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Three coronavirus projects coordinated by researchers at Karolinska Institutet have moved onto the grant negotiation phase in a bid for 9 million euros (95 million kronor) in EU funding. The projects aim to find a vaccine, immunotherapies and neutralizing antibodies against SARS-CoV-2 and are being coordinated by KI’s Matti Sällberg, Qiang Pan Hammarström and Benjamin Murrell.

Gene therapy can protect against ALS and SMA-related cell death

Researchers at Karolinska Institutet in Sweden and the University of Milan in Italy have identified a gene in human neurons that protects against the degeneration of motor neurons in the deadly diseases ALS and SMA. Gene therapy in animal models of these diseases was shown to protect against cell death and increase life expectancy. The study is published in the eminent journal Acta Neuropathologica.

Locomotor engine in the spinal cord revealed

Researchers at Karolinska Institutet in Sweden have revealed a new principle of organisation which explains how locomotion is coordinated in vertebrates akin to an engine with three gears. The results are published in the scientific journal Neuron.

New opportunity for cancer drug development

After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in the scientific journal Nature Communications, open for new strategies to treat different types of cancer.

Free tool simplifies cancer research

Researchers at Karolinska Institutet have developed a new method for identifying which proteins are affected by specific drugs. The tool and the results it has already generated have been made freely available online. The method is described in the scientific journal Nature Communications.