Affiliated to research
I am working on the roles of SNAP-25 alternative splice variants in long-term activity-dependent synaptic plasticity. Understanding the neurochemical correlates of synaptic transmission is central towards the complete understanding of how complicated neuronal circuits in the brain encodes the higher cognitive functions. Changes in the strength of synaptic transmission is the leading hypothesized mechanism underlining learning and memories formation capability of the brain. A better understanding of this phenomenon can unravel important mechanisms and pathways which can possibly be exploited to treat the vast array of brain disorders in which higher cognitive functions of the brain are compromised.
For this purpose, we are making use of sophisticated gene-targeted mouse mutants, where only one isoform of SNAP-25 is expressed at a time, and we are using molecular biology, electrophysiology (patch-clamping in acute hippocampal slices) and advance imaging (two-photon laser scanning microscopy & confocal imaging) techniques to understand the roles of individual alternative splice variants of SNAP-25.
Master in Neurosciences: Universiteit Antwerpen, Belgium
Master in Pharmacy: University of Peshawar, Pakistan