Pablo Marti Andrés

Pablo Marti Andrés

Postdoctoral Researcher
Visiting address: Solnavägen 9, 9A, 17177 Stockholm
Postal address: C2 Medicinsk biokemi och biofysik, C2 Biokemi Arnér, 171 77 Stockholm
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About me

  • My name is Pablo, and as a cancer researcher, I'm dedicated to studying the
    intricacies of diseases to discover novel approaches to individualized
    medicine, enhancing healthcare outcomes. I have a Ph.D. in Physiology and a
    background in pharmacology, and I focus on the redox biology side of cancer
    development and progression.
    One of my main ongoing projects aims at determining how changing trace
    element levels in cancer patients relate to modifications in signaling
    patterns that could promote chemotherapeutic resistance or potentiate their
    effect. By understanding this connection, I aim to contribute to the creation
    of more potent and effective anticancer drugs.
    I have a wide range of interests outside the lab. I love being outdoors,
    going on hikes, and discovering new places. I also like engaging with the
    arts through reading, theater, and music, and I enjoy traveling and immersing
    myself in other cultures as well. All of these experiences give my work a
    distinctive perspective and inspire me to make a difference in the world.
    I'm honored to be a member of the Karolinska Institutet family, and I'm
    dedicated to expanding our knowledge of cancer development and progression in
    order to offer patients the best healthcare possible and improve their
    outcomes everywhere.
    I obtained my Degree in Pharmacy from the University of Valencia in 2015. I
    then pursued a Master's Degree in Clinical Pharmacology at the same
    institution and obtained my degree in 2016. However, my desire to pursue more
    advanced research led me to enroll in an International Ph.D. in Physiology
    program, which I completed in 2020. During my Ph.D. studies, I conducted
    research in the groups of Dr. Sastre –at the University of Valencia– and
    Dr. Arnér –at Karolinska Institutet–, focusing on the role of TRP14 in
    protein cysteinylation, redox signaling, and inflammation in a mouse model of
    acute pancreatitis. My dedication and diligence during my PhD studies were
    recognized with the highest honor, Cum Laude, for my thesis.
    Throughout my academic journey, I have been fortunate enough to present my
    research at several international conferences throughout my academic career,
    enabling me to gain invaluable feedback and establish enduring partnerships
    with leading experts in my field. Today, I leverage my educational background
    and research experience as a strong foundation for my work.

Research

  • The complexity of cancer and how the environment in which it arises may have
    such a big impact on its development intrigue me. That is why my research is
    centered on investigating the role of trace elements in cancer pathogenesis.
    More specifically, I'm interested in how differences in selenium, copper, and
    zinc levels affect different redox signaling pathways in cancer cells.
    It is widely known that there are remarkable shifts in homeostasis,
    steady-state levels, and dynamics of trace elements in patients diagnosed
    with cancer. Unlike copper (Cu), which is usually increased, the levels of
    zinc (Zn) and selenium (Se) are often lower in the serum of cancer patients.
    In colorectal and breast cancers, elevated serum Cu correlates with the stage
    of the disease and its progression. In addition, tumor tissue appears to
    specifically accumulate Cu and Se, and in some tumor types, also Zn. The
    underlying molecular mechanisms explaining these effects are however
    essentially unknown and they are the focus of my main research project.
    The battle against cancer is ongoing, and as a researcher, I am dedicated to
    doing my part to develop innovative therapies. My work centers on
    understanding the complex interactions between trace elements and cancer,
    with a particular focus on how these elements modulate redox signaling
    pathways. Through my research, I aim to identify new therapeutic targets and
    contribute to the development of more effective and personalized cancer
    treatments.
    Additionally, I'm still working on the thioredoxin-related protein of 14 kDa
    (TRP14), which I started doing throughout my Ph.D. studies. My research is
    shedding new light on the roles of this recently-discovered protein by
    investigating the modulation of cellular redox functions in the context of
    different diseases.

Teaching

  • As a dedicated teacher, I work hard to make learning fun and interesting for
    my students. I currently teach Biochemistry to Biomedical students and
    Medical students, primarily in laboratory sessions but sometimes in seminars
    and other projects. I'm committed to sharing my knowledge and experience with
    my students, and I constantly work to create a positive, welcoming
    environment in which everyone is encouraged to participate and voice their
    opinions.
    In addition to my classroom teaching, I also have extensive experience
    supervising students who come to the lab. I think that hands-on work is an
    essential component of learning, and I enjoy helping students in gaining the
    abilities and knowledge they will require to be successful in their future
    careers.
    As a general rule, I focus on making studying entertaining and fun while
    still making sure that students acquire the knowledge and abilities they need
    to thrive in their future careers. I am dedicated to keeping myself updated
    with the most recent research and teaching strategies, and I am constantly
    searching for fresh approaches to engage and motivate my students.

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