Ying Zhao

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About me

• Bachelor of Science in Pharmacy (2001), Peking University Health Science Center, P.R.China
• Master of Science in Pharmaceutics (2004), Peking University Health Science Center, P.R.China
• Ph.D. in Bioengineering (2009), National University of Singapore &
Institute of Bioengineering and Nanotechnology, Singapore
• Researcher at Prof Moustapha Hassan group, Experimental Cancer Medicine (ECM), Division of Biomolecular and Cellular Medicine (BCM), Department of Laboratory Medicine (LABMED).
• Core facility manager/scientific director at Preclinical Imaging Facility (PIF), Preclinical Laboratory (PKL), Karolinska University Hospital.

Articles

Journal article: BLOOD. 2023;142:1205

N-Acetylneuraminic Acid Induces Vascular Endothelial Dysfunction through Targeting Mcu/SQSTM1 Pathway and Attenuates Atherosclerosis

Ma L; Wang X; Xiang P; Chen Q; Zhao Y; Hassan M; Yu C
Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(20):e169671

Antioxidants stimulate BACH1-dependent tumor angiogenesis.

Wang T; Dong Y; Huang Z; Zhang G; Zhao Y; Yao H; Hu J; Tüksammel E; Cai H; Liang N; Xu X; Yang X; Schmidt S; Qiao X; Schlisio S; Strömblad S; Qian H; Jiang C; Treuter E; Bergo MO
Article: NATURE COMMUNICATIONS. 2023;14(1):4734

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles.

Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost JP; Görgens A; Zhao Y; Mamand DR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZ; El Andaloussi S
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2023;11(2):e005691

Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models.

Schoutrop E; Poiret T; El-Serafi I; Zhao Y; He R; Moter A; Henriksson J; Hassan M; Magalhaes I; Mattsson J
Article: PHYTOMEDICINE. 2023;110:154634

Celastrol targets the ChREBP-TXNIP axis to ameliorates type 2 diabetes mellitus.

Zhou D; Li X; Xiao X; Wang G; Chen B; Song Y; Liu X; He Q; Zhang H; Wu Q; Zhang L; Wu L; Shen Z; Hassan M; Zhao Y; Zhou W
Article: INTERNATIONAL JOURNAL OF NANOMEDICINE. 2023;18:1835-1847

Cellulose Nanofiber-Coated Perfluoropentane Droplets: Fabrication and Biocompatibility Study.

Loskutova K; Torras M; Zhao Y; Svagan AJ; Grishenkov D
Article: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY. 2023;19(1):28-35

Perfluorocarbon-Encapsulated Porphyrin-Lipid Nanoparticles as a Photoactive Pyroptosis Inducer for Cancer Therapy

Lin X; Jiang X; Xu Y; Liu R; Zhang N; Li R; Xiang H; Zhao C; Zhao Z; Zeng W; Qu S; Tan X; Cheng C; Chen X; Wang M; Liu Y; Liu L; Zhao Y; Dai Z; Hassan M; Sun D
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(7):e12248

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models.

Liang X; Niu Z; Galli V; Howe N; Zhao Y; Wiklander OPB; Zheng W; Wiklander RJ; Corso G; Davies C; Hean J; Kyriakopoulou E; Mamand DR; Amin R; Nordin JZ; Gupta D; Andaloussi SE
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2022;:1-8

Quantitative evaluation of liver function with gadoxetic acid enhanced MRI: Comparison among signal intensity-, T1-relaxometry-, and dynamic-hepatocyte-specific-contrast-enhanced MRI- derived parameters.

Wang Q; Kesen S; Liljeroth M; Nilsson H; Zhao Y; Sparrelid E; Brismar TB
Article: NPJ BREAST CANCER. 2022;8(1):2

Endoplasmic reticulum stress inhibits AR expression via the PERK/eIF2α/ATF4 pathway in luminal androgen receptor triple-negative breast cancer and prostate cancer.

Li X; Zhou D; Cai Y; Yu X; Zheng X; Chen B; Li W; Zeng H; Hassan M; Zhao Y; Zhou W
Article: JOURNAL OF PERSONALIZED MEDICINE. 2022;12(1):42

COL-3-Induced Molecular and Ultrastructural Alterations in K562 Cells.

Fares M; Oerther S; Hultenby K; Gubrianska D; Zhao Y; Abedi-Valugerdi M; Hassan M
Article: CANCER RESEARCH. 2021;81(11):3022-3035

Mesothelin-Specific CAR T Cells Target Ovarian Cancer.

Schoutrop E; El-Serafi I; Poiret T; Zhao Y; Gultekin O; He R; Moyano-Galceran L; Carlson JW; Lehti K; Hassan M; Magalhaes I; Mattsson J
Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2021;601:120588

Biodistribution of fluorescence-labelled EGF protein from slow release NanoZolid depots in mouse.

Grudén S; Brunmark C; Holmqvist B; Brenndörfer ED; Johansson M; Liu J; Zhao Y; Axén N; Hassan M
Article: BONE MARROW TRANSPLANTATION. 2021;56(4):807-817

Vitamin D levels and busulphan kinetics in patients undergoing hematopoietic stem cell transplantation, a multicenter study.

El-Serafi A; He R; Zheng W; Benkossou F; Oerther S; Zhao Y; Mellgren K; Gustafsson B; Heilmann C; Kanerva J; Lotfi K; Toporski J; Sundin M; Höglund M; Mattsson J; El-Serafi I; Hassan M
Article: ACS APPLIED MATERIALS & INTERFACES. 2020;12(48):53665-53681

Multimodal Imaging of Pancreatic Ductal Adenocarcinoma Using Multifunctional Nanoparticles as Contrast Agents.

Zhao Y; Ye F; Brismar TB; Li X; He R; Heuchel R; El-Sayed R; Feliu N; Zheng W; Oerther S; Dutta J; Parak WJ; Muhammed M; Hassan M
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging.

Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Görgens A; Nordin JZ; El Andaloussi S
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2020;143:105158

Pharmacokinetic profile of N-acetylcysteine amide and its main metabolite in mice using new analytical method.

He R; Zheng W; Ginman T; Ottosson H; Norgren S; Zhao Y; Hassan M
Article: SCIENTIFIC REPORTS. 2020;10(1):1274

A general covalent binding model between cytotoxic selenocompounds and albumin revealed by mass spectrometry and X-ray absorption spectroscopy.

Zheng W; He R; Boada R; Subirana MA; Ginman T; Ottosson H; Valiente M; Zhao Y; Hassan M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(19):E4734-4734

Extracellular Albumin Covalently Sequesters Selenocompounds and Determines Cytotoxicity.

Zheng W; Boada R; He R; Xiao T; Ye F; Simonelli L; Valiente M; Zhao Y; Hassan M
Article: APPLIED MATERIALS TODAY. 2019;15:267-279

Tracking stem cells and macrophages with gold and iron oxide nanoparticles - The choice of the best suited particles

Sun X; Gamal M; Nold P; Said A; Chakraborty I; Pelaz B; Schmied F; von Pueckler K; Figiel J; Zhao Y; Brendel C; Hassan M; Parak WJ; Feliu N
Article: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY. 2019;24(5):639-648

Pre-formulation investigations for establishing a protocol for treosulfan handling and activation.

El-Serafi I; Loy O; Zhao Y; Oerther S; Mattsson J
Article: BLOOD ADVANCES. 2018;2(5):534-548

Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm.

Xiao P; Dolinska M; Sandhow L; Kondo M; Johansson A-S; Bouderlique T; Zhao Y; Li X; Dimitriou M; Rassidakis GZ; Hellström-Lindberg E; Minato N; Walfridsson J; Scadden DT; Sigvardsson M; Qian H
Article: NANO TODAY. 2018;18:103-123

Advances in nanotechnology for cancer biomarkers

Ye F; Zhao Y; Ei-Sayed R; Muhammed M; Hassan M
Article: ANALYTICAL CHEMISTRY. 2017;89(14):7586-7592

Rapid and Robust Quantification of p-Xyleneselenocyanate in Plasma via Derivatization.

Zheng W; Benkessou F; Twelkmeyer B; Wang S; Ginman T; Ottosson H; Abedi-Valugerdi M; Subirana MA; Zhao Y; Hassan M
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2017;47:173-181

Differential effects of low-dose fludarabine or 5-fluorouracil on the tumor growth and myeloid derived immunosuppression status of tumor-bearing mice.

Abedi-Valugerdi M; Zheng W; Benkessou F; Zhao Y; Hassan M
Article: JOURNAL OF NANOBIOTECHNOLOGY. 2016;14(1):82

Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging.

Asem H; Zhao Y; Ye F; Barrefelt Å; Abedi-Valugerdi M; El-Sayed R; El-Serafi I; Abu-Salah KM; Hamm J; Muhammed M; Hassan M
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2016;40:41-49

Suppressive effects of low-dose 5-fluorouracil, busulfan or treosulfan on the expansion of circulatory neutrophils and myeloid derived immunosuppressor cells in tumor-bearing mice.

Abedi-Valugerdi M; Wolfsberger J; Pillai PR; Zheng W; Sadeghi B; Zhao Y; Hassan M
Article: SCIENTIFIC REPORTS. 2016;6:27455

Local Immune Stimulation by Intravesical Instillation of Baculovirus to Enable Bladder Cancer Therapy.

Ang WX; Zhao Y; Kwang T; Wu C; Chen C; Toh HC; Mahendran R; Esuvaranathan K; Wang S
Article: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY. 2016;13:48-57

Development and biodistribution of a theranostic aluminum phthalocyanine nanophotosensitizer.

Asem H; El-Fattah AA; Nafee N; Zhao Y; Khalil L; Muhammed M; Hassan M; Kandil S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015;464(3):737-742

Fluorescence labeled microbubbles for multimodal imaging.

Barrefelt Å; Zhao Y; Larsson MK; Egri G; Kuiper RV; Hamm J; Saghafian M; Caidahl K; Brismar TB; Aspelin P; Heuchel R; Muhammed M; Dähne L; Hassan M
Journal article: PANCREATOLOGY. 2014;14(3):s73-s74

Comparative analysis of orthotopically transplanted pancreatic cancer cells derived from 2D or 3D spheroid culture

Norberg J; Zhao Y; Nania S; Verbeke C; Löhr M; Heuchel R
Article: THERANOSTICS. 2014;4(6):604-613

Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound.

Gerling M; Zhao Y; Nania S; Norberg KJ; Verbeke CS; Englert B; Kuiper RV; Bergström A; Hassan M; Neesse A; Löhr JM; Heuchel RL
Journal article: PANCREATOLOGY. 2013;13(3):s19

Detection of hypoxic areas in a syngeneic, orthotopic model of pancreatic ductal adenocarcinoma in mouse by in vivo imaging using photoacoustics

Heuchel R; Gerling M; Zhao Y; Jose J; Norberg J; Toftgård R; Löhr M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;434(1):110-116

Quantum dot coating of baculoviral vectors enables visualization of transduced cells and tissues.

Zhao Y; Lo SL; Zheng Y; Lam DH; Wu C; Han MY; Wang S
Article: BIOMATERIALS. 2011;32(11):2969-2978

Multimodal tumor imaging by iron oxides and quantum dots formulated in poly (lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles.

Tan YF; Chandrasekharan P; Maity D; Yong CX; Chuang K-H; Zhao Y; Wang S; Ding J; Feng S-S
Article: HUMAN GENE THERAPY. 2010;21(6):683-694

Human NT2 neural precursor-derived tumor-infiltrating cells as delivery vehicles for treatment of glioblastoma.

Zhao Y; Wang S
Article: JOURNAL OF BIOSCIENCE AND BIOENGINEERING. 2010;109(1):1-8

The combined use of viral transcriptional and post-transcriptional regulatory elements to improve baculovirus-mediated transient gene expression in human embryonic stem cells.

Du J; Zeng J; Zhao Y; Boulaire J; Wang S
Article: MOLECULAR THERAPY. 2009;17(12):2058-2066

Combinatorial control of suicide gene expression by tissue-specific promoter and microRNA regulation for cancer therapy.

Wu C; Lin J; Hong M; Choudhury Y; Balani P; Leung D; Dang LH; Zhao Y; Zeng J; Wang S
Article: JOURNAL OF NEUROCHEMISTRY. 2009;109(5):1203-1214

Gene expression profiling to define host response to baculoviral transduction in the brain.

Boulaire J; Zhao Y; Wang S
Article: MOLECULAR THERAPY. 2009;17(6):1003-1011

High mobility group box2 promoter-controlled suicide gene expression enables targeted glioblastoma treatment.

Balani P; Boulaire J; Zhao Y; Zeng J; Lin J; Wang S
Article: CANCER RESEARCH. 2008;68(12):4614-4622

Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells.

Jurvansuu J; Zhao Y; Leung DSY; Boulaire J; Yu YH; Ahmed S; Wang S
Article: STEM CELLS. 2007;25(4):1055-1061

Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells.

Zeng J; Du J; Zhao Y; Palanisamy N; Wang S
Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2004;281(1-2):11-23

Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies.

Yu S; Zhao Y; Wu F; Zhang X; Lü W; Zhang H; Zhang Q
Article: BEIJING DA XUE XUE BAO. 2004;36(4):417-420

[Influence of seven absorption enhancers on nasal mucosa--assessment of toxicity].

Zhao Y; Zhang D-W; Zheng A-P; Yu S-Y; Wu F-L
Article: BEIJING DA XUE XUE BAO. 2004;36(3):300-304

[Preparation and properties of 5-fluorouracil-loaded chitosan microspheres for the intranasal administration].

Zheng A-P; Yu S-Y; Zhao Y; Wu F-L
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All other publications

Conference publication: BLOOD. 2022;140:4463-4464

The Role of N-Acetylcysteine Amide (NACA) As Prophylactic Treatment for Acute Graft-Versus-Host Disease

He R; Zheng W; Rozing K; Li X; Yin Y; El Andaloussi S; Norgren S; Zhao Y; Hassan M
Review: JOURNAL OF PERSONALIZED MEDICINE. 2022;12(11):1797

Cardiovascular Complications in Hematopoietic Stem Cell Transplanted Patients.

Zhao Y; He R; Oerther S; Zhou W; Vosough M; Hassan M
Review: EUROPEAN RADIOLOGY. 2022;32(3):1792-1803

Predictive value of gadoxetic acid-enhanced MRI for posthepatectomy liver failure: a systematic review.

Wang Q; Wang A; Sparrelid E; Zhang J; Zhao Y; Ma K; Brismar TB
Conference publication: BLOOD. 2021;138:3821

N-Acetylcysteine Amide Alleviates Cyclophosphamide-Induced Endothelial Damage

Hassan M; Ljungman P; He R; Norgren S; Zheng W; Zhao Y; Mansson-Broberg A; Wardell E; Slof T
Review: ACS NANO. 2021;15(3):3754-3807

X-ray-Based Techniques to Study the Nano-Bio Interface.

Sanchez-Cano C; Alvarez-Puebla RA; Abendroth JM; Beck T; Blick R; Cao Y; Caruso F; Chakraborty I; Chapman HN; Chen C; Cohen BE; Conceição ALC; Cormode DP; Cui D; Dawson KA; Falkenberg G; Fan C; Feliu N; Gao M; Gargioni E; Glüer C-C; Grüner F; Hassan M; Hu Y; Huang Y; Huber S; Huse N; Kang Y; Khademhosseini A; Keller TF; Körnig C; Kotov NA; Koziej D; Liang X-J; Liu B; Liu S; Liu Y; Liu Z; Liz-Marzán LM; Ma X; Machicote A; Maison W; Mancuso AP; Megahed S; Nickel B; Otto F; Palencia C; Pascarelli S; Pearson A; Peñate-Medina O; Qi B; Rädler J; Richardson JJ; Rosenhahn A; Rothkamm K; Rübhausen M; Sanyal MK; Schaak RE; Schlemmer H-P; Schmidt M; Schmutzler O; Schotten T; Schulz F; Sood AK; Spiers KM; Staufer T; Stemer DM; Stierle A; Sun X; Tsakanova G; Weiss PS; Weller H; Westermeier F; Xu M; Yan H; Zeng Y; Zhao Y; Zhao Y; Zhu D; Zhu Y; Parak WJ
Book chapter: COLLOIDS FOR NANOBIOTECHNOLOGY - SYNTHESIS, CHARACTERIZATION AND POTENTIAL APPLICATIONS: FRONTIERS OF NANOSCIENCE. 2020;p. 67-88

Chapter 4 Nanoparticles for imaging application

Zhao Y; Zheng W; Hassan M

Grants

Synthetic Selenium Compounds for Hematological Malignancies Treatment: Genomic Study in Preclinical Models

Swedish Research Council

1 January 2017 - 31 December 2018

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