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PostDoc

Carolina Vogs

Postdoc

About me

I am a PostDoc in toxicology at the Institute for Environmental Medicine, Unit of Integrative Toxicology. My background is computational toxicology, specifically with the focus to link chemical uptake in the body to the development of toxicity.  

Research description

My research interests relate to the understanding and modelling of toxicokinetic and toxicodynamic processes of chemicals. Toxicokinetics explains “how a chemical gets into a body and what happens to it in the body”, while toxicodynamics describes “what the chemical does to the body”. For this purpose, I study the uptake, distribution, biotransformation and excretion of chemicals in an organism that cause the development of effects over time and for different concentrations. I am specifically interested in using the zebrafish embryo as alternative model to reduce or even replace animal testing in toxicology.

Peer-reviewed Publications

Vogs, C., Johanson, G, Näslund, M., Wulff, S., Sjödin, M., Hellstrandh, M., Lindberg, M., Wincent, E., (2019): Toxicokinetics of perfluorinated alkyl acids influences their toxic potency in the zebrafish embryo (Danio rerio). Environ. Sci. Technol.  53(7), 3898-3907.

Kühnert, A., Vogs, C., Serwert, B., Aulhorn, S., Altenburger, R., Hollert, H., Küster, E., Busch, W., (2017): Biotransformation in the zebrafish embryo –temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene. Environ Poll., 230, 1 - 11.

Klüver, N., Vogs, C., Altenburger, R., Escher, B., Scholz, S., (2016): Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test. Chemo, 50(14), 164 - 173.

Vogs, C., Altenburger, R., (2016): Time-dependent effects in algae for chemicals with different adverse outcome pathways: A novel approach. Environ. Sci. Technol., 50(14), 7770 - 7780.

Massei, R., Vogs, C., Renner, P., Altenburger, R, Scholz, S., (2015): Differential sensitivity in embryonic stages of the zebrafish (Danio rerio): the role of toxicokinetics for stage-specific susceptibility for azinphos-methyl lethal effects. Aquat. Toxicol., 166, 36 - 41.

Vogs, C., Kühnert, A., Hug, C., Küster, E., Altenburger, R., (2015): A toxicokinetic study of specifically acting and reactive organic chemicals for the prediction of internal effect concentrations in Scenedesmus vacuolatus. Environ. Toxicol. Chem., 32(5), 1161 – 1172.

Faust, M., Vogs, C., Rotter, S., Wöltjen, J., Höllrigl-Rosta, A., Altenburger, R., (2014): Comparative assessment of plant protection products: how many cases will regulatory authorities have to answer?, Env. Sci. Eur., 26(1): 11

Kühnert, A., Vogs, C., Altenburger, R., Küster, E., (2013): The internal concentration of organic substances in fish embryos – a toxicokinetic approach. Environ. Toxicol. Chem., 32 (8), 1819-27.

Liu, Z., Flury, M., Harsh, J.B., Mathison, J.B., Vogs, C., (2013): Colloid mobilization in an undisturbed sediment core under semiarid recharge rates. Water Resour. Res., 49 (8), 4985 – 4996.

Vogs, C., Bandow, N., Altenburger, R., (2013): Effect propagation in a toxicokinetic/ toxicodynamic model explains delayed effects on the growth of unicellular green algae Scenedesmus vacuolatus. Environ. Toxicol. Chem., 32 (5), 1161 – 1172.

Teaching portfolio

I am supervising master students in the physiologically based pharmacokinetic modelling course and zebrafish embryo laboratory course. I have further experiences as supervisor for bachelor and master students.

Education

PhD in Ecotoxicology, Helmholtz-Centre for Environmental Research/RWTH Aachen University

Diploma in Geoecology, Technical University of Braunschweig

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