About me

I graduated with Master’s of Pharmacy degree from the Medical University of Warsaw, Poland. Next, I did my Ph.D. as a Marie Curie Fellow with Prof. Nicholas M. Barnes at the University of Birmingham and Celentyx Ltd., UK (immunological and neuropharmacological studies on therapeutical drugs and targets, including orphan G protein-coupled receptors, GPCRs).

I had my first post-doctoral stay in the lab of Prof. Agnieszka Chacinska at the IIMCB, Warsaw, Poland (protein biogenesis in synaptoneurosomes). In August 2022, I joined Prof. Gunnar Schulte's lab for my second post-doc (pharmacology of class F Frizzleds GPCRs).

In February 2022, I received Higher doctorate (Doctor of Science; D.Sc.) in medical sciences from the Medical University of Lublin, Poland. 

Research description

In my post-doctoral research in the Schulte lab, I have been focusing on exploring pharmacology of Frizzleds by employing structural-functional analysis. To this end, I like to merge my own ideas with conceptual and methodological approaches previously applied with success in other classes of GPCRs.

I am currently setting up my independent line of research on orphan GPCRs' role in health and disease.

Teaching portfolio

Pharmacokinetics and receptor pharmacology; seminar teacher (Den sjuka människan 2.1)

Project work; supervisor (Basvetenskap 1)

Advanced receptor pharmacology; course responsible (The Global Master's Programme in Translational Physiology and Pharmacology)

Completed a 14-week “Teaching and learning in higher education, distance” course (Grundläggande högskolepedagogik, distans), 12/2022


Master’s (Pharmacy), Medical University of Warsaw, Poland, 09/2007-02/2013

Ph.D. (Clinical and Experimental Medicine), University of Birmingham, UK, 09/2013-07/2017; Marie Curie Initial Training Programme DECIDE project no 315902

Higher doctorate/D.Sc. (Medical Sciences), Medical University of Lublin, Poland, 02/2022

Academic honours, awards and prizes

Molecular Pharmacology Highlighted Trainee Author, January 2020



Karolinska Institutet Research Foundation Grant 2022

Vetenskapsrådet starting grant 2022

BPS Pharmacology 2022 bursary

Stiftelsen Lars Hiertas Minne 2021

Karolinska Institutet Research Foundation Grant 2020

Stiftelsen Lars Hiertas Minne 2020

Cancerfonden Postdoctoral Position 2020

Svenska Sällskapet för Medicinsk Forskning Postdoctoral Grant 2020

Alex and Eva Wallström Foundation 2020

Stiftelsen Lars Hiertas Minne 2019

Karolinska Institutet Research Foundation Grant 2018

Karolinska Institutet Travel Grant 2018


Editorial board membership

BMC Pharmacology and Toxicology

FEBS Open Bio (Editorial Advisory Board)

Farmacja Polska 



30. Bowin CF, Kozielewicz P*, Grätz L*, Kowalski-Jahn M, Schihada H, Schulte G. WNT stimulation induces conformational dynamics of Frizzled-Dishevelled interaction. Science Signaling 2022 (accepted)

the previous version available on bioRxiv (doi: https://doi.org/10.1101/2022.07.19.500578)


29. Grätz L, Sajkowska-Kozielewicz JJ, Wesslowski J, Petzold K, Davidson G, Schulte G, Kozielewicz P. Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model. bioRxiv 2022; doi: https://doi.org/10.1101/2022.07.04.498383 (pre-print)


28. Kozielewicz P,  Schulte G. NanoBRET and NanoBiT/BRET-Based Ligand Binding Assays Permit Quantitative Assessment of Small Molecule Ligand Binding to Smoothened. Methods in molecular biology (Clifton, N.J.) 2022 2374; 195-204


27. Xu L*,  Chen B*,  Schihada H*,  Wright SC*,  Turku A,  Wu YR,  Han GW,  Kowalski-Jahn M,  Kozielewicz P,  Bowin CF,  Zhang XJ,  Li C,  Bouvier M,  Schulte G,  Xu F. Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G(s). CELL RESEARCH 2021 31;10

View in Web of Science

26. Schulte G, Kozielewicz P. (editors) Pharmacology of the WNT Signaling System. Handbook of experimental pharmacology 2021 


25. Kozielewicz P,  Schihada H,  Schulte G. Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation. Handbook of experimental pharmacology 2021 269; 101-115


24. Kozielewicz P #,  Shekhani R,  Moser S,  Bowin CF,  Wesslowski J,  Davidson G #,  Schulte G #. Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments. ACS pharmacology & translational science 2021 4;3 1235-1245


23. Turku A,  Schihada H*,  Kozielewicz P*,  Bowin CF,  Schulte G. Residue 6.43 defines receptor function in class F GPCRs. Nature communications 2021 12;1 3919-

View in Web of Science


22. Alexander SP,  Christopoulos A,  Davenport AP,  Kelly E,  Mathie A,  Peters JA,  Veale EL,  Armstrong JF,  Faccenda E,  Harding SD,  Pawson AJ,  Southan C,  Davies JA,  Abbracchio MP,  Alexander W,  Al-Hosaini K,  Bäck M,  Barnes NM,  Bathgate R,  Beaulieu JM,  Bernstein KE,  Bettler B,  Birdsall NJM,  Blaho V,  Boulay F,  Bousquet C,  Bräuner-Osborne H,  Burnstock G,  Caló G,  Castaño JP,  Catt KJ,  Ceruti S,  Chazot P,  Chiang N,  Chini B,  Chun J,  Cianciulli A,  Civelli O,  Clapp LH,  Couture R,  Csaba Z,  Dahlgren C,  Dent G,  Singh KD,  Douglas SD,  Dournaud P,  Eguchi S,  Escher E,  Filardo EJ,  Fong T,  Fumagalli M,  Gainetdinov RR,  Gasparo M,  Gerard C,  Gershengorn M,  Gobeil F,  Goodfriend TL,  Goudet C,  Gregory KJ,  Gundlach AL,  Hamann J,  Hanson J,  Hauger RL,  Hay DL,  Heinemann A,  Hollenberg MD,  Holliday ND,  Horiuchi M,  Hoyer D,  Hunyady L,  Husain A,  IJzerman AP,  Inagami T,  Jacobson KA,  Jensen RT,  Jockers R,  Jonnalagadda D,  Karnik S,  Kaupmann K,  Kemp J,  Kennedy C,  Kihara Y,  Kitazawa T,  Kozielewicz P,  Kreienkamp HJ,  Kukkonen JP,  Langenhan T,  Leach K,  Lecca D,  Lee JD,  Leeman SE,  Leprince J,  Li XX,  Williams TL,  Lolait SJ,  Lupp A,  Macrae R,  Maguire J,  Mazella J,  McArdle CA,  Melmed S,  Michel MC,  Miller LJ,  Mitolo V,  Mouillac B,  Müller CE,  Murphy P,  Nahon JL,  Ngo T,  Norel X,  Nyimanu D,  O'Carroll AM,  Offermanns S,  Panaro MA,  Parmentier M,  Pertwee RG,  Pin JP,  Prossnitz ER,  Quinn M,  Ramachandran R,  Ray M,  Reinscheid RK,  Rondard P,  Rovati GE,  Ruzza C,  Sanger GJ,  Schöneberg T,  Schulte G,  Schulz S,  Segaloff DL,  Serhan CN,  Stoddart LA,  Sugimoto Y,  Summers R,  Tan VP,  Thal D,  Thomas WW,  Timmermans PBMWM,  Tirupula K,  Tulipano G,  Unal H,  Unger T,  Valant C,  Vanderheyden P,  Vaudry D,  Vaudry H,  Vilardaga JP,  Walker CS,  Wang JM,  Ward DT,  Wester HJ,  Willars GB,  Woodruff TM,  Yao C,  Ye RD. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. British journal of pharmacology 2021 178 Suppl 1; S27-S156

View in Web of Science


21. Kozielewicz P,  Bowin CF,  Turku A,  Schulte G. A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine. Molecular pharmacology 2020 97;1 23-34

View in Web of Science


20. Wesslowski J*,  Kozielewicz P*,  Wang X,  Cui H,  Schihada H,  Kranz D,  Karuna M P,  Levkin P,  Gross JC,  Boutros M,  Schulte G,  Davidson G. eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled. The Journal of biological chemistry 2020 295;26 8759-8774

View in Web of Science


19. Sajkowska-Kozielewicz JJ,  Kozielewicz P,  Makarova K,  Stocki M,  Barnes NM,  Paradowska K. Geissospermiculatine, a New Alkaloid from Geissospermum reticulatum Bark. Molecules (Basel, Switzerland) 2020 26;1

View in Web of Science


18. Kuzniewska B,  Cysewski D,  Wasilewski M,  Sakowska P,  Milek J,  Kulinski TM,  Winiarski M,  Kozielewicz P,  Knapska E,  Dadlez M,  Chacinska A,  Dziembowski A,  Dziembowska M. Mitochondrial protein biogenesis in the synapse is supported by local translation. EMBO reports 2020 21;8 e48882-

View in Web of Science


17. Kozielewicz P,  Turku A,  Schulte G. Molecular Pharmacology of Class F Receptor Activation. Molecular pharmacology 2020 97;2 62-71

View in Web of Science


16. Schulte G,  Kozielewicz P. Structural insight into Class F receptors - What have we learnt regarding agonist-induced activation?. Basic & clinical pharmacology & toxicology 2020 126 Suppl 6; 17-24

View in Web of Science


15. Kozielewicz P,  Turku A,  Bowin CF,  Petersen J,  Valnohova J,  Cañizal MCA,  Ono Y,  Inoue A,  Hoffmann C,  Schulte G. Structural insight into small molecule action on Frizzleds. Nature communications 2020 11;1 414-

View in Web of Science


14. Wright SC*,  Kozielewicz P*,  Kowalski-Jahn M,  Petersen J,  Bowin CF,  Slodkowicz G,  Marti-Solano M,  Rodríguez D,  Hot B,  Okashah N,  Strakova K,  Valnohova J,  Babu MM,  Lambert NA,  Carlsson J,  Schulte G. A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection. Nature communications 2019 10;1 667-

View in Web of Science


13. Kozielewicz P. Comment on: Triazoles bind the C-terminal domain of SMO: Illustration by docking and molecular dynamics simulations the binding between SMO and triazoles. Life sciences 2019 225; 132-

View in Web of Science


12. Kozielewicz P #,  Grafton G,  Sajkowska-Kozielewicz JJ,  Barnes NM. Overexpression of Orphan Receptor GPR61 Increases cAMP Levels upon Forskolin Stimulation in HEK293 Cells: in vitro and in silico Validation of 5-(Nonyloxy)Tryptamine as a Low-Affinity Inverse Agonist. Pharmacology 2019 104;5-6 377-382

View in Web of Science


11. Alexander SPH,  Christopoulos A,  Davenport AP,  Kelly E,  Mathie A,  Peters JA,  Veale EL,  Armstrong JF,  Faccenda E,  Harding SD,  Pawson AJ,  Sharman JL,  Southan C,  Davies JA,  CGTP Collaborators. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors. British journal of pharmacology 2019 176 Suppl 1; S21-S141

View in Web of Science


10. Tzeli D,  Kozielewicz P,  Zloh M,  Antonow D,  Tsoungas PG,  Petsalakis ID. Naphthalene Peri Annelated N,N- and N,O-Heterocycles: The Effect of Heteroatom-Guided Peri-Fusion on Their Structure and Reactivity Profiles-A Theoretical Endoscopy. CHEMISTRYSELECT 2018 3;33 9743-9752

View in Web of Science


9. Tzeli D,  Tsoungas PG,  Petsalakis ID,  Kozielewicz P. Intramolecular single H bonding vs bifurcation in tuning the conformation of 2,2'-dihydroxybenzophenone and its derivatives: a DFT insight. STRUCTURAL CHEMISTRY 2017 28;4 925-943

View in Web of Science


8. Kozielewicz P #,  Alomar H,  Yusof S,  Grafton G,  Cooper AJ,  Curnow SJ,  Ironside JW,  Pall H,  Barnes NM. N-glycosylation and expression in human tissues of the orphan GPR61 receptor. FEBS open bio 2017 7;12 1982-1993

View in Web of Science


7. Tzeli D,  Kozielewicz P,  Zervou M,  Potamitis C,  Kokkotou K,  Rak B,  Petrou A,  Tsolaki E,  Gavalas A,  Geronikaki A,  Petsalakis ID,  Tsoungas PG. 2, 2 '-Dihydroxybenzophenones and Derivatives. Efficient Synthesis and Structure Endoscopy by DFT and NMR. Credentials as Potent Antiinflammatory Agents. CHEMISTRYSELECT 2016 1;10 2426-2438

View in Web of Science


6. Sajkowska-Kozielewicz JJ,  Kozielewicz P,  Barnes NM,  Wawer I,  Paradowska K. Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of Geissospermum reticulatum Bark. Oxidative medicine and cellular longevity 2016 2016; 2573580-

View in Web of Science


5. Kozielewicz P #,  Grafton G,  Kutner A,  Curnow SJ,  Gordon J,  Barnes NM. Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors. The Journal of steroid biochemistry and molecular biology 2016 164; 98-105

View in Web of Science


4. Tzeli D,  Tsoungas PG,  Petsalakis ID,  Kozielewicz P,  Zloh M. Intramolecular cyclization of beta-nitroso-o-quinone methides. A theoretical endoscopy of a potentially useful innate 'reclusive' reaction. TETRAHEDRON 2015 71;2 359-369

View in Web of Science


3. Kozielewicz P,  Tzeli D,  Tsoungas PG,  Zloh M. Arene-fused 1,2-oxazole N-oxides and derivatives. The impact of the N-O dipole and substitution on their aromatic character and reactivity profile. Can it be a useful structure in synthesis? A theoretical insight. STRUCTURAL CHEMISTRY 2014 25;6 1837-1846

View in Web of Science


2. Kozielewicz P,  Tsoungas PG,  Tzeli D,  Petsalakis ID,  Zloh M. beta-Nitroso-o-quinone methides: potent intermediates in organic chemistry and biology. The impact of the NO group on their structure and reactivity profile: a theoretical insight. STRUCTURAL CHEMISTRY 2014 25;6 1711-1723

View in Web of Science


1. Kozielewicz P #,  Paradowska K,  Eric S,  Wawer I,  Zloh M. Insights into mechanism of anticancer activity of pentacyclic oxindole alkaloids of Uncaria tomentosa by means of a computational reverse virtual screening and molecular docking approach. MONATSHEFTE FUR CHEMIE 2014 145;7 1201-1211

View in Web of Science


* - equal contribution

# - corresponding author