Hugo Zeberg

Research description

We study gene flow from Neandertals and Densiovans into modern humans. In addition, we are interested in genetic variability and the functional consequences thereof, particularly for membrane-bound proteins such as receptors and ion channels.

 

Selection of recent publications

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity. Zhou S, Butler-Laporte G, Nakanishi T, Morrison DR, Afilalo J, Afilalo M, Laurent L, Pietzner M, Kerrison N, Zhao K, Brunet-Ratnasingham E, Henry D, Kimchi N, Afrasiabi Z, Rezk N, Bouab M, Petitjean L, Guzman C, Xue X, Tselios C, Vulesevic B, Adeleye O, Abdullah T, Almamlouk N, Chen Y, Chassé M, Durand M, Paterson C, Normark J, Frithiof R, Lipcsey M, Hultström M, Greenwood CMT, Zeberg H, Langenberg C, Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE, Richards JB Nat Med 2021 Feb;():

A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. Zeberg H, Pääbo S Proc Natl Acad Sci U S A 2021 03;118(9):

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Zeberg H, Pääbo S Nature 2020 11;587(7835):610-612

A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans. Zeberg H, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, et al Curr. Biol. 2020 Jul;():

The Neandertal Progesterone Receptor. Zeberg H, Kelso J, Pääbo S Mol. Biol. Evol. 2020 May;():

Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects. Zeberg H, Sahlholm K Nat Commun 2018 09;9(1):3577