Longlong Luo

Longlong Luo

Affiliated to Research
Visiting address: CMM, L8:02, Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Derm o Ven Sonkoly E, 171 77 Stockholm
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Research

  • *Research description*
    My main scientific focus is to explore the role of a class of non-coding
    RNAs, microRNAs (miRNAs) in psoriasis, to understand their roles in
    regulatory pathways underlying chronic skin inflammation and to explore their
    potential to become therapeutic targets and biomarkers for psoriasis.
    Psoriasis is a common chronic inflammatory skin disease, considered as a
    systemic inflammatory disease with significant comorbidities.
    Results from our lab strongly implicate miRNAs in the pathogenesis of
    psoriasis. We are currently investigating the function and therapeutic
    potential of miRNAs in psoriasis by
    (1) in vivo functional studies of psoriasis-associated miRNAs, (2) exploring
    psoriasis associated
    pathways including miRNAs/ protein-coding transcripts (3) exploring
    possibilities of miRNA modulation for topical and systemic treatment. MiRNA
    modulation may be a promising approach for the treatment of psoriasis, or
    other inflammatory diseases, since miRNA modulation can affect entire
    pathways rather than single molecules, and miRNA inhibitors have been shown
    to be well-tolerated in human studies.
    Another main goal for my research is the identification of long non-coding
    RNA (lncRNAs). We have recently identified deregulated lncRNAs in psoriasis
    keratinocytes, among others lincRNA(LINC00958) was one of the top upregulated
    lncRNA. We hypothesize that LINC00958 and other lncRNAs with altered levels
    in psoriasis keratinocytes could modulate the pathophysiological hallmarks of
    psoriasis including epidermal hyperplasia, immune cell infiltration or
    altered differentiation.

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