Magnus Schou

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About me

Magnus Schou is Adjunct Professor of Medical Radiochemistry at the Department
of Clinical Neuroscience, Karolinska Institutet.

Articles

Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020;59(32):13490-13495

Transition-Metal-Free Carbon Isotope Exchange of Phenyl Acetic Acids.

Destro G; Horkka K; Loreau O; Buisson D-A; Kingston L; Del Vecchio A; Schou M; Elmore CS; Taran F; Cantat T; Audisio D
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(12):1756-1761

Synthesis and Preclinical Evaluation of 6-[18F]Fluorine-α-methyl-l-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake.

Krasikova R; Kondrashov M; Avagliano C; Petukhov M; Vazquez-Romero A; Revunov E; Johnström P; Tari L; Tóth M; Häggkvist J; Erhardt S; Cervenka S; Schou M
Article: EJNMMI RESEARCH. 2020;10(1):59

Quantification and reliability of [11C]VC - 002 binding to muscarinic acetylcholine receptors in the human lung - a test-retest PET study in control subjects.

Cselényi Z; Jucaite A; Kristensson C; Stenkrona P; Ewing P; Varrone A; Johnström P; Schou M; Vazquez-Romero A; Moein MM; Bolin M; Siikanen J; Grybäck P; Larsson B; Halldin C; Grime K; Eriksson UG; Farde L
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(9):1245-1249

First Radiolabeling of a Ganglioside with a Positron Emitting Radionuclide: In Vivo PET Demonstrates Low Exposure of Radiofluorinated GM1 in Non-human Primate Brain.

Revunov E; Johnström P; Arakawa R; Malmquist J; Jucaite A; Defay T; Takano A; Schou M
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(7):1048-1057

Synthesis, Biodistribution, and Radiation Dosimetry of a Novel mGluR5 Radioligand: 18F-AZD9272.

Nag S; Varnäs K; Arakawa R; Jahan M; Schou M; Farde L; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2020;40(4):799-807

A PET study in healthy subjects of brain exposure of 11C-labelled osimertinib - A drug intended for treatment of brain metastases in non-small cell lung cancer.

Varrone A; Varnäs K; Jucaite A; Cselényi Z; Johnström P; Schou M; Vazquez-Romero A; Moein MM; Halldin C; Brown AP; Vishwanathan K; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2020;63(3):100-107

"In-loop" carbonylation-A simplified method for carbon-11 labelling of drugs and radioligands.

Ferrat M; Dahl K; Halldin C; Schou M
Article: JOURNAL OF ORGANIC CHEMISTRY. 2019;84(24):16076-16085

Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling.

Sardana M; Bergman J; Ericsson C; Kingston LP; Schou M; Dugave C; Audisio D; Elmore CS
Article: EJNMMI RESEARCH. 2019;9(1):100

Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity.

Lindberg A; Arakawa R; Nogami T; Nag S; Schou M; Elmore CS; Farde L; Pike VW; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2019;78-79:11-16

Development of a 18F-labeled PET radioligand for imaging 5-HT1B receptors: [18F]AZ10419096.

Lindberg A; Nag S; Schou M; Arakawa R; Nogami T; Moein MM; Elmore CS; Pike VW; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2019;62(6):265-279

Synthesis, 3 H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2.

Artelsmair M; Miranda-Azpiazu P; Kingston L; Bergare J; Schou M; Varrone A; Elmore CS
Article: NUCLEAR MEDICINE AND BIOLOGY. 2019;70:1-13

Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors.

Lindberg A; Lu S; Nag S; Schou M; Liow J-S; Zoghbi SS; Frankland MP; Gladding RL; Morse CL; Takano A; Amini N; Elmore CS; Lee YS; Innis RB; Halldin C; Pike VW
Article: CHEMISTRYSELECT. 2019;4(6):1846-1849

Rapid and Efficient Synthesis of ¹¹C-Labeled Benzimidazolones Using [¹¹C]Carbon Dioxide

Horkka K; Dahl K; Bergare J; Elmore CS; Halldin C; Schou M
Article: EJNMMI RESEARCH. 2019;9(1):9

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator.

Schou M; Ewing P; Cselenyi Z; Fridén M; Takano A; Halldin C; Farde L
Article: EJNMMI RESEARCH. 2018;8(1):113

The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass.

Jahan M; Johnström P; Selvaraju RK; Svedberg M; Winzell MS; Bernström J; Kingston L; Schou M; Jia Z; Skrtic S; Johansson L; Korsgren O; Farde L; Halldin C; Eriksson O
Article: ACS CHEMICAL NEUROSCIENCE. 2018;9(11):2542-2547

Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy.

Cairns AG; Vazquez-Romero A; Mahdi Moein M; Ådén J; Elmore CS; Takano A; Arakawa R; Varrone A; Almqvist F; Schou M
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2018;57(31):9744-9748

Late-Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO2.

Del Vecchio A; Caillé F; Chevalier A; Loreau O; Horkka K; Halldin C; Schou M; Camus N; Kessler P; Kuhnast B; Taran F; Audisio D
Article: ACS CHEMICAL NEUROSCIENCE. 2018;9(5):906-911

Development of [ Carbonyl-11C]AZ13198083, a Novel Histamine Type-3 Receptor Radioligand with Favorable Kinetics.

Dahl K; Nakao R; Amini N; Moein MM; Finnema S; Malmquist J; Varnäs K; Schou M
Article: CHEMICAL COMMUNICATIONS. 2018;54(34):4286-4289

[18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling.

Cortés González MA; Nordeman P; Bermejo Gómez A; Meyer DN; Antoni G; Schou M; Szabó KJ
Article: ACS CHEMICAL NEUROSCIENCE. 2018;9(2):224-229

Discovery of a Novel Muscarinic Receptor PET Radioligand with Rapid Kinetics in the Monkey Brain.

Malmquist J; Varnäs K; Svedberg M; Vallée F; Albert JS; Finnema SJ; Schou M
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2017;60(13):624-628

Reduction of [11 C]CO2 to [11 C]CO using solid supported zinc.

Dahl K; Ulin J; Schou M; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2017;54:34-40

[11C]AZ10419096 - a full antagonist PET radioligand for imaging brain 5-HT1B receptors.

Lindberg A; Nag S; Schou M; Takano A; Matsumoto J; Amini N; Elmore CS; Farde L; Pike VW; Halldin C
Article: JOURNAL OF FLUORINE CHEMISTRY. 2017;194:51-57

Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

Gome AB; Gonzalez MAC; Lubcke M; Johansson MJ; Schou M; Szabo KJ
Article: CHEMICAL COMMUNICATIONS. 2016;52(97):13963-13966

Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides.

Gómez AB; Cortés González MA; Lübcke M; Johansson MJ; Halldin C; Szabó KJ; Schou M
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2016;358(3):464-471

Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676.

Varnäs K; Juréus A; Johnström P; Ahlgren C; Schött P; Schou M; Gruber S; Jerning E; Malmborg J; Halldin C; Afzelius L; Farde L
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2016;2016(16):2775-2777

Direct and Efficient (Carbonyl)cobalt-Mediated Aryl Acetylation Using [¹¹C] Methyl Iodide

Dahl K; Schou M; Halldin C
Article: ACS CHEMICAL NEUROSCIENCE. 2016;7(2):177-184

Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor.

Schou M; Varnäs K; Jureus A; Ahlgren C; Malmquist J; Häggkvist J; Tari L; Wesolowski SS; Throner SR; Brown DG; Nilsson M; Johnström P; Finnema SJ; Nakao R; Amini N; Takano A; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2015;58(5):220-225

An evaluation of a high-pressure (11)CO carbonylation apparatus.

Dahl K; Itsenko O; Rahman O; Ulin J; Sjöberg C-O; Sandblom P; Larsson L-A; Schou M; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(10):pyv036

Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates.

Schou M; Varnäs K; Lundquist S; Nakao R; Amini N; Takano A; Finnema SJ; Halldin C; Farde L
Article: RSC ADVANCES. 2015;5(108):88886-88889

¹¹C-carbonylation reactions using gas-liquid segmented microfluidics

Dahl K; Schou M; Ulin J; Sjoberg C-O; Farde L; Halldin C
Article: EJNMMI RESEARCH. 2014;4(1):50-8

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain.

Fridén M; Wennerberg M; Antonsson M; Sandberg-Ställ M; Farde L; Schou M
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2014;98:140-143

Determination of plasma protein binding of positron emission tomography radioligands by high-performance frontal analysis.

Amini N; Nakao R; Schou M; Halldin C
Article: MOLECULAR IMAGING AND BIOLOGY. 2014;16(2):173-179

Synthesis, radiolabeling, and in vivo pharmacokinetic evaluation of the amyloid beta radioligand [11C]AZD4694 in nonhuman primates.

Schou M; Varnäs K; Sandell J; Johnström P; Cselenyi Z; Svensson S; Nakao R; Amini N; Bergman L; Sumic A; Gulyas B; Lindström-Böö E; Halldin C; Farde L
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2014;2014(2):307-310

Improved Yields for the Palladium-Mediated ¹¹C-Carbonylation Reaction Using Microwave Technology

Dahl K; Schou M; Rahman O; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2013;40(3):410-414

Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate.

Schou M; Varnäs K; Jucaite A; Gulyás B; Halldin C; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(4):580-593

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients.

Forsberg A; Juréus A; Cselényi Z; Eriksdotter M; Freund-Levi Y; Jeppsson F; Swahn B-M; Sandell J; Julin P; Schou M; Andersson J; Johnström P; Varnäs K; Halldin C; Farde L; Svensson S
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2013;2013(7):1228-1231

Palladium-Mediated [¹¹C]Carbonylation at Atmospheric Pressure: A General Method Using Xantphos as Supporting Ligand

Dahl K; Schou M; Amini N; Halldin C
Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2013;405(4):1303-1310

Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28.

Amini N; Nakao R; Schou M; Halldin C
Article: JOURNAL OF CHROMATOGRAPHY A. 2012;1266:76-83

Rapid metabolite analysis of positron emission tomography radioligands by direct plasma injection combining micellar cleanup with high submicellar liquid chromatography with radiometric detection.

Nakao R; Schou M; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2012;55(13):460-462

Radiolabeling of two 11C-labeled formylating agents and their application in the preparation of [11C]benzimidazole

Schou M; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2012;55(13):455-459

Radiofluorination and reductive amination using a microfluidic device

Dahl K; Schou M; Halldin C
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2012;22(13):4332-4337

Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹⁸F-PET imaging agents for β-amyloid plaques.

Swahn B-M; Sandell J; Pyring D; Bergh M; Jeppsson F; Juréus A; Neelissen J; Johnström P; Schou M; Svensson S
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2012;895-896:116-122

Rapid and sensitive measurement of PET radioligands in plasma by fast liquid chromatography/radiometric detection.

Nakao R; Schou M; Halldin C
Article: ANALYTICAL CHEMISTRY. 2012;84(7):3222-3230

Direct plasma metabolite analysis of positron emission tomography radioligands by micellar liquid chromatography with radiometric detection.

Nakao R; Schou M; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(3):415-424

Clinical validation of 18F-AZD4694, an amyloid-β-specific PET radioligand.

Cselényi Z; Jönhagen ME; Forsberg A; Halldin C; Julin P; Schou M; Johnström P; Varnäs K; Svensson S; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2011;54(14):847-854

Synthesis of a delta opioid agonist in [2H6], [2H4], [11C], and [14C] labeled forms

Elmore CS; Brush K; Schou M; Palmer W; Dorff PN; Powell ME; Hoesch V; Hall JE; Hudzik T; Halldin C; Dantzman CL
Article: SYNAPSE. 2009;63(10):871-880

In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand.

Varrone A; Steiger C; Schou M; Takano A; Finnema SJ; Guilloteau D; Gulyás B; Halldin C
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2009;19(16):4843-4845

Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter.

Schou M; Steiger C; Varrone A; Guilloteau D; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2009;52(5-6):158-165

A two-step one-pot radiosynthesis of the potent dopamine D₂/D₃ agonist PET radioligand [¹¹C]MNPA

Steiger C; Finnema SJ; Raus L; Schou M; Nakao R; Suzuki K; Pike VW; Wikstrom HV; Halldin C
Article: MOLECULAR IMAGING AND BIOLOGY. 2009;11(1):23-30

Investigation of the metabolites of (S,S)-[(11)C]MeNER in humans, monkeys and rats.

Schou M; Zoghbi SS; Shetty HU; Shchukin E; Liow J-S; Hong J; Andrée BA; Gulyás B; Farde L; Innis RB; Pike VW; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2008;51(3-4):146-152

Radiolabeling of a high potency cannabinoid subtype-1 receptor ligand, N-(4-fluoro-benzyl)-4-(3-(piperidin-1-yl)-indole-1-sulfonyl)benzamide (PipISB), with carbon-11 or fluorine-18

Donohue SR; Halldin C; Schou M; Hong J; Phebus L; Chernet E; Hitchcock SA; Gardinier KM; Ruley KM; Krushinski JH; Schaus J; Pike VW
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35(3):630-636

Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: a human whole-body PET study.

Takano A; Halldin C; Varrone A; Karlsson P; Sjöholm N; Stubbs JB; Schou M; Airaksinen AJ; Tauscher J; Gulyás B
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35(1):153-157

Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S,S)-[18F]FMeNER-D2.

Takano A; Gulyás B; Varrone A; Karlsson P; Schou M; Airaksinen AJ; Vandenhende F; Tauscher J; Halldin C
Article: APPLIED RADIATION AND ISOTOPES. 2007;65(3):293-300

Synthesis of 3H-labeled N-(3-iodoprop-2E-enyl)-2beta-carbomethoxy-3beta-(4-methylphenyl)nortropane (PE2I) and its interaction with mice striatal membrane fragments.

Stepanov V; Schou M; Järv J; Halldin C
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2007;15(2):616-625

Synthesis of 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET.

Schou M; Pike VW; Sóvágó J; Gulyás B; Gallagher PT; Dobson DR; Walter MW; Rudyk H; Farde L; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2006;49(11):1007-1019

Synthesis and PET evaluation of (R)-[S-methyl-¹¹C]thionisoxetine, a candidate radioligand for imaging brain norepinephrine transporters

Schou M; Pike VW; Varrone A; Gulyas B; Farde L; Halldin C
Article: PSYCHOPHARMACOLOGY. 2006;188(1):119-127

Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2.

Seneca N; Gulyás B; Varrone A; Schou M; Airaksinen A; Tauscher J; Vandenhende F; Kielbasa W; Farde L; Innis RB; Halldin C
Article: MOLECULAR IMAGING AND BIOLOGY. 2006;8(1):1-8

Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram.

Schou M; Sóvágó J; Pike VW; Gulyás B; Bøgesø KP; Farde L; Halldin C
Article: BRAIN RESEARCH BULLETIN. 2005;67(3):219-224

Lack of effect of reserpine-induced dopamine depletion on the binding of the dopamine-D3 selective radioligand, [11C]RGH-1756.

Sóvágó J; Farde L; Halldin C; Schukin E; Schou M; Laszlovszky I; Kiss B; Gulyás B
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15(5):517-520

Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2.

Schou M; Halldin C; Pike VW; Mozley PD; Dobson D; Innis RB; Farde L; Hall H
Article: NUCLEAR MEDICINE COMMUNICATIONS. 2005;26(8):695-700

Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates.

Seneca N; Andree B; Sjoholm N; Schou M; Pauli S; Mozley PD; Stubbs JB; Liow J-S; Sovago J; Gulyás B; Innis R; Halldin C
Article: SYNAPSE. 2005;56(2):100-104

Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters.

Ghose S; Fujita M; Morrison P; Uhl G; Murphy DL; Mozley PD; Schou M; Halldin C; Innis R
Article: JOURNAL OF ORGANIC CHEMISTRY. 2004;69(25):8694-8701

A total synthesis of hydroxylysine in protected form and investigations of the reductive opening of p-methoxybenzylidene acetals.

Gustafsson T; Schou M; Almqvist F; Kihlberg J
Article: SYNAPSE. 2004;53(2):57-67

PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain.

Schou M; Halldin C; Sóvágó J; Pike VW; Hall H; Gulyás B; Mozley PD; Dobson D; Shchukin E; Innis RB; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2003;30(7):707-714

Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER.

Schou M; Halldin C; Sóvágó J; Pike VW; Gulyás B; Mozley PD; Johnson DP; Hall H; Innis RB; Farde L
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All other publications

Review: TRAC-TRENDS IN ANALYTICAL CHEMISTRY. 2019;110:1-7

Sample preparation techniques for radiometabolite analysis of positron emission tomography radioligands; trends, progress, limitations and future prospects

Moein MM; Nakao R; Amini N; Abdel-Rehim M; Schou M; Halldin C
Review: CLINICAL AND TRANSLATIONAL IMAGING. 2017;5(3):291-298

PET microdosing of CNS drugs

Schou M; Varnas K
Review: CLINICAL AND TRANSLATIONAL IMAGING. 2017;5(3):275-289

New methodologies for the preparation of carbon-11 labeled radiopharmaceuticals.

Dahl K; Halldin C; Schou M
Review: CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2007;7(18):1806-1816

Development of radioligands for imaging of brain norepinephrine transporters in vivo with positron emission tomography.

Schou M; Pike VW; Halldin C

Employments

Adjunct Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2022-2026

Degrees and Education

Docent, Karolinska Institutet, 2020
Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2006

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