I am a PhD student within the research group of Prof. Klas Blomgren, studying the effects of radiotherapy on tumour microenvironment in paediatric brain tumours.
During my PhD studies, my research is mainly focused on two projects:
1. The effects of lithium on tumour progression in a mouse model of Group 3 medulloblastoma.
In the course of this project, I have created an in vivo model of Group 3 medulloblastoma through an orthotopic injection of medulloblastoma cells. I then used this model to study the effects of lithium and irradiation on tumour growth and analysed it through whole-brain immunostaining and volume imaging techniques.
2. Studies of inter- and intra- tumoural heterogeneity and tumour microenvironment in medulloblastoma.
In the course of this project, I analysed single-cell datasets from Swedish medulloblastoma patients, comprising all four medulloblastoma subtypes. The main goal of this study was to look into the individual genomic landscapes of these tumours and the interactions between the tumour cells and their microenvironment, to provide a more detailed characterisation of different medulloblastoma subtypes and try to identify potential therapeutic targets.
I have a Bachelor's Degree in Biological Sciences with Honours from Lancaster University, and a Master's Degree in Molecular Medicine from the Charité, Medical University of Berlin.