Mikael Karlsson

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About me

Mikael Karlsson, Professor of Immunology at the Department of Microbiology, Tumor and Cell Biology, researches the regulation of the immune system and why it sometimes becomes disrupted, leading to disease. He is particularly interested in B cells and macrophages. His research adds to knowledge of autoimmune diseases and is also related to cancer.

Articles

Article: BLOOD ADVANCES. 2024;:bloodadvances.2024012706

In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function.

Estupiñan Velasquez HY; Bouderlique T; He C; Berglöf A; Cappelleri A; Frengen N; Zain R; Karlsson MCI; Månsson R; Smith CIE
Article: ELIFE. 2023;12:e86454

The role of B cells in immune cell activation in polycystic ovary syndrome.

Ascani A; Torstensson S; Risal S; Lu H; Eriksson G; Li C; Teschl S; Menezes J; Sandor K; Ohlsson C; Svensson CI; Karlsson MCI; Stradner MH; Obermayer-Pietsch B; Stener-Victorin E
Article: CANCER RESEARCH. 2023;83(10):1628-1645

FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner.

He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernández-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Björnstedt M; Löhr MJ; Karlsson MCI; Heuchel R; Sarhan D
Article: CANCER IMMUNOLOGY RESEARCH. 2023;11(2):217-227

Antigen-Loaded Extracellular Vesicles Induce Responsiveness to Anti-PD-1 and Anti-PD-L1 Treatment in a Checkpoint Refractory Melanoma Model.

Veerman RE; Akpinar GG; Offens A; Steiner L; Larssen P; Lundqvist A; Karlsson MCI; Gabrielsson S
Article: ISCIENCE. 2022;25(11):105317

Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer.

Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Önfelt B; Schlisio S; Ravetch JV; Heuchel R; Löhr MJ; Karlsson MCI
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088

The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy.

Ingelshed K; Spiegelberg D; Kannan P; Påvénius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
Article: SCIENTIFIC REPORTS. 2022;12(1):12931

Deficiency of mature B cells does not alter the atherogenic response to castration in male mice.

Wilhelmson AS; Johansson I; Fogelstrand L; Fagman JB; Arnal J-F; Karlsson MCI; Tivesten Å
Article: AUTOPHAGY. 2022;18(1):204-222

LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.

Nabar NR; Heijjer CN; Shi C-S; Hwang I-Y; Ganesan S; Karlsson MCI; Kehrl JH
Article: AUTOPHAGY. 2021;17(11):3577-3591

CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response.

He C; Wang S; Zhou C; He M; Wang J; Ladds M; Lianoudaki D; Sedimbi SK; Lane DP; Westerberg LS; Li S; Karlsson MCI
Article: NATURE COMMUNICATIONS. 2021;12(1):4127

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma.

van Hooren L; Vaccaro A; Ramachandran M; Vazaios K; Libard S; van de Walle T; Georganaki M; Huang H; Pietilä I; Lau J; Ulvmar MH; Karlsson MCI; Zetterling M; Mangsbo SM; Jakola AS; Olsson Bontell T; Smits A; Essand M; Dimberg A
Article: CANCER RESEARCH. 2021;81(4):956-967

Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.

La Fleur L; Botling J; He F; Pelicano C; Zhou C; He C; Palano G; Mezheyeuski A; Micke P; Ravetch JV; Karlsson MCI; Sarhan D
Article: IMMUNITY. 2021;54(2):259-275.e7

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity.

Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaëlsson J; Smed-Sörensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
Article: MOLECULAR IMMUNOLOGY. 2021;130:49-54

Reading the room: iNKT cells influence B cell responses.

Leadbetter EA; Karlsson MCI
Article: JOURNAL OF AUTOIMMUNITY. 2021;117:102582

The B cell response to both protein and nucleic acid antigens displayed on apoptotic cells are dependent on endosomal pattern recognition receptors.

Garimella MG; He C; Chen G; Li Q-Z; Huang X; Karlsson MCI
Article: IMMUNOLOGY AND CELL BIOLOGY. 2021;99(2):234-243

GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens.

Rohrbeck L; Adori M; Wang S; He C; Tibbitt CA; Chernyshev M; Sirel M; Ribacke U; Murrell B; Bohlooly-Y M; Karlsson MC; Karlsson Hedestam GB; Coquet JM
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:642173

SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development.

Gao Y; Liu R; He C; Basile J; Vesterlund M; Wahren-Herlenius M; Espinoza A; Hokka-Zakrisson C; Zadjali F; Yoshimura A; Karlsson M; Carow B; Rottenberg ME
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016

Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells.

Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjärvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikström SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: BLOOD ADVANCES. 2020;4(16):3971-3976

Platelets mediate serological memory to neutralize viruses in vitro and in vivo.

Schrottmaier WC; Salzmann M; Badrnya S; Mussbacher M; Kral-Pointner JB; Morava S; Pirabe A; Brunnthaler L; Yaiw KC; Heber UM; Pereyra D; Andersen JT; Bergthaler A; Söderberg-Nauclér C; Karlsson MCI; Assinger A; Forsell MNE
Article: BLOOD ADVANCES. 2020;4(11):2439-2450

Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects.

Estupiñán HY; Bouderlique T; He C; Berglöf A; Gupta D; Saher O; Daza Cruz MÁ; Peña-Perez L; Yu L; Zain R; Karlsson MCI; Månsson R; Smith CIE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(16):9054-9063

Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses.

Sedimbi SK; Hägglöf T; Garimella MG; Wang S; Duhlin A; Coelho A; Ingelshed K; Mondoc E; Malin SG; Holmdahl R; Lane DP; Leadbetter EA; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2019;203(4):825-834

Allogenicity Boosts Extracellular Vesicle-Induced Antigen-Specific Immunity and Mediates Tumor Protection and Long-Term Memory In Vivo.

Larssen P; Veerman RE; Akpinar GG; Hiltbrunner S; Karlsson MCI; Gabrielsson S
Article: NATURE COMMUNICATIONS. 2019;10(1):2870

Actomyosin-driven force patterning controls endocytosis at the immune synapse.

Kumari A; Pineau J; Sáez PJ; Maurin M; Lankar D; San Roman M; Hennig K; Boura VF; Voituriez R; Karlsson MCI; Balland M; Lennon Dumenil A-M; Pierobon P
Article: JOURNAL OF IMMUNOLOGY. 2019;202(5):1510-1520

Gαi2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination.

Vural A; Nabar NR; Hwang I-Y; Sohn S; Park C; Karlsson MCI; Blumer JB; Kehrl JH
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(3):443-453

Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses.

Tripathi P; Sedimbi SK; Singh AK; Löfbom L; Issazadeh-Navikas S; Weiss S; Förster I; Karlsson MCI; Yrlid U; Kadri N; Cardell SL
Article: EMBO JOURNAL. 2019;38(2):e100010-19

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.

Bönelt P; Wöhner M; Minnich M; Tagoh H; Fischer M; Jaritz M; Kavirayani A; Garimella M; Karlsson MC; Busslinger M
Article: CIRCULATION. 2018;138(22):2513-2526

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.

Gisterå A; Klement ML; Polyzos KA; Mailer RKW; Duhlin A; Karlsson MCI; Ketelhuth DFJ; Hansson GK
Article: INTERNATIONAL JOURNAL OF CANCER. 2018;143(7):1741-1752

Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer.

La Fleur L; Boura VF; Alexeyenko A; Berglund A; Pontén V; Mattsson JSM; Djureinovic D; Persson J; Brunnström H; Isaksson J; Brandén E; Koyi H; Micke P; Karlsson MCI; Botling J
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):e145-e158

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.

Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gisterå A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(7):1519-1527

Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial Cells-Brief Report.

Wilhelmson AS; Lantero Rodriguez M; Svedlund Eriksson E; Johansson I; Fogelstrand P; Stubelius A; Lindgren S; Fagman JB; Hansson GK; Carlsten H; Karlsson MCI; Ekwall O; Tivesten Å
Article: NATURE COMMUNICATIONS. 2018;9(1):2067

Testosterone is an endogenous regulator of BAFF and splenic B cell number.

Wilhelmson AS; Lantero Rodriguez M; Stubelius A; Fogelstrand P; Johansson I; Buechler MB; Lianoglou S; Kapoor VN; Johansson ME; Fagman JB; Duhlin A; Tripathi P; Camponeschi A; Porse BT; Rolink AG; Nissbrandt H; Turley SJ; Carlsten H; Mårtensson I-L; Karlsson MCI; Tivesten Å
Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818

A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.

Chen X; Gustafsson S; Whitington T; Borné Y; Lorentzen E; Sun J; Almgren P; Su J; Karlsson R; Song J; Lu Y; Zhan Y; Hägg S; Svensson P; Smedby KE; Slager SL; Ingelsson E; Lindgren CM; Morris AP; Melander O; Karlsson T; de Faire U; Caidahl K; Engström G; Lind L; Karlsson MCI; Pedersen NL; Frostegård J; Magnusson PKE
Article: JOURNAL OF IMMUNOLOGY. 2018;200(2):775-787

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

Ádori M; Pedersen GK; Ádori C; Erikson E; Khoenkhoen S; Stark JM; Choi JH; Dosenovic P; Karlsson MCI; Beutler B; Karlsson Hedestam GB
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3033

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.

Lloyd KA; Wigerblad G; Sahlström P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stålesen R; Ossipova E; Lundqvist C; Ekwall O; Rönnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmström V; Grönwall C
Article: JOURNAL OF INFECTIOUS DISEASES. 2017;216(10):1308-1317

A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.

Svedin E; Utorova R; Hühn MH; Larsson PG; Stone VM; Garimella M; Lind K; Hägglöf T; Pincikova T; Laitinen OH; McInerney GM; Scholte B; Hjelte L; Karlsson MCI; Flodström-Tullberg M
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2017;15(1):152

The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype.

Lundgren S; Karnevi E; Elebro J; Nodin B; Karlsson MCI; Eberhard J; Leandersson K; Jirström K
Article: MOLECULAR ONCOLOGY. 2017;11(7):781-791

Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system.

Karlsson MC; Gonzalez SF; Welin J; Fuxe J
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196

PPAR-γ promotes type 2 immune responses in allergy and nematode infection.

Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Karlsson Hedestam GB; Hendriks RW; Chambers BJ; Nylén S; Coquet JM
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:738

Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback.

Forsell MNE; Kvastad L; Sedimbi SK; Andersson J; Karlsson MCI
Article: NATURE IMMUNOLOGY. 2016;17(12):1407-1414

Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.

Hägglöf T; Sedimbi SK; Yates JL; Parsa R; Salas BH; Harris RA; Leadbetter EA; Karlsson MCI
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(4):781-789

Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.

Smith LE; Olszewski MA; Georgoudaki A-M; Wagner AK; Hägglöf T; Karlsson MCI; Dominguez-Villar M; Garcia-Cozar F; Mueller S; Ravens I; Bernhardt G; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2618-2626

Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development.

Duhlin A; Chen Y; Wermeling F; Sedimbi SK; Lindh E; Shinde R; Halaby MJ; Kaiser Y; Winqvist O; McGaha TL; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2063-2068

Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.

Prokopec KE; Georgoudaki A-M; Sohn S; Wermeling F; Grönlund H; Lindh E; Carroll MC; Karlsson MCI
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2016;213(8):1537-1553

BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis.

Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Ortlieb Guerreiro-Cacais A; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
Article: NATURE COMMUNICATIONS. 2016;7:12175

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.

Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Liedén A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylén S; Westerberg LS
Article: ONCOTARGET. 2016;7(25):38707-38717

Exosomal cancer immunotherapy is independent of MHC molecules on exosomes.

Hiltbrunner S; Larssen P; Eldh M; Martinez-Bravo M-J; Wagner AK; Karlsson MCI; Gabrielsson S
Article: CELL REPORTS. 2016;15(9):2000-2011

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.

Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Östling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
Article: ONCOGENE. 2016;35(6):748-760

TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.

Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sund M; Karlsson MCI; Fuxe J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(40):12474-12479

Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells.

Vomhof-DeKrey EE; Yates J; Hägglöf T; Lanthier P; Amiel E; Veerapen N; Besra GS; Karlsson MCI; Leadbetter EA
Article: JOURNAL OF AUTOIMMUNITY. 2015;62:81-92

Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies.

Dahlberg CIM; Torres M-L; Petersen SH; Baptista MAP; Keszei M; Volpi S; Grasset EK; Karlsson MCI; Walter JE; Snapper SB; Notarangelo LD; Westerberg LS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(16):E2030-E2038

Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response.

Grasset EK; Duhlin A; Agardh HE; Ovchinnikova O; Hägglöf T; Forsell MN; Paulsson-Berne G; Hansson GK; Ketelhuth DFJ; Karlsson MCI
Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2014;34(1):56-70

Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosis.

Siegmann N; Worbs D; Effinger F; Bormann T; Gebhardt M; Ulrich M; Wermeling F; Müller-Hermelink E; Biedermann T; Tighe M; Edwards MJ; Caldwell C; Leadbetter E; Karlsson MCI; Becker KA; Gulbins E; Döring G
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):44-51

Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization.

Forsell MNE; Soldemo M; Dosenovic P; Wyatt RT; Karlsson MCI; Karlsson Hedestam GB
Article: CANCER RESEARCH. 2013;73(13):3865-3876

Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes.

Gehrmann U; Hiltbrunner S; Georgoudaki A-M; Karlsson MC; Näslund TI; Gabrielsson S
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70

AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment.

Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Loré K; Winqvist O; Chambers BJ; Karlsson MCI
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:1-6

Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1.

Lindh E; Brännström J; Jones P; Wermeling F; Hässler S; Betterle C; Garty BZ; Stridsberg M; Herrmann B; Karlsson MCI; Winqvist O
Article: JOURNAL OF IMMUNOLOGY. 2013;190(6):2712-2719

Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity.

Näslund TI; Gehrmann U; Qazi KR; Karlsson MCI; Gabrielsson S
Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6018-6026

BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.

Dosenovic P; Soldemo M; Scholz JL; O'Dell S; Grasset EK; Pelletier N; Karlsson MCI; Mascola JR; Wyatt RT; Cancro MP; Karlsson Hedestam GB
Article: PARTICLE AND FIBRE TOXICOLOGY. 2012;9:16

Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii.

Swedin L; Arrighi R; Andersson-Willman B; Murray A; Chen Y; Karlsson MCI; Georén SK; Tkach AV; Shvedova AA; Fadeel B; Barragan A; Scheynius A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(10):3909-3914

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.

Ravishankar B; Liu H; Shinde R; Chandler P; Baban B; Tanaka M; Munn DH; Mellor AL; Karlsson MCI; McGaha TL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):E1399-E1407

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.

Enoksson SL; Grasset EK; Hägglöf T; Mattsson N; Kaiser Y; Gabrielsson S; McGaha TL; Scheynius A; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3641-3652

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

Mattsson J; Yrlid U; Stensson A; Schön K; Karlsson MCI; Ravetch JV; Lycke NY
Article: CELLULAR & MOLECULAR IMMUNOLOGY. 2011;8(4):296-304

Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis.

Carnrot C; Prokopec KE; Råsbo K; Karlsson MC; Kleinau S
Article: BLOOD. 2011;117(20):5403-5412

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.

McGaha TL; Chen Y; Ravishankar B; van Rooijen N; Karlsson MCI
Article: PLOS ONE. 2011;6(7):e22202

The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patients.

Chen Y; Lind Enoksson S; Johansson C; Karlsson MA; Lundeberg L; Nilsson G; Scheynius A; Karlsson MCI
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(5):943-952

Invariant NKT cells limit activation of autoreactive CD1d-positive B cells.

Wermeling F; Lind SM; Jordö ED; Cardell SL; Karlsson MCI
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460

A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses.

Chen Y; Wermeling F; Sundqvist J; Jonsson A-B; Tryggvason K; Pikkarainen T; Karlsson MCI
Article: JOURNAL OF AUTOIMMUNITY. 2010;34(1):66-72

AIRE deficiency leads to impaired iNKT cell development.

Lindh E; Rosmaraki E; Berg L; Brauner H; Karlsson MCI; Peltonen L; Höglund P; Winqvist O
Article: AUTOIMMUNITY REVIEWS. 2009;9(1):49-52

An anatomical view on macrophages in tolerance.

Wermeling F; Karlsson MCI; McGaha TL
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2009;39(8):2293-2301

IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema.

Lind SM; Kuylenstierna C; Moll M; D Jordö E; Winqvist O; Lundeberg L; Karlsson MA; T Linder M; Johansson C; Scheynius A; Sandberg JK; Karlsson MCI
Article: ALLERGY. 2009;64(6):919-926

Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice.

Thunberg S; Neimert-Andersson T; Cheng Q; Wermeling F; Bergström U; Swedin L; Dahlén S-E; Arnér E; Scheynius A; Karlsson MCI; Gafvelin G; van Hage M; Grönlund H
Article: BLOOD. 2009;113(12):2673-2683

Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism.

Qazi KR; Gehrmann U; Domange Jordö E; Karlsson MCI; Gabrielsson S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19571-19578

Identification of a receptor required for the anti-inflammatory activity of IVIG.

Anthony RM; Wermeling F; Karlsson MCI; Ravetch JV
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18466-18471

AIRE regulates T-cell-independent B-cell responses through BAFF.

Lindh E; Lind SM; Lindmark E; Hässler S; Perheentupa J; Peltonen L; Winqvist O; Karlsson MCI
Article: BLOOD. 2008;112(10):4139-4147

WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.

Westerberg LS; de la Fuente MA; Wermeling F; Ochs HD; Karlsson MCI; Snapper SB; Notarangelo LD
Article: JOURNAL OF IMMUNOLOGY. 2008;180(10):6604-6610

A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen.

Hjelm F; Karlsson MCI; Heyman B
Article: JOURNAL OF IMMUNOLOGY. 2008;180(8):5670-5679

FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice.

McGaha TL; Karlsson MCI; Ravetch JV
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(10):2259-2265

Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus.

Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JV; Tryggvason K; Karlsson MCI
Article: BLOOD. 2006;108(6):1941-1948

Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma.

Hässler S; Ramsey C; Karlsson MC; Larsson D; Herrmann B; Rozell B; Backheden M; Peltonen L; Kämpe O; Winqvist O
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2003;198(2):333-340

Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone.

Karlsson MCI; Guinamard R; Bolland S; Sankala M; Steinman RM; Ravetch JV
Article: CANCER RESEARCH. 2002;62(23):6891-6900

Disruption of cell-cell adhesion enhances antibody-dependent cellular cytotoxicity: implications for antibody-based therapeutics of cancer.

Green SK; Karlsson MCI; Ravetch JV; Kerbel RS
Article: JOURNAL OF IMMUNOLOGY. 2001;167(10):5558-5564

FcgammaRIIB in IgG-mediated suppression of antibody responses: different impact in vivo and in vitro.

Karlsson MC; Getahun A; Heyman B
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;53(4):381-385

IgE-mediated suppression of primary antibody responses in vivo.

Karlsson MC; Diaz de Ståhl T; Heyman B
Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):618-622

IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice.

Wernersson S; Karlsson MC; Dahlström J; Mattsson R; Verbeek JS; Heyman B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(5):2244-2249

Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice.

Karlsson MC; Wernersson S; Diaz de Ståhl T; Gustavsson S; Heyman B
Article: IMMUNOGENETICS. 1998;48(5):344-349

Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule.

Vestberg M; Brunsberg U; Bergsteinsdottir K; Karlsson M; Gustafsson K; Wedekind D; Hedrich H; Holmdahl R
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Letter: CELLULAR & MOLECULAR IMMUNOLOGY. 2024;21(1):91-94

Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress.

Pei S; Sjölund J; Pan Y; Pietras K; Karlsson MCI
Review: JOURNAL OF CLINICAL MEDICINE. 2023;12(19):6268

B Cell Tolerance and Targeted Therapies in SLE.

Parodis I; Long X; Karlsson MCI; Huang X
Editorial comment: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(3):702-705

IgE autoantibodies: An innate connection to adaptive immunity.

Huang X; Karlsson MCI
Review: IMMUNOLOGICAL REVIEWS. 2021;299(1):93-107

Invariant natural killer T cells balance B cell immunity.

Leadbetter EA; Karlsson MCI
Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):26-43

Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity.

McGaha TL; Karlsson MCI
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2013;70(24):4795-4808

IL-18 in inflammatory and autoimmune disease.

Sedimbi SK; Hägglöf T; Karlsson MCI
Review: SEMINARS IN CANCER BIOLOGY. 2012;22(5-6):455-461

TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammation.

Fuxe J; Karlsson MCI
Review: MOLECULAR IMMUNOLOGY. 2011;48(11):1307-1318

Scavenger receptors as regulators of natural antibody responses and B cell activation in autoimmunity.

Jordö ED; Wermeling F; Chen Y; Karlsson MCI
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S64

The Wiskott-Aldrich syndrome protein is essential for development and correct function of the marginal zone

Westerberg L; De La Fuente M; Wermeling F; Ochs H; Karlsson M; Notarangelo L; Snapper S
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;53(4):331-334

No evidence for a role of FcgammaRIIB in suppression of in vivo antibody responses to erythrocytes by passively administered IgG.

Heyman B; Dahlström J; Diaz De Ståhl T; Getahun A; Wernersson S; Karlsson MC

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Professor, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2016-

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Docent, Karolinska Institutet, 2009

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