Konstantinos Chiotis

About me

My research interest lies in obtaining a deeper understanding of the proteinopathies, which lead to neurodegeneration with the use of advanced neuroimaging techniques and fluid biomarkers. My research work so far has focussed on Alzheimer's disease and other causes of dementia. As a physician, I am particularly interested in the incorporation of validated biomarkers to clinical practice for the purpose of diagnosis at the early stages of the disease, as well as evaluation of therapeutic efficacy for disease-modifying therapies.

Research description

Imaging tau pathology in vivo in patients with Alzheimer's disease and other proteinopathies

• Evaluation and comparison of the binding characteristics of different PET tracers in vivo in Alzheimer's disease and other tauopathies.
• Assessment of the association between tau pathology, amyloid-beta deposition, neurodegeneration and cognitive impairment in vivo.
• Investigation of longitudinal changes in the binding load and pattern of a tau PET tracer.

Evaluation of the relationship between measures of amyloid-beta and tau pathologies with PET and cerebrospinal fluid in patients with Alzheimer's disease.

Assessment of the clinical validity of amyloid-beta PET imaging in routine clinical patients with cognitive impairment.

Neuroinflammation in neurodegenerative diseases.

• Evaluation of astrocyte activation in patients with sporadic and autosomal dominant Alzheimer's disease, as well as frontotemporal lobar degeneration.
• Assessment of association between astrocyte activation and neurodegeneration in vivo.

 

Teaching portfolio

Bedside teaching/supervision of medical students. jan. 2018 - Present Karolinska University Hospital Solna, Theme Neurology, Department of Neurology, Stockholm, Sweden

• Teaching of neurological status examination.
• Supervision at neurological inpatient and outpatient clinics, and at the emergency department.

 

Lecture on molecular imaging of tau in Alzheimer's disease - PhD course May 2016, March 2020 Karolinska Institutet, Center for Alzheimer research, Stockholm, Sweden

 

Lecture on positron emission tomography - Specialist course in neuropsychology Apr. 2016 Stockholm university, Department of psychology, Stockholm, Sweden

 

Samson Nivins - Msc thesis Feb. 2015 - Jul. 2015 Karolinska Institutet, Center for Alzheimer research, Stockholm, Sweden

• Msc in Biomedical Engineering, VIT University, Vellore, India.
• Thesis title: Comparative analysis of cerebral glucose metabolism in MCI and AD using [18F]FDG-PET

Education

Postdoctoral fellow Jan. 2018 - Present Karolinska Institutet, Center for Alzheimer research, Stockholm, Sweden

• Supervisor: Dr. Agneta Nordberg

 

Neurology resident physician Jan. 2018 - Present Karolinska University Hospital Solna, Theme Neurology, Department of Neurology, Stockholm, Sweden

• Clinical rotations at different neurological wards with a focus on stroke, general neurology, spinal cord injury, and clinical work at the the acute neurology ward with neuromonitoring.
• Clinical work at the neurology outpatient clinic with focus on movement disorders. Staffing of the neurology emergency clinic.
• Clinical supervisor: Dr. Anders Johansson (former supervisor: Dr. Faiez Al Nimer)

 

Doctor of Philosophy (PhD) Oct. 2013 - Dec. 2017 Karolinska Institutet, Center for Alzheimer research, Stockholm, Sweden

• Thesis title: Molecular imaging of tau in the pathological cascade of Alzheimer’s disease.
• Supervisors: Prof. Agneta Nordberg (Karolinska Institutet), Prof. Ove Almkvist (Karolinska Institutet and Stockholm University), Dr. Laure Saint-Aubert (Karolinska Institutet and Universitaire de Toulouse), and Dr. Stephen Carter (University of Manchester).
• Opponent: Prof. Gil Rabinovici (University of California, San Fransisco).

 

Medical Doctor (MD) Nov. 2005 - Nov. 2011 University of Patras, Medical faculty, Patras, Greece

• Clinical rotations in different departments at University Hospital of Patras (Greece) and at Health Sciences Center, University of New Mexico (USA).