelt L; Lundkvist J; Näslund J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):17119-17124

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

Karlström H; Beatus P; Dannaeus K; Chapman G; Lendahl U; Lundkvist J
Article: JOURNAL OF NEUROTRAUMA. 2002;19(8):939-951

Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist.

Tehranian R; Andell-Jonsson S; Beni SM; Yatsiv I; Shohami E; Bartfai T; Lundkvist J; Iverfeldt K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(6):4014-4019

Notch receptor cleavage depends on but is not directly executed by presenilins.

Taniguchi Y; Karlström H; Lundkvist J; Mizutani T; Otaka A; Vestling M; Bernstein A; Donoviel D; Lendahl U; Honjo T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(9):6763-6766

A sensitive and quantitative assay for measuring cleavage of presenilin substrates.

Karlström H; Bergman A; Lendahl U; Näslund J; Lundkvist J
Article: MECHANISMS OF DEVELOPMENT. 2001;104(1-2):3-20

The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity.

Beatus P; Lundkvist J; Oberg C; Pedersen K; Lendahl U
Article: AMERICAN JOURNAL OF PATHOLOGY. 2001;158(3):817-823

Expression of the intermediate filament nestin in gastrointestinal stromal tumors and interstitial cells of Cajal.

Tsujimura T; Makiishi-Shimobayashi C; Lundkvist J; Lendahl U; Nakasho K; Sugihara A; Iwasaki T; Mano M; Yamada N; Yamashita K; Toyosaka A; Terada N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(21):11534-11539

Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice.

Vezzani A; Moneta D; Conti M; Richichi C; Ravizza T; De Luigi A; De Simoni MG; Sperk G; Andell-Jonsson S; Lundkvist J; Iverfeldt K; Bartfai T
Article: DEVELOPMENT. 1999;126(17):3925-3935

The notch 3 intracellular domain represses notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters.

Beatus P; Lundkvist J; Oberg C; Lendahl U
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1999;276(3):R644-R651

Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist.

Lundkvist J; Sundgren-Andersson AK; Tingsborg S; Ostlund P; Engfors C; Alheim K; Bartfai T; Iverfeldt K; Schultzberg M
Article: EUROPEAN CYTOKINE NETWORK. 1998;9(3):279-288

Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta.

Anforth HR; Bluthe RM; Bristow A; Hopkins S; Lenczowski MJ; Luheshi G; Lundkvist J; Michaud B; Mistry Y; Van Dam AM; Zhen C; Dantzer R; Poole S; Rothwell NJ; Tilders FJ; Wollman EE
Article: FEBS LETTERS. 1998;429(3):307-311

Human/mouse interleukin-1 receptor/receptor accessory protein interactions in IL-1beta-induced NFkappaB activation.

Layé S; Lundkvist J; Bartfai T
Article: FEBS LETTERS. 1998;429(3):299-302

Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor.

Malinowsky D; Lundkvist J; Layé S; Bartfai T
Article: EUROPEAN CYTOKINE NETWORK. 1998;9(2):131-138

Interleukin-1-mediated febrile responses in mice and interleukin-1 beta activation of NFkappaB in mouse primary astrocytes, involves the interleukin-1 receptor accessory protein.

Zetterström M; Lundkvist J; Malinowsky D; Eriksson G; Bartfai T
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1996;309(2):195-200

A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity.

Lundkvist J; Chai Z; Teheranian R; Hasanvan H; Bartfai T; Jenck F; Widmer U; Moreau JL
Article: CYTOKINE. 1996;8(3):227-237

Subchronic glucocorticoid pretreatment reversibly attenuates IL-beta induced fever in rats; IL-6 mRNA is elevated while IL-1 alpha and IL-1 beta mRNAs are suppressed, in the CNS.

Chai Z; Alheim K; Lundkvist J; Gatti S; Bartfai T
Article: NEUROSCIENCE LETTERS. 1995;200(2):121-124

cDNA sequence, ligand biding, and regulation of galanin/GMAP in mouse brain.

Lundkvist J; Land T; Kahl U; Bedecs K; Bartfai T
Article: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 1995;15(8):721-729

Interleukin-1 receptor antagonist protein and mRNA in the rat adrenal gland.

Schultzberg M; Tingsborg S; Nobel S; Lundkvist J; Svenson S; Simoncsits A; Bartfai T
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All other publications

Review: CURRENT OPINION IN PHARMACOLOGY. 2007;7(1):112-118

Gamma-secretase: a complex target for Alzheimer's disease.

Lundkvist J; Näslund J
Review: TRENDS IN NEUROSCIENCES. 2001;24(9):492-494

Notch and the birth of glial cells.

Lundkvist J; Lendahl U

Employments

Affiliated to Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2022-2024

Degrees and Education

Docent, Karolinska Institutet, 2005

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