Pierre Le Merre
Research specialist
I am interested to understand what cognition means in biological terms and how abstract cognitive variables are implemented by cortical networks such as the prefrontal cortex.
About me
I am currently a research specialist in the lab of Dr. Marie Carlén. My academic journey has been shaped by the guidance of exceptional scientists, and I am continually benefiting from their insights. During my PhD, I was fortunate to be trained to handle the electrophysiological tools in the lab of Pr. Paul Salin working side by side with Dr. Sylvain Crochet. I got the unique opportunity to collaborate with Pr. Carl Petersen in Lausanne with whom we designed a long-term project together with Sylvain Crochet to study goal-directed behavior in mice. We found out together a crucial role of the prefrontal cortex and the hippocampus in a simple sensory detection task. During my postdoc in Sweden, I explored the neuronal mechanisms underlying the computational sensory and abstract properties of the prefrontal cortex in the inspiring scientific environment fostered by Pr. Marie Carlén.
Research description
In the lab we study the mouse prefrontal cortex (PFC). At large, the PFC still lacks a conclusive definition, and the structure and function of this brain area across species remain unresolved. The PFC is implicated in perceptual, emotional, social, motivational, and numerous other brain processes and considered to enable flexible behavior. In following, disturbed PFC functioning has been connected to most, if not all, mental disorders, including drug addiction. Present-day preclinical researchers increasingly utilize mice (Mus musculus) as model animals. However, in parallel clinical transfer of pre-clinically identified therapeutics targeting mental disorder (and other brain disorders) is still at large failing. Lack of understanding of the structure and function of the brain hampers the understanding of which findings are transferable between species. Needless to say, deciphering of the structure and function of the PFC is of great importance.
To go after functional properties of the mouse PFC we use a combination of state-of-the-art techniques: viral tracing, high-density extracellular recordings (Neuropixels, silicon probes), optogenetics and high resolution behavioral tracking. With this methodology, we hope to unravel essential functional features of the mouse mPFC furthering our understanding of this mysterious brain region.
Teaching portfolio
Teaching Assistant, University of Lyon and École Normale Supérieure (64h per year).
Since 2021, I am a co-organizer of the Brain Circuit Course in KI together with Marie Carlén and Dinos Meletis.
Education
2017 (September) - 2023 (August), Post-doctoral researcher at Karolinska Institutet, lab of Marie Carlén(KI, Stockholm, Sweden).
2017 (January to June), Post-doctoral researcher at the École Polytechnique Fédérale de Lausanne in the lab of Carl Petersen (EPFL, Lausanne, Switzerland).
2012- 2016, PhD degree in Neurosciences : Thesis title: Cortical dynamics and sensory processing in the awake mouse - impact of the behavioral context. Thesis co-directed between the University of Lyon by Paul Salin (CRNL, Lyon, France) and the École Polytechnique Fédérale de Lausanne by Carl Petersen (EPFL, Lausanne, Switzerland) and Sylvain Crochet (EPFL, Lausanne, Switzerland).
2009-2012, Master’s degree of Biosciences (MSc) at the École Normale Supérieure of Lyon.
2009-2010, Agrégation des Sciences de la Vie, de la Terre et de l’Univers (french national teacher grade in Biology and Geology).
2007-2008, Bachelor’s degree in Fundamental Biology (BSc) at the Ecole Normale Supérieure of Lyon.
Academic honours, awards and prizes
2020 – StratNeuro Postdoc Grant
2019-2021 – NARSAD Young Investigator Award (2019)
2019, NVIDIA GPU Grant program.
2018-2019, Karolinska Institutet fonder
2015, Fellowship, International Mobility Fellowship Lyon-St Etienne (PALSE).