Patricia Muñoz

Publications
Public outreach and news

Articles

Journal article: NEUROTOXICITY RESEARCH. 2022;40(6):2135-2147

JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.

Santos CC; Cardim-Pires TR; Shvachiy L; Fonseca-Fonseca LA; Muñoz P; Almeida ÁMAN; Costa ACS; Teles-Souza J; Ochoa-Rodríguez E; de Fátima Dias Costa M; Palhano FL; Segura-Aguilar J; Barbosa DB; do Bomfim MR; Dos Santos Junior MC; Leite FHA; da Rocha Pita SS; Costa SL; Núñez-Figueredo Y; Outeiro TF; Foguel D; Silva VDA
Article: NEUROTOXICITY RESEARCH. 2021;39(2):182-190

Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes.

Valdes R; Armijo A; Muñoz P; Hultenby K; Hagg A; Inzunza J; Nalvarte I; Varshney M; Mannervik B; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2020;38(3):579-584

The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity.

Santos CC; Muñoz P; Almeida ÁMAN; de Lima David JP; David JM; Lima Costa S; Segura-Aguilar J; Silva VDA
Journal article: NEUROTOXICITY RESEARCH. 2019;35(1):255-259

DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells.

Meléndez C; Muñoz P; Segura-Aguilar J
Journal article: CLIN PHARMACOL TRANSL MED. 2019;3(1):125-133

Protective Effects of Crude Plant Extracts against Aminochrome-induced toxicity in Human Astrocytoma Cells: Implications for Parkinson's Disease.

Ngoungoure VLN; Muñoz P; Tizabi Y; Valdes R; Moundipa PF; Segura-Aguilar J
Journal article: ACS CHEMICAL NEUROSCIENCE. 2017;8(10):2247-2253

The Importance of Mitophagy in Maintaining Mitochondrial Function in U373MG Cells. Bafilomycin A1 Restores Aminochrome-Induced Mitochondrial Damage.

Huenchuguala S; Muñoz P; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2017;32(3):362-367

DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers.

Muñoz PS; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2017;32(2):172-174

On the Role of Mining Exposure in Epigenetic Effects in Parkinson's Disease.

Castillo S; Muñoz P; Behrens MI; Diaz-Grez F; Segura-Aguilar J
Journal article: PROGRESS IN NEUROBIOLOGY. 2017;155:96-119

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease.

Zucca FA; Segura-Aguilar J; Ferrari E; Muñoz P; Paris I; Sulzer D; Sarna T; Casella L; Zecca L
Journal article: NEUROTOXICITY RESEARCH. 2017;32(1):134-140

On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo.

Herrera-Soto A; Díaz-Veliz G; Mora S; Muñoz P; Henny P; Steinbusch HWM; Segura-Aguilar J
Journal article: ACS CHEMICAL NEUROSCIENCE. 2017;8(4):702-711

Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?

Herrera A; Muñoz P; Steinbusch HWM; Segura-Aguilar J
Journal article: ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS. 2017;89(1):247-261

Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite).

Silva VDA; Cuevas C; Muñoz P; Villa M; Ahumada-Castro U; Huenchuguala S; Santos CCD; Araujo FMDE; Ferreira RS; Silva VBDA; Silva JHCE; Soares ÉN; Velozo ES; Segura-Aguilar J; Costa SL
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2016;73(18):3583-3597

Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease.

Herrera A; Muñoz P; Paris I; Díaz-Veliz G; Mora S; Inzunza J; Hultenby K; Cardenas C; Jaña F; Raisman-Vozari R; Gysling K; Abarca J; Steinbusch HWM; Segura-Aguilar J
Journal article: NEUROTOXICOLOGY. 2016;55:10-12

DT-diaphorase protects astrocytes from aminochrome-induced toxicity.

Huenchuguala S; Muñoz P; Graumann R; Paris I; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2016;30(1):41-52

Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases.

Costa SL; Silva VDA; Dos Santos Souza C; Santos CC; Paris I; Muñoz P; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2016;29(3):381-393

Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin.

Briceño A; Muñoz P; Brito P; Huenchuguala S; Segura-Aguilar J; Paris IB
Journal article: FRONTIERS IN PHARMACOLOGY. 2016;7:179

Commentary: A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease.

Muñoz P; Segura-Aguilar J
Journal article: FRONTIERS IN NEUROSCIENCE. 2016;10:320

Corrigendum: Commentary: Evaluation of Models of Parkinson's Disease.

Muñoz P; Paris I; Segura-Aguilar J
Journal article: CURRENT MEDICINAL CHEMISTRY. 2016;23(4):346-359

Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease.

Segura-Aguilar J; Muñoz P; Paris I
Journal article: TOXICOLOGICAL SCIENCES. 2015;145(1):37-47

DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity.

Muñoz P; Cardenas S; Huenchuguala S; Briceño A; Couve E; Paris I; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2015;27(3):217-228

Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity.

Cuevas C; Huenchuguala S; Muñoz P; Villa M; Paris I; Mannervik B; Segura-Aguilar J
Journal article: JOURNAL OF NEUROCHEMISTRY. 2014;129(6):898-915

Protective and toxic roles of dopamine in Parkinson's disease.

Segura-Aguilar J; Paris I; Muñoz P; Ferrari E; Zecca L; Zucca FA
Article: AUTOPHAGY. 2014;10(4):618-630

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction.

Huenchuguala S; Muñoz P; Zavala P; Villa M; Cuevas C; Ahumada U; Graumann R; Nore BF; Couve E; Mannervik B; Paris I; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2013;24(1):94-101

One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity.

Villa M; Muñoz P; Ahumada-Castro U; Paris I; Jiménez A; Martínez I; Sevilla F; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2012;22(3):249

Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson's Disease (vol 22, pg 177, 2012)

Munoz P; Huenchuguala S; Paris I; Cuevas C; Villa M; Caviedes P; Segura-Aguilar J; Tizabi Y
Journal article: NEUROTOXICITY RESEARCH. 2012;22(2):177-180

Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease.

Muñoz P; Huenchuguala S; Paris I; Cuevas C; Villa M; Caviedes P; Segura-Aguilar J; Tizabi Y
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1822(7):1125-1136

Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity.

Muñoz P; Paris I; Sanders LH; Greenamyre JT; Segura-Aguilar J
Journal article: PARKINSONS DISEASE. 2012;2012:1-13

Dopamine oxidation and autophagy.

Muñoz P; Huenchuguala S; Paris I; Segura-Aguilar J
Journal article: TOXICOLOGICAL SCIENCES. 2011;121(2):376-388

Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line.

Paris I; Muñoz P; Huenchuguala S; Couve E; Sanders LH; Greenamyre JT; Caviedes P; Segura-Aguilar J
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2010;23(9):1492-1496

Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity.

Lozano J; Muñoz P; Nore BF; Ledoux S; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2010;18(1):82-92

Aminochrome induces disruption of actin, alpha-, and beta-tubulin cytoskeleton networks in substantia-nigra-derived cell line.

Paris I; Perez-Pastene C; Cardenas S; Iturriaga-Vasquez P; Muñoz P; Couve E; Caviedes P; Segura-Aguilar J
Journal article: NEUROTOXICITY RESEARCH. 2009;16(3):271-279

Molecular and neurochemical mechanisms in PD pathogenesis.

Paris I; Lozano J; Perez-Pastene C; Muñoz P; Segura-Aguilar J
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Review: NEURAL REGENERATION RESEARCH. 2022;17(9):1861-1866

Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity.

Segura-Aguilar J; Mannervik B; Inzunza J; Varshney M; Nalvarte I; Muñoz P
Review: ANTIOXIDANTS. 2022;11(2):296

Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase.

Segura-Aguilar J; Muñoz P; Inzunza J; Varshney M; Nalvarte I; Mannervik B

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