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Substances with special rules, prohibition or permit requirements

Responsible for safe handling of hazardous chemcials is the employer (prefect, principal investigator, manager). In case of exposure at levels that may pose a risk to helth, the employer must establish a register of the persons who have been exposed, and the estimated exposure levels. This record shall be kept for 40 years.

Therefore, it is important to make accurate risk assessments and to develop procedures so that the handling of CMR substances is performed in such a way that exposure does not occur.

CMR-klassified chemicals

CMR classified chemical product are those marked with hazard statements and/or risk phrases

H350: May cause cancer
H340: May cause genetic defects
H360: May damage fertility or the unborn child

A CMR classified chemical product is only allowed to be handled if there is a documented investigating showing that it is not techically possible to replace the product with a less hazardous product. A form for this purpose is found under Documents.

If the investigation shows that it is not possible to replace the CMR-product it is required follow documented handling instructions and to conduct written risk assessments before work starts and here are some important parts to concider:

1. In which places and areas will the product be handled and what measures will be taken to ensure that only people who needed work are present in the area?

2. What safety measures will be taken to ensure that the exposure is minimal.

3. In what situations is it important with personal protective equipment?

4. Wow to handling and function of technical eqipment, processes and ventilation shoud be monitored to early detect abnormalities that can lead to increased risk.

Lack of routines and risk assessments or incident/accidents may cause hazardous exposure of these substances, which may cause illness, in long och short term.

Cytostatic drugs

Ethidium bromide

Liquid nitrogen


Peroxide forming chemicals


If ther is risk for hazardous exposure an exposure register must be established. The aim of the registry is to facilitate investigations of work related diseases and should therefore be stored in a safe place for 40 years.

Substances covered by the register requirement are:

Carcinogens - chemical products/substances classified according to CLP as H350 (may cancer).

Mutagens - chemical products/substances classified according to CLP as H340 (may cause genetic defects).

No reproductive toxic substances are covered by this statement.

The register shall contain:

  • The employee's name and social security number
  • Duties and period when the work was conducted
  • Substances
  • Measured or estimated levels of exposure

Karolinska Institutet are not able to establish a central register, it is up to each department to do so. Prefects are responsible for establishment and safe storage of the registers.

For more information read AFS 2014:43 (in Swedish only) and/or visit The Swedish Work Environment Authority (Arbetsmiljöverket).