Marina Korotkova

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Article: ARTHRITIS RESEARCH & THERAPY. 2024;26(1):61

Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis.

Liu J; Idborg H; Korotkova M; Lend K; van Vollenhoven R; Lampa J; Rudin A; Nordström D; Gudbjornsson B; Gröndal G; Uhlig T; Hørslev-Petersen K; Lund Hetland M; Østergaard M; Nurmohamed M; Jakobsson P-J
Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335

High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance.

Zaghmi A; Aybay E; Jiang L; Shang M; Steinmetz-Späh J; Wermeling F; Kogner P; Korotkova M; Östling P; Jakobsson P-J; Seashore-Ludlow B; Larsson K
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(15):1981-1998

Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodelling after myocardial infarction in mice.

Zhang Y; Steinmetz-Späh J; Idborg H; Zhu L; Li H; Rao H; Chen Z; Guo Z; Hu L; Xu C; Chen H; Korotkova M; Jakobsson P-J; Wang M
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2023;167:106738

Microsomal prostaglandin E synthase-1 inhibition promotes shunting in arachidonic acid metabolism during inflammatory responses in vitro.

Liu J; Peng B; Steinmetz-Späh J; Idborg H; Korotkova M; Jakobsson P-J
Article: JOURNAL OF LIPID RESEARCH. 2022;63(12):100310

Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3.

Steinmetz-Späh J; Liu J; Singh R; Ekoff M; Boddul S; Tang X; Bergqvist F; Idborg H; Heitel P; Rönnberg E; Merk D; Wermeling F; Haeggström JZ; Nilsson G; Steinhilber D; Larsson K; Korotkova M; Jakobsson P-J
Article: SCIENTIFIC REPORTS. 2022;12(1):11876

Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis.

Hardt U; Carlberg K; Af Klint E; Sahlström P; Larsson L; van Vollenhoven A; Hernandez Machado S; Israelsson L; Amara K; Chemin K; Korotkova M; Karlsson Hedestam GB; Catrina AI; Teichmann SA; Ståhl PL; Malmström V
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(7):1433-1449

Effects of microsomal prostaglandin E synthase-1 inhibition on resistance artery tone in patients with end stage kidney disease.

Steinmetz-Späh J; Arefin S; Larsson K; Jahan J; Mudrovcic N; Wennberg L; Stenvinkel P; Korotkova M; Kublickiene K; Jakobsson P-J
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):129

Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium.

Vickovic S; Schapiro D; Carlberg K; Lötstedt B; Larsson L; Hildebrandt F; Korotkova M; Hensvold AH; Catrina AI; Sorger PK; Malmström V; Regev A; Ståhl PL
Article: CARDIOVASCULAR RESEARCH. 2020;116(12):1972-1980

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.

Kirkby NS; Raouf J; Ahmetaj-Shala B; Liu B; Mazi SI; Edin ML; Chambers MG; Korotkova M; Wang X; Wahli W; Zeldin DC; Nüsing R; Zhou Y; Jakobsson P-J; Mitchell JA
Article: FASEB JOURNAL. 2020;34(8):11101-11114

Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting.

Kock A; Bergqvist F; Steinmetz J; Elfman LHM; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P; Larsson K
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:585282

Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis.

Hegewald AB; Breitwieser K; Ottinger SM; Mobarrez F; Korotkova M; Rethi B; Jakobsson P-J; Catrina AI; Wähämaa H; Saul MJ
Article: SCIENTIFIC REPORTS. 2019;9(1):18975

Exploring inflammatory signatures in arthritic joint biopsies with Spatial Transcriptomics.

Carlberg K; Korotkova M; Larsson L; Catrina AI; Ståhl PL; Malmström V
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638

Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone.

Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J
Article: FASEB JOURNAL. 2019;33(6):6933-6947

miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.

Saul MJ; Baumann I; Bruno A; Emmerich AC; Wellstein J; Ottinger SM; Contursi A; Dovizio M; Donnini S; Tacconelli S; Raouf J; Idborg H; Stein S; Korotkova M; Savai R; Terzuoli E; Sala G; Seeger W; Jakobsson P-J; Patrignani P; Suess B; Steinhilber D
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:636

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.

Bergqvist F; Ossipova E; Idborg H; Raouf J; Checa A; Englund K; Englund P; Khoonsari PE; Kultima K; Wheelock CE; Larsson K; Korotkova M; Jakobsson P-J
Article: EBIOMEDICINE. 2018;32:84-92

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.

Kock A; Larsson K; Bergqvist F; Eissler N; Elfman LHM; Raouf J; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P
Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):83

Targeted lipidomics analysis identified altered serum lipid profiles in patients with polymyositis and dermatomyositis.

Raouf J; Idborg H; Englund P; Alexanderson H; Dastmalchi M; Jakobsson P-J; Lundberg IE; Korotkova M
Article: PLOS ONE. 2018;13(2):e0193210

Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen.

Revathikumar P; Estelius J; Karmakar U; Le Maître E; Korotkova M; Jakobsson P-J; Lampa J
Article: CLINICAL SCIENCE. 2016;130(24):2295-2303

Deletion of mPGES-1 affects platelet functions in mice.

Raouf J; Mobarrez F; Larsson K; Jakobsson P-J; Korotkova M
Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):256

Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism.

Revathikumar P; Bergqvist F; Gopalakrishnan S; Korotkova M; Jakobsson P-J; Lampa J; Le Maître E
Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(7):1738-1750

Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis.

Munters LA; Loell I; Ossipova E; Raouf J; Dastmalchi M; Lindroos E; Chen Y-W; Esbjörnsson M; Korotkova M; Alexanderson H; Nagaraju K; Crofford LJ; Jakobsson P-J; Lundberg IE
Article: ARTHRITIS RESEARCH & THERAPY. 2016;18(1):136

Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents.

Loell I; Raouf J; Chen Y-W; Shi R; Nennesmo I; Alexanderson H; Dastmalchi M; Nagaraju K; Korotkova M; Lundberg IE
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt B):155-162

Impaired vagus-mediated immunosuppression in microsomal prostaglandin E synthase-1 deficient mice.

Le Maître E; Revathikumar P; Idborg H; Raouf J; Korotkova M; Jakobsson P-J; Lampa J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(26):8070-8075

COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.

Larsson K; Kock A; Idborg H; Arsenian Henriksson M; Martinsson T; Johnsen JI; Korotkova M; Kogner P; Jakobsson P-J
Article: PLOS ONE. 2015;10(7):e0133669

Expression of Prostaglandin E2 Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients.

de Hair MJH; Leclerc P; Newsum EC; Maijer KI; van de Sande MGH; Ramwadhdoebe TH; van Schaardenburg D; van Baarsen LGM; Korotkova M; Gerlag DM; Tak P-P; Jakobsson P-J
Article: JOURNAL OF REHABILITATION MEDICINE. 2014;46(1):67-72

Elevated expression of prostaglandin E2 synthetic pathway in skeletal muscle of prior polio patients.

Melin E; Lindroos E; Lundberg IE; Borg K; Korotkova M
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;107:18-25

Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice.

Idborg H; Olsson P; Leclerc P; Raouf J; Jakobsson P-J; Korotkova M
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;107:26-34

Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation.

Leclerc P; Idborg H; Spahiu L; Larsson C; Nekhotiaeva N; Wannberg J; Stenberg P; Korotkova M; Jakobsson P-J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(5):350-360

IL-1β/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts.

Leclerc P; Wähämaa H; Idborg H; Jakobsson PJ; Harris HE; Korotkova M
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;102-103:1-12

Characterization of a new mPGES-1 inhibitor in rat models of inflammation.

Leclerc P; Pawelzik S-C; Idborg H; Spahiu L; Larsson C; Stenberg P; Korotkova M; Jakobsson P-J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(2):293-299

Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis.

Loell I; Alemo Munters L; Pandya J; Zong M; Alexanderson H; Fasth AE; Ståhl Hallengren C; Rådmark O; Lundberg IE; Jakobsson P-J; Korotkova M
Article: ARTHRITIS RESEARCH & THERAPY. 2013;15(6):R205

Synovial membrane immunohistology in early-untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate.

Revu S; Neregård P; af Klint E; Korotkova M; Catrina AI
Article: CIRCULATION. 2012;125(23):2904-2913

Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.

Degousee N; Simpson J; Fazel S; Scholich K; Angoulvant D; Angioni C; Schmidt H; Korotkova M; Stefanski E; Wang X-H; Lindsay TF; Ofek E; Pierre S; Butany J; Jakobsson P-J; Keating A; Li R-K; Nahrendorf M; Geisslinger G; Backx PH; Rubin BB
Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(3):R121

Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue.

Gheorghe KR; Sadique S; Leclerc P; Idborg H; Wobst I; Catrina AI; Jakobsson P-J; Korotkova M
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(8):908-914

Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis.

Korotkova M; Daha NA; Seddighzadeh M; Ding B; Catrina AI; Lindblad S; Huizinga TWJ; Toes REM; Alfredsson L; Klareskog L; Jakobsson P-J; Padyukov L
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;178(4):1676-1688

Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation.

Båge T; Kats A; Lopez BS; Morgan G; Nilsson G; Burt I; Korotkova M; Corbett L; Knox AJ; Pino L; Jakobsson P-J; Modéer T; Yucel-Lindberg T
Article: PLOS ONE. 2011;6(1):e16378

Prostaglandin E2 synthesizing enzymes in rheumatoid arthritis B cells and the effects of B cell depleting therapy on enzyme expression.

Gheorghe KR; Thurlings RM; Westman M; Boumans MJ; Malmström V; Trollmo C; Korotkova M; Jakobsson P-J; Tak P-P
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2010;18(7):821-826

Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis.

Seddighzadeh M; Korotkova M; Källberg H; Ding B; Daha N; Kurreeman FAS; Toes REM; Huizinga TW; Catrina AI; Alfredsson L; Klareskog L; Padyukov L
Article: NEUROSCIENCE LETTERS. 2010;470(1):10-12

Cyclooxygenase-1 mediates the immediate corticosterone response to peripheral immune challenge induced by lipopolysaccharide.

Elander L; Ruud J; Korotkova M; Jakobsson P-J; Blomqvist A
Article: FRONTIERS IN PHARMACOLOGY. 2010;1:146

Microsomal prostaglandin e synthase-1 in rheumatic diseases.

Korotkova M; Jakobsson P-J
Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(3):R83

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.

Gheorghe KR; Korotkova M; Catrina AI; Backman L; af Klint E; Claesson H-E; Rådmark O; Jakobsson P-J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(11):1596-1602

Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis.

Korotkova M; Helmers SB; Loell I; Alexanderson H; Grundtman C; Dorph C; Lundberg IE; Jakobsson P-J
Article: CIRCULATION. 2008;117(13):1701-1710

Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.

Degousee N; Fazel S; Angoulvant D; Stefanski E; Pawelzik S-C; Korotkova M; Arab S; Liu P; Lindsay TF; Zhuo S; Butany J; Li R-K; Audoly L; Schmidt R; Angioni C; Geisslinger G; Jakobsson P-J; Rubin BB
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3439-3447

Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway.

Korotkova M; Westman M; Gheorghe KR; af Klint E; Trollmo C; Ulfgren AK; Klareskog L; Jakobsson P-J
Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2005;96(6):453-464

Subchronic toxicity of baltic herring oil and its fractions in the rat (III) bone tissue composition and dimension, and ratio of n-6/n-3 fatty acids in serum phospholipids.

Stern N; Korotkova M; Strandvik B; Oxlund H; Oberg M; Håkansson H; Lind PM
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2005;288(3):R575-R579

Gender-related long-term effects in adult rats by perinatal dietary ratio of n-6/n-3 fatty acids.

Korotkova M; Gabrielsson BG; Holmäng A; Larsson B-M; Hanson LA; Strandvik B
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1686(3):248-254

Perinatal essential fatty acid deficiency influences body weight and bone parameters in adult male rats.

Korotkova M; Ohlsson C; Gabrielsson B; Hanson LA; Strandvik B
Article: BRITISH JOURNAL OF NUTRITION. 2004;92(4):643-648

Dietary n-6:n-3 fatty acid ratio in the perinatal period affects bone parameters in adult female rats.

Korotkova M; Ohlsson C; Hanson LA; Strandvik B
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2004;137(2):237-244

The ratio of n-6 to n-3 fatty acids in maternal diet influences the induction of neonatal immunological tolerance to ovalbumin.

Korotkova M; Telemo E; Yamashiro Y; Hanson LA; Strandvik B
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(6):1774-1780

Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium.

Westman M; Korotkova M; af Klint E; Stark A; Audoly LP; Klareskog L; Ulfgren A-K; Jakobsson P-J
Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2004;15(2):112-122

Modulation of neonatal immunological tolerance to ovalbumin by maternal essential fatty acid intake.

Korotkova M; Telemo E; Hanson LA; Strandvik B
Article: JOURNAL OF LIPID RESEARCH. 2002;43(10):1743-1749

Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet.

Korotkova M; Gabrielsson B; Lönn M; Hanson L-A; Strandvik B
Article: PEDIATRICS INTERNATIONAL. 2002;44(4):347-352

Breast-feeding, a complex support system for the offspring.

Hanson LA; Korotkova M; Håversen L; Mattsby-Baltzer I; Hahn-Zoric M; Silfverdal S-A; Strandvik B; Telemo E
Article: PEDIATRIC RESEARCH. 2002;52(1):78-84

Maternal dietary intake of essential fatty acids affects adipose tissue growth and leptin mRNA expression in suckling rat pups.

Korotkova M; Gabrielsson B; Hanson L-A; Strandvik B
Article: JOURNAL OF LIPID RESEARCH. 2001;42(3):359-365

Maternal essential fatty acid deficiency depresses serum leptin levels in suckling rat pups.

Korotkova M; Gabrielsson B; Hanson LA; Strandvik B
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2000;1487(2-3):319-325

Essential fatty acid deficiency affects the fatty acid composition of the rat small intestinal and colonic mucosa differently.

Korotkova M; Strandvik B
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1999;1420(1-2):86-94

Composition and permeability of syncytiotrophoblast plasma membranes in pregnancies complicated by intrauterine growth restriction.

Powell TL; Jansson T; Illsley NP; Wennergren M; Korotkova M; Strandvik B
Journal article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 1998;26(5):592

ESSENTIAL FATTY ACID DEFICIENCY DIFFERENTLY AFFECTS THE FATTY ACID COMPOSITION OF THE RAT INTESTINAL AND COLONIC MUCOSA.

Korotkova M; A. D-H; Hanson LÅ; Strandvik B
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Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(5):745-763

Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis.

Jakobsson P-J; Robertson L; Welzel J; Zhang M; Zhihua Y; Kaixin G; Runyue H; Zehuai W; Korotkova M; Göransson U
Review: NATURE REVIEWS RHEUMATOLOGY. 2014;10(5):295-303

The skeletal muscle arachidonic acid cascade in health and inflammatory disease.

Korotkova M; Lundberg IE
Review: NATURE REVIEWS RHEUMATOLOGY. 2014;10(4):229-241

Persisting eicosanoid pathways in rheumatic diseases.

Korotkova M; Jakobsson P-J
Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2014;114(1):64-69

Characterization of microsomal prostaglandin E synthase 1 inhibitors.

Korotkova M; Jakobsson P-J
Review: NESTLE NUTRITION WORKSHOP SERIES: PEDIATRIC PROGRAM. 2006;57:223-233

Perinatal PUFA intake affects leptin and oral tolerance in neonatal rats and possibly immunoreactivity in intrauterine growth retardation in man.

Hanson LA; Korotkova M; Hahn-Zoric M; Zaman S; Malik A; Ashraf R; Amu S; Padyukov L; Telemo E; Strandvik B
Published conference paper: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 2003;90(6 Suppl 3):59-63

Breast-feeding, infant formulas, and the immune system.

Hanson LA; Korotkova M; Telemo E
Published conference paper: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 2003;90(6 Suppl 3):28-33

Antigen presentation and processing in the intestinal mucosa and lymphocyte homing.

Telemo E; Korotkova M; Hanson LA
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;987:199-206

The transfer of immunity from mother to child.

Hanson LA; Korotkova M; Lundin S; Håversen L; Silfverdal S-A; Mattsby-Baltzer I; Strandvik B; Telemo E
Review: SEMINARS IN FETAL & NEONATAL MEDICINE. 2002;7(4):275-281

The role of breastfeeding in prevention of neonatal infection.

Hanson LA; Korotkova M
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2002;503:99-106

Immune system modulation by human milk.

Hanson LA; Silfverdal S-A; Korotkova M; Erling V; Strömbeck L; Olcén P; Ulanova M; Hahn-Zoric M; Zaman S; Ashraf R; Telemo E

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